STRINGSTRING
recQ recQ dnaA dnaA SO_0026 SO_0026 nsrR nsrR rplB rplB prpR prpR fis fis SO_0502 SO_0502 arsR arsR prrA prrA SO_0548 SO_0548 SO_0595 SO_0595 dnaG dnaG yfjY yfjY hupB hupB SO_1815 SO_1815 SO_1817 SO_1817 SO_1863 SO_1863 ihfA ihfA SO_2308 SO_2308 seqA seqA SO_2380 SO_2380 hexR hexR O O hlyU hlyU SO_3743 SO_3743 SO_3787 SO_3787 SO_3888 SO_3888 dnaB dnaB priB priB priA priA hda hda hypR hypR com-2 com-2 psrA psrA nemR nemR yicR yicR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
recQATP-dependent DNA helicase RecQ. (607 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (460 aa)
SO_0026Transcriptional regulator ArsR family. (102 aa)
nsrRNitrite-sensitive transcriptional repressor NsrR. (151 aa)
rplB50S ribosomal protein L2 RplB; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
prpRMethycitrate-responsive transcriptional regulator of methylisocitrate utilization PrpR. (254 aa)
fisGlobal transcriptional activator Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (101 aa)
SO_0502Transcriptional regulator ArsR family. (111 aa)
arsRArsenite-sensing transcriptional repressor ArsR. (114 aa)
prrATwo-component system, response regulator RegA; Oxygen-responsive two component signal transduction system controlling redox affected systems response regulator PrrA. (183 aa)
SO_0548Histone-like DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
SO_0595Protein of unknown function. (151 aa)
dnaGDNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (574 aa)
yfjYProtein of unknown function DUF2466 YfjY; Belongs to the UPF0758 family. (157 aa)
hupBHistone-like DNA-binding protein HupB; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
SO_1815Histone deacetylase superfamily protein. (304 aa)
SO_1817Primosomal replication protein N'-like protein. (220 aa)
SO_1863Histone-like DNA-binding protein; Belongs to the bacterial histone-like protein family. (91 aa)
ihfAIntegration host factor alpha subunit IhfA; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (98 aa)
SO_2308AAA ATPase family protein. (443 aa)
seqANegative regulator of DNA replication SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. (183 aa)
SO_2380ATP-dependent DNA helicase RecQ family. (654 aa)
hexRRpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. (284 aa)
OLambda phage replication protein O. (356 aa)
hlyUTranscriptional activator HlyU. (98 aa)
SO_3743Transcriptional regulator TetR family. (159 aa)
SO_3787Protein of unknown function. (228 aa)
SO_3888Protein of unknown function DUF1508; Belongs to the UPF0339 family. Duplicated subfamily. (110 aa)
dnaBReplicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (468 aa)
priBPrimosomal replication protein N PriB; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family. (101 aa)
priAPrimosomal replication protein N' PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (737 aa)
hdaDnaA regulatory inactivator Hda; Belongs to the DnaA family. (236 aa)
hypRTranscriptional regulator of proline and 4-hydroxyproline utilization HypR. (223 aa)
com-2Mu phage Mom translational regulator Com. (71 aa)
psrATranscriptional repressor of fatty acid degradation PsrA. (213 aa)
nemRTranscriptional repressor of N-ethylmaleimide reductase NemR. (198 aa)
yicRProtein of unknown function DUF2466 YicR; Belongs to the UPF0758 family. (225 aa)
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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