STRINGSTRING
rgpF rgpF msmR msmR msmE msmE gtfA gtfA msmK msmK dexB dexB gtfD gtfD tpx tpx clpX clpX wapA wapA sfp sfp SMU_1287 SMU_1287 gtfC gtfC gtfB gtfB rgpA rgpA rgpE rgpE SMU_833 SMU_833 ahpC ahpC SMU_739c SMU_739c trxB trxB rgpG rgpG SMU_2165 SMU_2165 htrA htrA mreC mreC ssb2 ssb2 comE comE trxA trxA clpP clpP cah cah gbpC gbpC mleS mleS SMU_1349 SMU_1349
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rgpFRgpFc protein; Best Blastp Hit: pir||T00091 rgpFc protein - Streptococcus mutans >gi|3399709|dbj|BAA32094.1| (AB010970) rgpFc [Streptococcus mutans]. (583 aa)
msmRPutative MSM operon regulatory protein; Regulatory protein for the msm operon for multiple sugar metabolism. Activates the transcription of the msmEFGK, aga, dexB and gftA genes. (278 aa)
msmEMultiple sugar-binding ABC transporter, sugar-binding protein precursor MsmE; Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose. (420 aa)
gtfASucrose phosphorylase, GtfA; Intracellular catabolism of sucrose. Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris. (481 aa)
msmKMultiple sugar-binding ABC transporter, ATP-binding protein, MsmK; Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (377 aa)
dexBDextran glucosidase DexB; The physiological substrates may be short isomaltosaccharides. (536 aa)
gtfDglucosyltransferase-S; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1462 aa)
tpxThiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (161 aa)
clpXATP-dependent protease Clp, ATPase subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (410 aa)
wapABest Blastp Hit: sp|P11000|WAPA_STRMU WALL-ASSOCIATED PROTEIN PRECURSOR >gi|98001|pir||S06992 wall-associated protein A precursor - Streptococcus mutans >gi|153858|gb|AAA88608.1| (M37842) wall-associated protein [Streptococcus mutans]. (453 aa)
sfpBest Blastp Hit: gb|AAG24257.1| (AY009114) phosphopantetheinyl transferase [Bacillus subtilis]; Belongs to the P-Pant transferase superfamily. (230 aa)
SMU_1287Putative transcriptional regulator; Best Blastp Hit: dbj|BAB05213.1| (AP001512) transcriptional regulator [Bacillus halodurans]. (116 aa)
gtfCglucosyltransferase-SI; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1455 aa)
gtfBglucosyltransferase-I; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1476 aa)
rgpAPutative RgpAc; Best Blastp Hit: pir||T00086 rgpAc protein - Streptococcus mutans >gi|3399704|dbj|BAA32089.1| (AB010970) rgpAc [Streptococcus mutans]. (362 aa)
rgpEBest Blastp Hit: pir||T00090 glycosyltransferase rgpEc - Streptococcus mutans >gi|3399708|dbj|BAA32093.1| (AB010970) glycosyltransferase [Streptococcus mutans]. (465 aa)
SMU_833Putative glycosyltransferase; Best Blastp Hit: sp|Q45539|CSBB_BACSU CSBB PROTEIN >gi|2126920|pir||JC5173 stress response protein csbB - Bacillus subtilis >gi|1387979|gb|AAB38429.1| (L77099) 44% identity over 302 residues with hypothetical protein from Synechocystis sp, accession D64006_CD; expression induced by environmental stress; some similarity to glycosyl transferases; two potential membrane-spanning helices [Bacillus subtil> >gi|2633183|emb|CAB12688.1| (Z99108) stress response protein [Bacillus subtilis] >gi|2804544|dbj|BAA24480.1| (D85082) YfhN [Bacillus subtilis]. (308 aa)
ahpCAlkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (186 aa)
SMU_739cHypothetical protein; Best Blastp Hit: gi|6319355 Ybl113cp [Saccharomyces cerevisiae] >gi|2131309|pir||S70305 hypothetical protein YBL113c - yeast (Saccharomyces cerevisiae). (518 aa)
trxBBest Blastp Hit: dbj|BAB07290.1| (AP001519) thioredoxin reductase (NADPH) [Bacillus halodurans]. (304 aa)
rgpGPutative glycosyl transferase N-acetylglucosaminyltransferase), RgpG; Best Blastp Hit: dbj|BAA82114.1| (AB022909) RgpG [Streptococcus mutans]. (386 aa)
SMU_2165Putative SpoJ; Belongs to the ParB family. (257 aa)
htrASerine protease HtrA; Best Blastp Hit: gb|AAC45334.1| (AF000658) putative serine protease [Streptococcus pneumoniae]. (402 aa)
mreCPutative cell shape-determining protein MreC; Involved in formation and maintenance of cell shape. (269 aa)
ssb2Putative single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (131 aa)
comEPutative response regulator of the competence regulon, ComE; Best Blastp Hit: gb|AAB41200.1| (U75483) sakacin A production response regulator [Streptococcus mutans]. (250 aa)
trxAPutative thioredoxin; Best Blastp Hit: emb|CAB40815.2| (AJ133006) thioredoxin [Listeria monocytogenes]; Belongs to the thioredoxin family. (104 aa)
clpPPutative ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (196 aa)
cahBest Blastp Hit: dbj|BAB04079.1| (AP001508) carbonic anhydrase precursor [Bacillus halodurans]. (256 aa)
gbpCGlucan-binding protein C, GbpC; Best Blastp Hit: dbj|BAA12713.1| (D85031) glucan-binding protein C [Streptococcus mutans]. (583 aa)
mleSMalolactic enzyme; Best Blastp Hit: pir||S43057 malolactic enzyme - Lactococcus lactis >gi|2130997|emb|CAA53589.1| (X75982) malolactic enzyme [Lactococcus lactis]. (540 aa)
SMU_1349Hypothetical protein; Best Blastp Hit: pir||C70487 transcription regulator TetR/AcrR family - Aquifex aeolicus >gi|2984362|gb|AAC07881.1| (AE000776) transcriptional regulator (TetR/AcrR family) [Aquifex aeolicus]. (191 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.