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| | fadA | Aerobic fatty oxidation complex 3-ketoacyl-CoA thiolase beta subunit FadA; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa) |
| | fadB | Aerobic fatty oxidation complex 3-hydroxyacyl-CoA epimerase alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (716 aa) |
| | hemG | Oxygen-independent protoporphyrinogen oxidase HemG. (174 aa) |
| | hemG-2 | Oxygen-independent protoporphyrinogen oxidase HemG. (184 aa) |
| | hemF | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (302 aa) |
| | aroE | Shikimate 5-dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa) |
| | gpmA | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase GpmA; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NADP+) GpsA; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa) |
| | deoD | Purine nucleoside phosphorylase DeoD. (236 aa) |
| | ubiC | Chorismate-pyruvate lyase UbiC; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (189 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase RibB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase PckA; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (513 aa) |
| | yrfG | HAD-superfamily hydrolase subfamily IA variant 3 protein family YrfG. (220 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (326 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (260 aa) |
| | argF | Ornithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa) |
| | argG | Argininosuccinate synthase ArgG; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (407 aa) |
| | argH | Argininosuccinate lyase ArgH. (455 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | rpe | Ribulose-phosphate 3-epimerase Rpe; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | gph | 2-phosphoglycolate phosphatase Gph; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (227 aa) |
| | speF | Ornithine decarboxylase SpeF. (720 aa) |
| | ilvE | Branched-chain-amino-acid transaminase IlvE. (363 aa) |
| | yjjG | 5' nucleotide phosphatase YjjG. (234 aa) |
| | frdC | Quinol:fumarate reductase menaquinol-oxidizing subunit FrdC. (241 aa) |
| | frdC-2 | Quinol:fumarate reductase menaquinol-oxidizing subunit FrdC. (223 aa) |
| | frdA | Quinol:fumarate reductase FAD-binding subunit FrdA. (668 aa) |
| | frdB | Quinol:fumarate reductase FeS subunit FrdB. (243 aa) |
| | aceE | Pyruvate dehydrogenase E1 component AceE; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (888 aa) |
| | aceF | Dihydrolipoamide acetyltransferase AceF; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (677 aa) |
| | lpdA | Dihydrolipoamide dehydrogenase LpdA. (475 aa) |
| | acnB | Aconitate hydratase AcnB; Belongs to the aconitase/IPM isomerase family. (865 aa) |
| | hemE | Uroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | purD | Phosphoribosylamine-glycine ligase PurD; Belongs to the GARS family. (432 aa) |
| | purH | Bifunctional IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase PurH. (543 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase UbiA; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (286 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (488 aa) |
| | accB | acetyl-CoA carboxylase biotin carboxyl carrier protein AccB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa) |
| | aroQ | 3-dehydroquinate dehydratase type II AroQ; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase (NAD+) GapA; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa) |
| | plsC | 1-acyl-sn-glycerol-3-phosphate acyltransferase PlsC; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (247 aa) |
| | psd | Phosphatidylserine decarboxylase Psd; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (292 aa) |
| | miaA | tRNA dimethylallyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (308 aa) |
| | argD | Bifunctional acetylornithine aminotransferase/succinyl-diaminopimelate aminotransferase/succinylornithine transaminase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa) |
| | galM | Aldose 1-epimerase GalM; Converts alpha-aldose to the beta-anomer. (343 aa) |
| | katG | Bifunctional catalase/peroxidase HPI KatG; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (741 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase phe-sensitive AroG; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (352 aa) |
| | mdh | NAD dependent malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa) |
| | ubiH | 2-octaprenyl-6-methoxyphenol hydroxylase UbiH. (407 aa) |
| | visC | FAD-dependent hydroxylase VisC. (407 aa) |
| | gcvT | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. (364 aa) |
| | gcvH | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa) |
| | metE | B12-independent 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (760 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa) |
| | panC | Pantoate--beta-alanine ligase PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa) |
| | metK | S-adenosylmethionine synthetase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa) |
| | tkt | Transketolase Tkt; Belongs to the transketolase family. (664 aa) |
| | e4pd | D-erythrose-4-phosphate dehydrogenase E4pd; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (338 aa) |
| | pgk | Phosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (391 aa) |
| | fba | Fructose-bisphosphate aldolase class II Calvin cycle subtype Fba; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (355 aa) |
| | fccA | Periplasmic fumarate reductase FccA; Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron transfer from formate to fumarate and possibly also to trimethylamine oxide (TMAO). This enzyme is essentially unidirectional (By similarity); In the C-terminal section; belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (596 aa) |
| | glpD | Aerobic glycerol-3-phosphate dehydrogenase GlpD. (391 aa) |
| | metH | B12-dependent 5-methyltetrahydrofolate--homocysteine methyltransferase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1244 aa) |
| | katB | Catalase HPII KatB; Belongs to the catalase family. (486 aa) |
