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argC argC argB argB argF argF argG argG argH argH ilvE ilvE argD argD argR argR dapB dapB purA-2 purA-2 dapD dapD dapA dapA iaaA iaaA ilvH ilvH ilvI ilvI ansA ansA dapE dapE yfbQ yfbQ ldh ldh asnB asnB asd asd thrC thrC thrB thrB thrA thrA SO_3427 SO_3427 purA purA lysC lysC metL metL leuD leuD leuC leuC leuB leuB leuA leuA argA argA dapF dapF lysA lysA ilvA ilvA ilvD ilvD ilvM ilvM ilvG ilvG ilvC ilvC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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argCN-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (326 aa)
argBAcetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (260 aa)
argFOrnithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa)
argGArgininosuccinate synthase ArgG; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (407 aa)
argHArgininosuccinate lyase ArgH. (455 aa)
ilvEBranched-chain-amino-acid transaminase IlvE. (363 aa)
argDBifunctional acetylornithine aminotransferase/succinyl-diaminopimelate aminotransferase/succinylornithine transaminase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
argRArginine-responsive transcriptional repressor of arginine metabolism ArgR; Regulates arginine biosynthesis genes. (156 aa)
dapBDihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (270 aa)
purA-2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (418 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase DapD; Belongs to the transferase hexapeptide repeat family. (274 aa)
dapADihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
iaaABifunctional isoaspartyl dipeptidase / l-asparaginase IaaA. (343 aa)
ilvHAcetolactate synthase III small subunit IlvH. (164 aa)
ilvIAcetolactate synthase III large subunit IlvI. (572 aa)
ansAL-asparaginase I AnsA. (337 aa)
dapESuccinyl-diaminopimelate desuccinylase DapE; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (384 aa)
yfbQPLP-dependent aminotransferase YfbQ. (404 aa)
ldhLeucine dehydrogenase Ldh. (344 aa)
asnBAsparagine synthase glutamine-hydrolyzing AsnB. (554 aa)
asdAspartate semialdehyde dehydrogenese Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
thrCThreonine synthase ThrC. (427 aa)
thrBHomoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa)
thrABifunctional aspartokinase I / homoserine dehydrogenase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. (822 aa)
SO_3427Lysine-sensitive monofunctional aspartokinase LysC family; Belongs to the aspartokinase family. (418 aa)
purAAdenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
lysCLysine-sensitive aspartokinase III LysC; Belongs to the aspartokinase family. (451 aa)
metLBifunctional aspartokinase II/homoserine dehydrogenase methionine-sensitive MetL; In the C-terminal section; belongs to the homoserine dehydrogenase family. (797 aa)
leuD3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuC3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
leuB3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (364 aa)
leuA2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (522 aa)
argAAmino-acid acetyltransferase ArgA; Belongs to the acetyltransferase family. ArgA subfamily. (445 aa)
dapFDiaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa)
lysADiaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
ilvAThreonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (545 aa)
ilvDDihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (619 aa)
ilvMAcetolactate synthase II small subunit IlvM. (86 aa)
ilvGAcetolactate synthase II large subunit IlvG. (552 aa)
ilvCKetol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (492 aa)
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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