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ffh ffh ciaH ciaH ciaR ciaR lacD2 lacD2 lacD lacD SMU_150 SMU_150 SMU_151 SMU_151 SMU_1609c SMU_1609c livF livF livG livG livM livM livH livH livK livK yidC2 yidC2 SMU_1787c SMU_1787c aroG aroG aroH aroH secA secA SMU_1881c SMU_1881c SMU_1898 SMU_1898 SMU_1900 SMU_1900 SMU_1913c SMU_1913c SMU_1914c SMU_1914c comC comC comD comD comE comE secE secE comX1 comX1 secY secY oppA oppA oppB oppB oppC oppC oppD oppD oppF oppF aguD aguD SMU_286 SMU_286 SMU_287 SMU_287 yidC1 yidC1 SMU_423 SMU_423 luxS luxS trpE trpE trpG trpG SMU_61 SMU_61 mutF mutF mutE1 mutE1 mutE2 mutE2 mutG mutG SMU_659 SMU_659 SMU_660 SMU_660 ftsY ftsY SMU_925 SMU_925
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ffhSignal recognition particle protein subunit, Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. (516 aa)
ciaHPutative histidine kinase sensor CiaH; Best Blastp Hit: sp|Q54955|CIAH_STRPN SENSOR PROTEIN CIAH >gi|1363426|pir||S49545 histidine kinase - Streptococcus pneumoniae >gi|495277|emb|CAA54466.1| (X77249) histidine kinase [Streptococcus pneumoniae] >gi|5830518|emb|CAB54565.1| (AJ005926) histidine kinase [Streptococcus pneumoniae]. (435 aa)
ciaRBest Blastp Hit: emb|CAB54564.1| (AJ005926) response regulator [Streptococcus pneumoniae]. (224 aa)
lacD2Tagatose 1,6-aldolase; Best Blastp Hit: sp|P26425|LACD_STRMU TAGATOSE 1,6-DIPHOSPHATE ALDOLASE (TAGATOSE-BISPHOSPHATE ALDOLASE) (D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE) >gi|322120|pir||F43258 tagatose-1,6-bisphosphate aldolase homolog LacD - Streptococcus mutans >gi|153676|gb|AAA26907.1| (M80797) tagatose 1,6-aldolase [Streptococcus mutans]. (329 aa)
lacDTagatose-1,6-bisphosphate aldolase; Best Blastp Hit: sp|P26425|LACD_STRMU TAGATOSE 1,6-DIPHOSPHATE ALDOLASE (TAGATOSE-BISPHOSPHATE ALDOLASE) (D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE) >gi|322120|pir||F43258 tagatose-1,6-bisphosphate aldolase homolog LacD - Streptococcus mutans >gi|153676|gb|AAA26907.1| (M80797) tagatose 1,6-aldolase [Streptococcus mutans]. (325 aa)
SMU_150Hypothetical protein; Best Blastp Hit: gb|AAG29818.1|AF298196_1 (AF298196) bovicin 255 peptide precursor [Streptococcus sp. LRC 0255]. (67 aa)
SMU_151Hypothetical protein; Best Blastp Hit: sp|Q48509|LAFX_LACJO BACTERIOCIN LACTACIN F, SUBUNIT LAFX PRECURSOR >gi|149570|gb|AAA16637.1| (M57961) role in the expression of lactacin F, part of the laf operon [Lactobacillus sp.]. (78 aa)
SMU_1609cPutative membrane protein involved in protein secretion, SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (78 aa)
livFBest Blastp Hit: pir||T35757 probable branched chain amino acid transport ATP-binding protein - Streptomyces coelicolor >gi|5689905|emb|CAB52068.1| (AL109732) putative branched chain amino acid transport ATP-binding protein [Streptomyces coelicolor A3(2)]. (236 aa)
livGBest Blastp Hit: pir||F72290 branched chain amino acid ABC transporter, ATP-binding protein - Thermotoga maritima (strain MSB8) >gi|4981685|gb|AAD36214.1|AE001771_7 (AE001771) branched chain amino acid ABC transporter, ATP-binding protein [Thermotoga maritima]. (254 aa)
