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fbaA fbaA tpx tpx galR galR ahpC ahpC gapN gapN ptsI ptsI pfl2 pfl2 cshB cshB pfl pfl ldh ldh ciaR ciaR pfk pfk rpiA rpiA eno eno gyrB gyrB budC budC aldB aldB covR covR ccpA ccpA ackA ackA rpoB rpoB ptsG ptsG recA recA tkt tkt pgi pgi pgk pgk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fbaABest Blastp Hit: dbj|BAB16889.1| (AB050113) class-II aldolase [Streptococcus bovis]. (293 aa)
tpxThiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (161 aa)
galRBest Blastp Hit: pir||JC5310 galactose repressor - Streptococcus mutans. (334 aa)
ahpCAlkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (186 aa)
gapNBest Blastp Hit: sp|Q59931|GAPN_STRMU NADP-DEPENDENT GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (NON-PHOSPHORYLATING GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE) (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE [NADP+]) (TRIOSEPHOSPHATE DEHYDROGENASE) >gi|2117515|pir||A57151 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (EC 1.2.1.9) - Streptococcus mutans >gi|5822059|pdb|1EUH|A Chain A, Apo Form Of A Nadp Dependent Aldehyde Dehydrogenase From Streptococcus Mutans >gi|5822060|pdb|1EUH|B Chain B, Apo Form Of A Nadp Dependent Aldehyde Dehydrogenase From Streptococcus Mutans >gi|5822061|pdb|1EUH|C [...] (475 aa)
ptsIPhosphoenolpyruvate:sugar phosphotransferase system enzyme I, PTS system EI component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (577 aa)
pfl2Best Blastp Hit: sp|P75793|PFLF_ECOLI PUTATIVE FORMATE ACETYLTRANSFERASE 3 (PYRUVATE FORMATE-LYASE 3) >gi|7427871|pir||G64819 probable formate C-acetyltransferase (EC 2.3.1.54) - Escherichia coli >gi|1787044|gb|AAC73910.1| (AE000184) putative formate acetyltransferase [Escherichia coli] >gi|4062397|dbj|BAA35511.1| (D90720) Formate acetyltransferase 2 (EC 2.3.1.54) (pyruvate formate-lyase 2). [Escherichia coli]. (818 aa)
cshBPutative ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa)
pflPyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans]. (775 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
ciaRBest Blastp Hit: emb|CAB54564.1| (AJ005926) response regulator [Streptococcus pneumoniae]. (224 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
rpiAPutative ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family. (432 aa)
gyrBPutative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (650 aa)
budCPutative acetoin dehydrogenase; Best Blastp Hit: gb|AAC48769.1| (U71200) acetoin reductase [Bos taurus]. (254 aa)
aldBBest Blastp Hit: emb|CAA57941.1| (X82620) alpha-acetolactate decarboxylase [Lactococcus lactis]. (238 aa)
covRPutative response regulator CovR; Best Blastp Hit: emb|CAB65451.1| (AJ012051) VicR protein [Streptococcus pyogenes]. (235 aa)
ccpACatabolite control protein A, CcpA; Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. (333 aa)
ackAPutative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
rpoBDNA-dependent RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1187 aa)
ptsGPutative PTS system, glucose-specific IIABC component; Best Blastp Hit: gb|AAD00281.1| (U78600) putative ptsG## protein [Streptococcus mutans]. (729 aa)
recARecombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (383 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa)
pgiGlucose-6-phosphate isomerase; Best Blastp Hit: gb|AAD33517.1|AF132127_2 (AF132127) glucose-6-phosphate isomerase [Streptococcus mutans]. (449 aa)
pgkPhosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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