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trpC trpC ileS ileS ptsH ptsH tpiA tpiA mntH mntH hrcA hrcA grpE grpE dnaK dnaK dnaG dnaG pyrR pyrR galR galR dapA dapA dnaA dnaA rex rex glyA glyA gyrA gyrA ldh ldh pykF pykF pfk pfk ilvE ilvE pyrF pyrF eno eno adhE adhE pulA pulA ccpA ccpA fabM fabM codY codY comD comD psaR psaR groEL groEL groES groES rpoB rpoB rl17 rl17 rpoA rpoA adk adk rpsJ rpsJ ilvD ilvD guaB guaB ilvB ilvB ilvC ilvC ilvA ilvA rpsL rpsL rpsG rpsG fusA fusA pgk pgk glnR glnR copY copY cshB cshB trpE trpE trpD trpD
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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trpCBest Blastp Hit: sp|Q01999|TRPC_LACLA INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (IGPS) >gi|421422|pir||S35127 indole-3-glycerol-phosphate synthase (EC 4.1.1.48) - Lactococcus lactis subsp. lactis >gi|149519|gb|AAA25226.1| (M87483) indoleglycerol phosphate synthase [Lactococcus lactis]; Belongs to the TrpC family. (255 aa)
ileSisoleucine-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (930 aa)
ptsHPhosphoenolpyruvate:sugar phosphotransferase system HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (87 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
mntHPutative manganese transporter; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. (446 aa)
hrcATranscriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (344 aa)
grpEHeat shock protein GrpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Seve [...] (179 aa)
dnaKHeat shock protein, DnaK (HSP-70); Acts as a chaperone; Belongs to the heat shock protein 70 family. (612 aa)
dnaGPutative DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (592 aa)
pyrRPutative pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (176 aa)
galRBest Blastp Hit: pir||JC5310 galactose repressor - Streptococcus mutans. (334 aa)
dapAPutative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
dnaAChromosomal replication initiator protein, DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (452 aa)
rexConserved hypothetical protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (213 aa)
glyAPutative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
gyrADNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (825 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
pykFPyruvate kinase; Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus]. (500 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
ilvEBest Blastp Hit: gb|AAF34406.1|AF164204_1 (AF164204) branched-chain amino acid aminotransferase [Lactococcus lactis subsp. cremoris] >gi|7620382|gb|AAF64593.1|AF169649_1 (AF169649) branched-chain aminotransferase IlvE [Lactococcus lactis]. (341 aa)
pyrFPutative orotidine-5'-decarboxylase PyrF; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (230 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family. (432 aa)
adhEBest Blastp Hit: emb|CAA04467.1| (AJ001008) Alcohol-acetaldehyde dehydrogenase [Lactococcus lactis]; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (889 aa)
pulAPutative pullulanase; Best Blastp Hit: prf||1808262A thermostable pullulanase [Bacillus stearothermophilus]; Belongs to the glycosyl hydrolase 13 family. (743 aa)
ccpACatabolite control protein A, CcpA; Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. (333 aa)
fabMPutative enoyl-CoA hydratase; Catalyzes the isomerization of trans-2-decenoyl-ACP to cis-3- decenoyl-ACP (By similarity). Required for survival at low pH. (263 aa)
codYPutative transcriptional regulator; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (261 aa)
comDPutative histidine kinase of the competence regulon, ComD; Best Blastp Hit: emb|CAC10175.1| (AJ278302) histidine kinase [Streptococcus pneumoniae]. (441 aa)
psaRPutative transcriptional regulator; Best Blastp Hit: dbj|BAB04438.1| (AP001509) transcriptional regulator (TetR/AcrR family) [Bacillus halodurans]. (191 aa)
groELPutative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa)
groESPutative co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
rpoBDNA-dependent RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1187 aa)
rl17Best Blastp Hit: sp|P20277|RL17_BACSU 50S RIBOSOMAL PROTEIN L17 (BL15) (BL21) >gi|80370|pir||F32307 ribosomal protein L17 - Bacillus subtilis >gi|142464|gb|AAA22218.1| (M26414) ribosomal protein L17 [Bacillus subtilis] >gi|1044992|gb|AAB06827.1| (L47971) ribosomal protein L17 [Bacillus subtilis] >gi|2632411|emb|CAB11920.1| (Z99104) ribosomal protein L17 (BL15) [Bacillus subtilis]. (128 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
adkPutative adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (36 aa)
ilvDBest Blastp Hit: sp|P74689|ILVD_SYNY3 DIHYDROXY-ACID DEHYDRATASE (DAD) >gi|7436855|pir||S76895 hypothetical protein - Synechocystis sp. (strain PCC 6803) >gi|1653897|dbj|BAA18807.1| (D90917) dihydroxyacid dehydratase [Synechocystis sp.]; Belongs to the IlvD/Edd family. (571 aa)
guaBInosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
ilvBBest Blastp Hit: sp|Q02137|ILVB_LACLA ACETOLACTATE SYNTHASE LARGE SUBUNIT (AHAS) (ACETOHYDROXY-ACID SYNTHASE LARGE SUBUNIT) (ALS) >gi|486730|pir||S35138 acetolactate synthase (EC 4.1.3.18) - Lactococcus lactis subsp. lactis >gi|2565157|gb|AAB81919.1| (U92974) IlvB [Lactococcus lactis]. (567 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (137 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
fusATranslation elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G [...] (693 aa)
pgkPhosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa)
glnRBest Blastp Hit: sp|P19083|GLNR_BACCE REGULATORY PROTEIN GLNR >gi|80075|pir||JU0076 hypothetical 15K protein (glnA 5' region) - Bacillus cereus >gi|216272|dbj|BAA00402.1| (D00513) ORF129 [Bacillus cereus]. (123 aa)
copYNegative transcriptional regulator, CopY; Best Blastp Hit: gb|AAG10085.1|AF296446_1 (AF296446) CopY [Streptococcus mutans]. (147 aa)
cshBPutative ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa)
trpEPutative anthranilate synthase, alpha subunit; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and h [...] (453 aa)
trpDPutative phosphoribosyl anthranilate transferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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