livMBest Blastp Hit: pir||E72290 branched chain amino acid ABC transporter, permease protein - Thermotoga maritima (strain MSB8) >gi|4981684|gb|AAD36213.1|AE001771_6 (AE001771) branched chain amino acid ABC transporter, permease protein [Thermotoga maritima]. (318 aa)
livHBest Blastp Hit: pir||D72290 branched chain amino acid ABC transporter, permease protein - Thermotoga maritima (strain MSB8) >gi|4981683|gb|AAD36212.1|AE001771_5 (AE001771) branched chain amino acid ABC transporter, permease protein [Thermotoga maritima]. (289 aa)
livKBest Blastp Hit: pir||C72290 branched chain amino acid ABC transporter, periplasmic amino acid-binding protein - Thermotoga maritima (strain MSB8) >gi|4981682|gb|AAD36211.1|AE001771_4 (AE001771) branched chain amino acid ABC transporter, periplasmic amino acid-binding protein [Thermotoga maritima]. (390 aa)
yidC2Putative inner membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment. (310 aa)
SMU_1787cPutative secreted protein; Best Blastp Hit: dbj|BAA11328.1| (D78257) ORF11 [Enterococcus faecalis]. (127 aa)
aroGPutative DAHP synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (344 aa)
aroHPutative DAHP synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (343 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (839 aa)
SMU_1881cPutative ABC transporter, ATP-binding protein; Best Blastp Hit: sp|Q03727|COMA_STRPN TRANSPORT ATP-BINDING PROTEIN COMA >gi|520738|gb|AAA69510.1| (M36180) comA protein [Streptococcus pneumoniae]. (763 aa)
SMU_1898Putative ABC transporter, ATP-binding and permease protein; Best Blastp Hit: sp|Q03727|COMA_STRPN TRANSPORT ATP-BINDING PROTEIN COMA >gi|520738|gb|AAA69510.1| (M36180) comA protein [Streptococcus pneumoniae]. (503 aa)
SMU_1900Conserved hypothetical protein; Best Blastp Hit: emb|CAC03518.1| (AJ276410) BlpB protein [Streptococcus pneumoniae]. (337 aa)
SMU_1913cPutative immunity protein, BLpL-like; Best Blastp Hit: emb|CAC03523.1| (AJ276410) BlpL protein [Streptococcus pneumoniae]. (133 aa)
SMU_1914cHypothetical protein; Best Blastp Hit: emb|CAC03526.1| (AJ276410) BlpO protein [Streptococcus pneumoniae]. (76 aa)
comCCompetence stimulating peptide, precursor. (46 aa)
comDPutative histidine kinase of the competence regulon, ComD; Best Blastp Hit: emb|CAC10175.1| (AJ278302) histidine kinase [Streptococcus pneumoniae]. (441 aa)
comEPutative response regulator of the competence regulon, ComE; Best Blastp Hit: gb|AAB41200.1| (U75483) sakacin A production response regulator [Streptococcus mutans]. (250 aa)
secEPutative preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. (58 aa)
comX1Putative ComX1, transcriptional regulator of competence-specific genes; Best Blastp Hit: gb|AAD50427.1|AF161700_2 (AF161700) ComX1 [Streptococcus pneumoniae] >gi|5739315|gb|AAD50429.1|AF161701_2 (AF161701) ComX2 [Streptococcus pneumoniae]. (160 aa)
secYPutative preprotein translocase SecY protein; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (434 aa)
oppAPutative oligopeptide ABC transporter, substrate-binding protein OppA; Best Blastp Hit: gb|AAD17886.1| (AF100456) hyaluronate-associated protein precursor [Streptococcus equi]. (549 aa)
