STRINGSTRING
prs prs scrB scrB manA manA fabH fabH fabD fabD fabG fabG fabF fabF fabZ fabZ malX malX adhE adhE SMU_140 SMU_140 pckA pckA SMU_134 SMU_134 pfkB pfkB fbaA fbaA tpx tpx bglA bglA eno eno pyrDB pyrDB dnaE dnaE pfk pfk adh adh mtlA1 mtlA1 mtlD mtlD spxA spxA ldh ldh radC radC krpS krpS cilG cilG oadB oadB citC citC gshR gshR dnaK dnaK fruB fruB tpiA tpiA pyrD pyrD cysK cysK pfl2 pfl2 luxS luxS pfl pfl glpF glpF pgk pgk gapC gapC radA radA SMU_308 SMU_308 recF recF SMU_2084c SMU_2084c treR treR ctsR ctsR ackA ackA groEL groEL
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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prsPhosphoribosyl pyrophosphate synthetase (PRPP synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa)
scrBBest Blastp Hit: sp|P13522|SCRB_STRMU SUCROSE-6-PHOSPHATE## HYDROLASE (SUCRASE) (INVERTASE) >gi|97999|pir||A43501 sucrose-6-phosphate hydrolase - Streptococcus mutans >gi|47259|emb|CAA35872.1| (X51507) sucrose-6-phosphate hydrolase [Streptococcus mutans] >gi|153804|gb|AAA26972.1| (M36849) sucrose-6-phosphate hydrolase [Streptococcus mutans]. (479 aa)
manABest Blastp Hit: sp|Q59935|MANA_STRMU MANNOSE-6-PHOSPHATE ISOMERASE (PHOSPHOMANNOSE ISOMERASE) (PMI) (PHOSPHOHEXOMUTASE) >gi|451216|dbj|BAA04021.1| (D16594) Mannosephosphate Isomerase [Streptococcus mutans]. (316 aa)
fabHPutative 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (325 aa)
fabDBest Blastp Hit: gb|AAF98274.1|AF197933_4 (AF197933) malonyl-CoA:ACP transacylase; MCAT [Streptococcus pneumoniae]. (306 aa)
fabGPutative 3-oxoacyl-acyl-carrier-protein reductase / 3-ketoacyl-acyl carrier protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
fabFPutative 3-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
fabZPutative 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
malXPutative maltose/maltodextrin ABC transporter, sugar-binding protein MalX; Best Blastp Hit: sp|P29850|MALX_STRPN MALTOSE/MALTODEXTRIN-BINDING PROTEIN PRECURSOR >gi|479206|pir||S32569 malX protein - Streptococcus pneumoniae >gi|153723|gb|AAA26925.1| (L08611) MalX [Streptococcus pneumoniae]. (415 aa)
adhEBest Blastp Hit: emb|CAA04467.1| (AJ001008) Alcohol-acetaldehyde dehydrogenase [Lactococcus lactis]; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (889 aa)
SMU_140Putative glutathione reductase; Best Blastp Hit: emb|CAA73495.1| (Y13052) ORF454 [Staphylococcus sciuri]. (431 aa)
pckABest Blastp Hit: pir||D72755 hypothetical protein APE0033 - Aeropyrum pernix (strain K1) >gi|5103421|dbj|BAA78942.1| (AP000058) 493aa long hypothetical protein [Aeropyrum pernix]. (546 aa)
SMU_134Putative transcriptional regulator (TetR/AcrR family); Best Blastp Hit: sp|P40950|YUXN_BACSU HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN MRGA-CITG INTERGENIC REGION >gi|7451417|pir||F70025 conserved hypothetical protein yuxN - Bacillus subtilis >gi|2635800|emb|CAB15293.1| (Z99120) similar to hypothetical proteins from B. subtilis [Bacillus subtilis] >gi|2832826|emb|CAA11750.1| (AJ223978) YuxN protein [Bacillus subtilis]. (217 aa)
pfkBPutative fructose-1-phosphate kinase; Best Blastp Hit: sp|O31714|K1PF_BACSU 1-PHOSPHOFRUCTOKINASE (FRUCTOSE 1-PHOSPHATE KINASE) >gi|7434216|pir||A69627 fructose 1-phosphate kinase fruB - Bacillus subtilis >gi|2633810|emb|CAB13312.1| (Z99111) fructose-1-phosphate kinase [Bacillus subtilis] >gi|3282124|gb|AAC24914.1| (AF012285) fructose-1-phosphate kinase [Bacillus subtilis]; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (303 aa)
fbaABest Blastp Hit: dbj|BAB16889.1| (AB050113) class-II aldolase [Streptococcus bovis]. (293 aa)
tpxThiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (161 aa)
bglAPutative beta-glucosidase; Best Blastp Hit: gb|AAF89979.1|AF206272_5 (AF206272) beta-glucosidase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 1 family. (479 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family. (432 aa)
pyrDBPutative dihydroorotate dehydrogenase B; Catalyzes the conversion of dihydroorotate to orotate. (309 aa)
dnaEDNA polymerase III, alpha chain; Best Blastp Hit: gb|AAF98350.1| (AF280766) DNA polymerase III alpha subunit [Streptococcus pyogenes]. (1034 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
adhBest Blastp Hit: gb|AAG07017.1|AE004783_2 (AE004783) alcohol dehydrogenase class III [Pseudomonas aeruginosa]; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
mtlA1PTS system, mannitol-specific enzyme IIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (569 aa)
