STRINGSTRING
pepV pepV pepN pepN amyA amyA clpP clpP pepP pepP groEL groEL groES groES ctsR ctsR pepO pepO pepT pepT capP capP hrcA hrcA grpE grpE dnaK dnaK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pepVPutative dipeptidase; Best Blastp Hit: gb|AAC45369.1| (U78036) dipeptidase [Lactococcus lactis]. (470 aa)
pepNAminopeptidase N, PepN; Best Blastp Hit: emb|CAB50785.1| (AJ007700) aminopeptidase N [Streptococcus thermophilus]. (849 aa)
amyAIntracellular alpha-amylase; Best Blastp Hit: gb|AAC35010.1| (AF055987) intracellular a-amylase [Streptococcus mutans]. (486 aa)
clpPPutative ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (196 aa)
pepPPutative aminopeptidase P; Best Blastp Hit: emb|CAA70068.1| (Y08842) aminopeptidase P [Lactococcus lactis]; Belongs to the peptidase M24B family. (354 aa)
groELPutative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa)
groESPutative co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
ctsRPutative transcriptional regulator CtsR; Best Blastp Hit: emb|CAB91548.1| (AJ249133) CtsR protein [Lactococcus lactis]; Belongs to the CtsR family. (154 aa)
pepOPutative peptidase; Best Blastp Hit: emb|CAC14579.1| (AJ249396) oligopeptidase [Streptococcus thermophilus]. (631 aa)
pepTPutative tripeptidase (peptidase T); Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (406 aa)
capPPutative phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (907 aa)
hrcATranscriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (344 aa)
grpEHeat shock protein GrpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Seve [...] (179 aa)
dnaKHeat shock protein, DnaK (HSP-70); Acts as a chaperone; Belongs to the heat shock protein 70 family. (612 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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