oppBPutative oligopeptide transport system, permease protein OppB; Best Blastp Hit: gb|AAF73091.1|AF103793_2 (AF103793) transmembrane protein OppB [Listeria monocytogenes]. (304 aa)
oppCPutative transmembrane protein, permease OppC; Best Blastp Hit: gb|AAF73092.1|AF103793_3 (AF103793) transmembrane protein OppC [Listeria monocytogenes]. (343 aa)
oppDPutative oligopeptide ABC transporter, ATP-binding protein OppD; Best Blastp Hit: gb|AAF73093.1|AF103793_4 (AF103793) ATPase OppD [Listeria monocytogenes]; Belongs to the ABC transporter superfamily. (350 aa)
oppFPutative oligopeptide ABC transporter, ATP-binding protein OppF; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily. (308 aa)
aguDPutative amino acid antiporter; Best Blastp Hit: gb|AAG08190.1|AE004893_8 (AE004893) probable amino acid permease [Pseudomonas aeruginosa]. (452 aa)
SMU_286Best Blastp Hit: sp|Q03727|COMA_STRPN TRANSPORT ATP-BINDING PROTEIN COMA >gi|520738|gb|AAA69510.1| (M36180) comA protein [Streptococcus pneumoniae]. (760 aa)
SMU_287Putative ComB, accessory factor for ComA; Best Blastp Hit: emb|CAC03518.1| (AJ276410) BlpB protein [Streptococcus pneumoniae]. (300 aa)
yidC1Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment. (271 aa)
SMU_423Hypothetical protein; Best Blastp Hit: gb|AAG29818.1|AF298196_1 (AF298196) bovicin 255 peptide precursor [Streptococcus sp. LRC 0255]. (76 aa)
luxSPutative autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (160 aa)
trpEPutative anthranilate synthase, alpha subunit; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and h [...] (453 aa)
trpGPutative anthranilate synthase, beta subunit; Best Blastp Hit: sp|Q02003|TRPG_LACLA ANTHRANILATE SYNTHASE COMPONENT II (GLUTAMINE AMIDO-TRANSFERASE) >gi|421418|pir||S35125 anthranilate synthase (EC 4.1.3.27) beta chain - Lactococcus lactis subsp. lactis >gi|551880|gb|AAA25224.1| (M87483) anthranilate synthase beta subunit [Lactococcus lactis]. (187 aa)
SMU_61Putative transcriptional regulator; Best Blastp Hit: gb|AAC03457.1| (AF020798) repressor [Streptococcus thermophilus bacteriophage TP-J34]. (304 aa)
mutFPutative ABC transporter, ATP-binding protein MutF; Best Blastp Hit: gb|AAF99691.1|AF267498_1 (AF267498) MutF [Streptococcus mutans]. (234 aa)
mutE1Putative MutE; Best Blastp Hit: gb|AAF99692.1|AF267498_2 (AF267498) MutE [Streptococcus mutans]. (82 aa)
mutE2Putative MutE; Best Blastp Hit: gb|AAF99692.1|AF267498_2 (AF267498) MutE## [Streptococcus mutans]. (171 aa)
mutGPutative MutG; Best Blastp Hit: gb|AAF99693.1|AF267498_3 (AF267498) MutG [Streptococcus mutans]. (248 aa)
SMU_659Best Blastp Hit: emb|CAA11808.1| (AJ224003) response regulator [Carnobacterium divergens]. (219 aa)
SMU_660Putative histidine kinase SpaK; Best Blastp Hit: sp|P33113|SPAK_BACSU SUBTILIN BIOSYNTHESIS SENSOR PROTEIN SPAK >gi|2702244|gb|AAB91593.1| (U09819) SpaK [Bacillus subtilis]. (460 aa)
ftsYPutative cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC); Belongs to the GTP-binding SRP family. FtsY subfamily. (498 aa)
SMU_925Hypothetical protein; Best Blastp Hit: emb|CAC03523.1| (AJ276410) BlpL protein [Streptococcus pneumoniae]. (156 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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