STRINGSTRING
ygfZ ygfZ bolA bolA SO_1846 SO_1846 SO_1848 SO_1848 SO_1849 SO_1849 SO_1850 SO_1850 iscR iscR iscS iscS iscU iscU iscA iscA hscB hscB hscA hscA fdx fdx iscX iscX grxD grxD djlA djlA cyaY cyaY nfuA nfuA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ygfZFolate-dependent protein involved in synthesis and repair of FeS clusters YgfZ; Belongs to the GcvT family. (318 aa)
bolAGlobal transcriptional regulator BolA; Belongs to the BolA/IbaG family. (106 aa)
SO_1846Uncharacterized protein. (298 aa)
SO_1848Uncharacterized protein. (252 aa)
SO_1849Uncharacterized protein. (179 aa)
SO_1850DnaJ domain protein. (94 aa)
iscRTranscriptional repressor of iron-sulfur cluster assembly genes IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (153 aa)
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (404 aa)
iscUFeS cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (127 aa)
iscAFeS cluster assembly acessory protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. (107 aa)
hscBCo-chaperone Hsc20 HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (174 aa)
hscAChaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (620 aa)
fdxFerredoxin 2Fe-2S type ISC system Fdx. (111 aa)
iscXFeS assembly protein IscX. (65 aa)
grxDMonothiol glutaredoxin GrxD; Belongs to the glutaredoxin family. Monothiol subfamily. (110 aa)
djlADnaK co-chaperone DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. (262 aa)
cyaYIron donor for FeS cluster assembly CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (109 aa)
nfuAIron-sulfur cluster biogenesis scaffold protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (192 aa)
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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