STRINGSTRING
ftsA ftsA dnaA dnaA ldh ldh phoU phoU pykF pykF pfk pfk plsY plsY punA punA SMU_1388 SMU_1388 pdhB pdhB pdhA pdhA pdhD pdhD pnpA pnpA vacB vacB cdsA cdsA secA secA nusB nusB nusG nusG ackA ackA secY secY ptsG ptsG plsX plsX gltX gltX pgk pgk rny rny SMU_494 SMU_494 ftsZ ftsZ ptsH ptsH ptsI ptsI pyrG pyrG
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (453 aa)
dnaAChromosomal replication initiator protein, DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (452 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
phoUPutative phosphate transport system regulatory protein; Plays a role in the regulation of phosphate uptake. (217 aa)
pykFPyruvate kinase; Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus]. (500 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
plsYConserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (212 aa)
punAPutative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (269 aa)
SMU_1388Best Blastp Hit: pir||C69813 RNA helicase homolog yfmL - Bacillus subtilis >gi|2443255|dbj|BAA22326.1| (D86417) YfmL [Bacillus subtilis] >gi|2633067|emb|CAB12572.1| (Z99108) similar to RNA helicase [Bacillus subtilis]. (360 aa)
pdhBBest Blastp Hit: dbj|BAB05542.1| (AP001513) acetoin dehydrogenase E1 component (TPP-dependent beta subunit) [Bacillus halodurans]. (343 aa)
pdhAPutative pyruvate dehydrogenase, TPP-dependent E1 component alpha-subunit; Best Blastp Hit: pir||D69581 acetoin dehydrogenase E1 component (TPP-dependent alpha subuni) acoA - Bacillus subtilis >gi|2633130|emb|CAB12635.1| (Z99108) acetoin dehydrogenase E1 component (TPP-dependent alpha subunit) [Bacillus subtilis] >gi|2780395|dbj|BAA24296.1| (D78509) YfjK [Bacillus subtilis] >gi|2957146|gb|AAC05582.1| (AF006075) TPP-dependent acetoin dehydrogenase, E1 alpha-subunit [Bacillus subtilis]. (357 aa)
pdhDBest Blastp Hit: dbj|BAB04498.1| (AP001509) dihydrolipoamide dehydrogenase [Bacillus halodurans]. (445 aa)
pnpAPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (730 aa)
vacBPutative exoribonuclease R (RNAase R); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (778 aa)
cdsABest Blastp Hit: dbj|BAB06141.1| (AP001515) phosphatidate cytidylyltransferase [Bacillus halodurans]; Belongs to the CDS family. (264 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (839 aa)
nusBPutative transcription termination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (142 aa)
nusGPutative transcription antitermination factor; Participates in transcription elongation, termination and antitermination. (178 aa)
ackAPutative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
secYPutative preprotein translocase SecY protein; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (434 aa)
ptsGPutative PTS system, glucose-specific IIABC component; Best Blastp Hit: gb|AAD00281.1| (U78600) putative ptsG## protein [Streptococcus mutans]. (729 aa)
plsXPutative fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (332 aa)
gltXPutative glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa)
pgkPhosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa)
rnyConserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (535 aa)
SMU_494Putative transaldolase; Best Blastp Hit: emb|CAA05516.1| (AJ002527) OrfX [Clostridium beijerinckii]. (222 aa)
ftsZPutative cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (434 aa)
ptsHPhosphoenolpyruvate:sugar phosphotransferase system HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (87 aa)
ptsIPhosphoenolpyruvate:sugar phosphotransferase system enzyme I, PTS system EI component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (577 aa)
pyrGCTP synthetase (UTP-ammonia lyase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (536 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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