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pfl pfl fbaA fbaA bglA bglA galR galR hprK hprK tpiA tpiA pgm pgm ascB ascB ldh ldh pfk pfk eno eno SMU_1335c SMU_1335c ccpA ccpA bgl bgl fabZ fabZ fabF fabF fabG fabG fabH fabH scrK scrK pgi pgi pgk pgk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pflPyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans]. (775 aa)
fbaABest Blastp Hit: dbj|BAB16889.1| (AB050113) class-II aldolase [Streptococcus bovis]. (293 aa)
bglAPutative beta-glucosidase; Best Blastp Hit: gb|AAF89979.1|AF206272_5 (AF206272) beta-glucosidase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 1 family. (479 aa)
galRBest Blastp Hit: pir||JC5310 galactose repressor - Streptococcus mutans. (334 aa)
hprKHPr(serine) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable [...] (311 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
pgmPutative phosphoglucomutase; Best Blastp Hit: emb|CAB96418.1| (AJ243290) phosphoglucomutase [Streptococcus thermophilus]. (571 aa)
ascB6-phospho-beta-glucosidase; Best Blastp Hit: gb|AAA69226.1| (U29579) 6-phospho-beta-glucosidase [Escherichia coli]; Belongs to the glycosyl hydrolase 1 family. (478 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family. (432 aa)
SMU_1335cPutative enoyl-(acyl-carrier-protein) reductase; Best Blastp Hit: gb|AAF98273.1|AF197933_3 (AF197933) trans-2-enoyl-ACP reductase II [Streptococcus pneumoniae]. (327 aa)
ccpACatabolite control protein A, CcpA; Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. (333 aa)
bglPutative phospho-beta-glucosidase; Best Blastp Hit: pir||JE0395 phospho-beta-galactosidase I - Lactobacillus gasseri >gi|2114112|dbj|BAA20086.1| (AB003927) phospho-beta-galactosidase 1 [Lactobacillus gasseri]; Belongs to the glycosyl hydrolase 1 family. (477 aa)
fabZPutative 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
fabFPutative 3-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
fabGPutative 3-oxoacyl-acyl-carrier-protein reductase / 3-ketoacyl-acyl carrier protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
fabHPutative 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (325 aa)
scrKPutative fructokinase; Best Blastp Hit: sp|Q07211|SCRK_STRMU FRUCTOKINASE >gi|287459|dbj|BAA02467.1| (D13175) fructokinase [Streptococcus mutans]. (293 aa)
pgiGlucose-6-phosphate isomerase; Best Blastp Hit: gb|AAD33517.1|AF132127_2 (AF132127) glucose-6-phosphate isomerase [Streptococcus mutans]. (449 aa)
pgkPhosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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