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hisG hisG SMU_103 SMU_103 ldh ldh pykF pykF pfk pfk rpiA rpiA eno eno hisI hisI hisA hisA hisB hisB hisD hisD hisZ hisZ hisC hisC malQ malQ amyA amyA ccpA ccpA serA serA SMU_1725 SMU_1725 fabZ fabZ fabF fabF fabG fabG fabD fabD manA manA scrK scrK scrA scrA scrB scrB ackA ackA ptsG ptsG prs prs tkt tkt pgi pgi pgk pgk pfl pfl citB citB citZ citZ gapN gapN tpiA tpiA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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textmining
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hisGPutative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa)
SMU_103Putative PTS system, IIA component; Best Blastp Hit: gb|AAD46485.1|AF130465_1 (AF130465) mannose-specific phosphotransferase system component IIAB [Streptococcus salivarius]. (138 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
pykFPyruvate kinase; Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus]. (500 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
rpiAPutative ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family. (432 aa)
hisIPutative phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (109 aa)
hisABest Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. (239 aa)
hisBBest Blastp Hit: dbj|BAB07300.1| (AP001519) imidazoleglycerol-phosphate dehydratase [Bacillus halodurans]. (194 aa)
hisDPutative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
hisZPutative histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (320 aa)
hisCBest Blastp Hit: sp|Q02135|HIS8_LACLA HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (IMIDAZOLE ACETOL-PHOSPHATE TRANSAMINASE) >gi|2565139|gb|AAB81901.1| (U92974) HisC [Lactococcus lactis]; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (349 aa)
malQBest Blastp Hit: sp|P29851|MALQ_STRPN 4-ALPHA-GLUCANOTRANSFERASE (AMYLOMALTASE) (DISPROPORTIONATING ENZYME) (D-ENZYME) >gi|153704|gb|AAA26923.1| (J01796) amylomaltase [Streptococcus pneumoniae]. (509 aa)
amyAIntracellular alpha-amylase; Best Blastp Hit: gb|AAC35010.1| (AF055987) intracellular a-amylase [Streptococcus mutans]. (486 aa)
ccpACatabolite control protein A, CcpA; Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. (333 aa)
serABest Blastp Hit: sp|Q58424|SERA_METJA D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|2129189|pir||A64427 phosphoglycerate dehydrogenase (EC 1.1.1.95) - Methanococcus jannaschii >gi|1591676|gb|AAB99020.1| (U67544) phosphoglycerate dehydrogenase (serA) [Methanococcus jannaschii]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (393 aa)
SMU_1725Putative acylphosphatase; Best Blastp Hit: pir||G72240 hypothetical protein TM1564 - Thermotoga maritima (strain MSB8) >gi|4982131|gb|AAD36630.1|AE001801_17 (AE001801) acylphosphatase, putative [Thermotoga maritima]. (92 aa)
fabZPutative 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
fabFPutative 3-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
fabGPutative 3-oxoacyl-acyl-carrier-protein reductase / 3-ketoacyl-acyl carrier protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
fabDBest Blastp Hit: gb|AAF98274.1|AF197933_4 (AF197933) malonyl-CoA:ACP transacylase; MCAT [Streptococcus pneumoniae]. (306 aa)
manABest Blastp Hit: sp|Q59935|MANA_STRMU MANNOSE-6-PHOSPHATE ISOMERASE (PHOSPHOMANNOSE ISOMERASE) (PMI) (PHOSPHOHEXOMUTASE) >gi|451216|dbj|BAA04021.1| (D16594) Mannosephosphate Isomerase [Streptococcus mutans]. (316 aa)
scrKPutative fructokinase; Best Blastp Hit: sp|Q07211|SCRK_STRMU FRUCTOKINASE >gi|287459|dbj|BAA02467.1| (D13175) fructokinase [Streptococcus mutans]. (293 aa)
scrAPutative PTS system, sucrose-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in sucrose transport. (664 aa)
scrBBest Blastp Hit: sp|P13522|SCRB_STRMU SUCROSE-6-PHOSPHATE## HYDROLASE (SUCRASE) (INVERTASE) >gi|97999|pir||A43501 sucrose-6-phosphate hydrolase - Streptococcus mutans >gi|47259|emb|CAA35872.1| (X51507) sucrose-6-phosphate hydrolase [Streptococcus mutans] >gi|153804|gb|AAA26972.1| (M36849) sucrose-6-phosphate hydrolase [Streptococcus mutans]. (479 aa)
ackAPutative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
ptsGPutative PTS system, glucose-specific IIABC component; Best Blastp Hit: gb|AAD00281.1| (U78600) putative ptsG## protein [Streptococcus mutans]. (729 aa)
prsPhosphoribosyl pyrophosphate synthetase (PRPP synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa)
pgiGlucose-6-phosphate isomerase; Best Blastp Hit: gb|AAD33517.1|AF132127_2 (AF132127) glucose-6-phosphate isomerase [Streptococcus mutans]. (449 aa)
pgkPhosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa)
pflPyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans]. (775 aa)
citBAconitate hydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. (888 aa)
citZCitrate synthase; Best Blastp Hit: sp|Q59939|CISZ_STRMU CITRATE SYNTHASE >gi|1421813|gb|AAC44825.1| (U62799) citrate synthase [Streptococcus mutans]. (372 aa)
gapNBest Blastp Hit: sp|Q59931|GAPN_STRMU NADP-DEPENDENT GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (NON-PHOSPHORYLATING GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE) (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE [NADP+]) (TRIOSEPHOSPHATE DEHYDROGENASE) >gi|2117515|pir||A57151 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (EC 1.2.1.9) - Streptococcus mutans >gi|5822059|pdb|1EUH|A Chain A, Apo Form Of A Nadp Dependent Aldehyde Dehydrogenase From Streptococcus Mutans >gi|5822060|pdb|1EUH|B Chain B, Apo Form Of A Nadp Dependent Aldehyde Dehydrogenase From Streptococcus Mutans >gi|5822061|pdb|1EUH|C [...] (475 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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