mtlDBest Blastp Hit: sp|Q02418|MTLD_STRMU MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE >gi|282315|pir||C44798 mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) mtlD - Streptococcus mutans >gi|153746|gb|AAA26942.1| (AF210133) mannitol-phosphate dehydrogenase [Streptococcus mutans]. (382 aa)
spxAPutative arsenate reductase; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (137 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
radCBest Blastp Hit: sp|Q02170|RADC_BACSU DNA REPAIR PROTEIN RADC HOMOLOG (ORFB) >gi|322193|pir||B45239 DNA repair protein homolog ysxA - Bacillus subtilis >gi|142854|gb|AAA22396.1| (M96343) homologous to E. coli radC gene product and to unidentified protein from Staphylococcus aureus [Bacillus subtilis] >gi|143162|gb|AAA22583.1| (L08793) putative [Bacillus## subtilis] >gi|2635269|emb|CAB14764.1| (Z99118) similar to DNA repair protein [Bacillus subtilis]; Belongs to the UPF0758 family. (209 aa)
krpSPutative phosphoribosylpyrophosphate synthetase, PRPP synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
cilGPutative citrate lyase, gamma-subunit; Covalent carrier of the coenzyme of citrate lyase. (102 aa)
oadBPutative oxaloacetate decarboxylase, sodium ion pump subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (373 aa)
citCPutative citrate lyase ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (349 aa)
gshRGlutathione reductase; Best Blastp Hit: dbj|BAA76640.1| (AB019579) glutathione reductase (GR) [Streptococcus mutans]. (450 aa)
dnaKHeat shock protein, DnaK (HSP-70); Acts as a chaperone; Belongs to the heat shock protein 70 family. (612 aa)
fruBFructan hydrolase; Best Blastp Hit: gb|AAD28639.1| (U78296) FruB [Streptococcus mutans]. (519 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
pyrDPutative dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (311 aa)
cysKPutative cysteine synthetase A; Best Blastp Hit: dbj|BAA88310.1| (AB028865) O-acetylserine lyase [Streptococcus suis]; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)
pfl2Best Blastp Hit: sp|P75793|PFLF_ECOLI PUTATIVE FORMATE ACETYLTRANSFERASE 3 (PYRUVATE FORMATE-LYASE 3) >gi|7427871|pir||G64819 probable formate C-acetyltransferase (EC 2.3.1.54) - Escherichia coli >gi|1787044|gb|AAC73910.1| (AE000184) putative formate acetyltransferase [Escherichia coli] >gi|4062397|dbj|BAA35511.1| (D90720) Formate acetyltransferase 2 (EC 2.3.1.54) (pyruvate formate-lyase 2). [Escherichia coli]. (818 aa)
luxSPutative autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (160 aa)
pflPyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans]. (775 aa)
glpFPutative glycerol uptake facilitator protein; Best Blastp Hit: sp|P22094|YDP1_LACLC HYPOTHETICAL 30.9 KDA PROTEIN IN PEPX 5'REGION (ORF1) >gi|280238|pir||B43747 hypothetical protein (pepXP 5' region) - Lactococcus lactis subsp. cremoris >gi|280244|pir||B43748 hypothetical protein (pepX 5' region) - Lactococcus lactis subsp. lactis >gi|149527|gb|AAA25231.1| (M58315) putative [Lactococcus lactis] >gi|455286|gb|AAA25206.1| (M35865) ORF1 (put.); putative [Lactococcus lactis]; Belongs to the MIP/aquaporin (TC 1.A.8) family. (289 aa)
pgkPhosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa)
gapCExtracellular glyceraldehyde-3-phosphate dehydrogenase; Best Blastp Hit: sp|P50467|G3P_STRPY GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (GAPDH) (PLASMINOGEN-BINDING PROTEIN) (PLASMIN RECEPTOR) >gi|285385|pir||A42963 glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) - Streptococcus sp >gi|153763|gb|AAA26953.1| (M95569) plasmin receptor [Streptococcus pyogenes]. (337 aa)
radAPutative DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (466 aa)
SMU_308Best Blastp Hit: pir||T51721 sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140) [imported] - Streptococcus mutans >gi|4928282|gb|AAD33518.1|AF132127_3 (AF132127) sorbitol-6-phosphate dehydrogenase [Streptococcus mutans]; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
recFPutative RecF protein, ATPase involved in DNA repair; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (363 aa)
SMU_2084cConserved hypothetical protein; Best Blastp Hit: gb|AAF21893.1|AF103794_1 (AF103794) unknown [Listeria monocytogenes]; Belongs to the ArsC family. (132 aa)
treRPutative transcriptional regulator; Best Blastp Hit: dbj|BAB04592.1| (AP001510) transcriptional repressor of the trehalose operon [Bacillus halodurans]. (237 aa)
ctsRPutative transcriptional regulator CtsR; Best Blastp Hit: emb|CAB91548.1| (AJ249133) CtsR protein [Lactococcus lactis]; Belongs to the CtsR family. (154 aa)
ackAPutative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
groELPutative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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