| | proB | Glutamate 5-kinase ProB; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa) |
| | proA | Gamma-glutamyl phosphate reductase ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (425 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (270 aa) |
| | rpiA | Ribose 5-phosphate isomerase RpiA; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | ubiF | 2-octaprenyl-3-methyl-6-methoxy-14-benzoquinone hydroxylase UbiF. (404 aa) |
| | tpiA | Triosephosphate isomeraseTpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa) |
| | deoD-2 | Purine nucleoside phosphorylase DeoD. (236 aa) |
| | serB | Phosphoserine phosphatase SerB. (330 aa) |
| | plyY | acyl-PO4 glycerol-3-phosphate acyltransferase PlsY; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (203 aa) |
| | hemL | Glutamate-1-semialdehyde-21-aminomutase HemL. (430 aa) |
| | gltD | NADPH-dependent glutamate synthase small subunit GltD. (468 aa) |
| | gltB | NADPH-dependent glutamate synthase large subunit GltB. (1482 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase tyr-sensitive AroF; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (363 aa) |
| | tyrA | Bifunctional chorismate mutase T/prephenate dehydrogenase TyrA. (379 aa) |
| | pheA | Multifunctional chorismate mutase P/prephenate dehydratase/DAHP synthetase PheA. (671 aa) |
| | ifcA | Periplasmic tetraheme flavocytochrome IfcA; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa) |
| | aceB | Malate synthase A AceB. (549 aa) |
| | aceA | Isocitrate lyase AceA. (440 aa) |
| | adhB | Alcohol dehydrogenase II AdhB. (382 aa) |
| | malQ | 4-alpha-glucanotransferase MalQ. (769 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme GlgB; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (745 aa) |
| | glgX | Glycogen isoamylase GlgX; Belongs to the glycosyl hydrolase 13 family. (750 aa) |
| | glgP | Glycogen phosphorylase GlgP; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (837 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase GlgC; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (420 aa) |
| | glgA | Glycogen synthase ADP-glucose transglucosylase GlgA. (534 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase Dxs; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (622 aa) |
| | ispA | Geranyl-diphosphate synthase/farnesyl-diphosphate synthase IspA; Belongs to the FPP/GGPP synthase family. (293 aa) |
| | SO_1538 | Isocitrate dehydrogenase NAD-dependent. (335 aa) |
| | uppS | Undecaprenyl diphosphate synthase UppS; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (275 aa) |
| | cdsA | Phosphatidate cytidylyltransferase CdsA; Belongs to the CDS family. (285 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (396 aa) |
| | SO_1653 | dTDP-4-dehydrorhamnose reductase family; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (328 aa) |
| | hexA | D-hexose 6-phosphotransferase HexA. (306 aa) |
| | galU | UTP-glucose-1-phosphate uridylyltransferase GalU. (302 aa) |
| | metA | Homoserine O-succinyltransferase MetA; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (313 aa) |
| | ivdA | 3-ketoacyl-CoA thiolase IvdA; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | ivdG | 3-hydroxyacyl-CoA dehydrogenase IvdG. (252 aa) |
| | SO_1755 | Phosphoglucomutase/phosphomannomutase family protein. (573 aa) |
| | SO_1769 | Glutamate decarboxylase. (549 aa) |
| | garK | Glycerate kinase GarK; Belongs to the glycerate kinase type-1 family. (384 aa) |
| | fabV | Enoyl acyl-carrier-protein reductase FabV; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (400 aa) |
| | dapA | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | liuE | 3-hydroxymethylglutaryl-CoA lyase LiuE. (315 aa) |
| | gnd | 6-phosphogluconate dehydrogenase decarboxylating Gnd; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (508 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (291 aa) |
| | gltA | Citrate synthase GltA; Belongs to the citrate synthase family. (428 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b556 subunit SdhC. (131 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit SdhA; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur protein SdhB; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (235 aa) |
| | sucA | 2-oxoglutarate dehydrogenase complex dehydrogenase E1 component SucA. (939 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (395 aa) |
| | sucC | succinyl-CoA synthase beta subunit SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | sucD | succinyl-CoA synthase alpha subunit SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | nadR | Ribose phosphate pyrophosphokinase NadR; Belongs to the ribose-phosphate pyrophosphokinase family. (301 aa) |
| | ushA | Bifunctional UDP-sugar hydrolase/5'-nucleotidase UshA; Belongs to the 5'-nucleotidase family. (569 aa) |
| | adk | Adenylate kinase Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | hemH | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (334 aa) |
| | frmA | S-(hydroxymethyl)glutathione dehydrogenase FrmA; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (379 aa) |
| | hisIE | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. (211 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase glutamine amidotransferase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (221 aa) |
| | hisB | Bifunctional imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (363 aa) |
| | hisC | Histidinol-phosphate aminotransferase HisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (391 aa) |
| | hisD | Histidinol dehydrogenase HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | hisG | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (324 aa) |
| | iaaA | Bifunctional isoaspartyl dipeptidase / l-asparaginase IaaA. (343 aa) |
| | adhE | Aldehyde-alcohol dehydrogenase AdhE; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (866 aa) |
| | metC | Cystathionine beta-lyase MetC. (399 aa) |
| | dgkA | Diacylglycerol kinase DgkA; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (123 aa) |
| | algA | Alpha-glucosidase AlgA. (540 aa) |
| | fumB | Anaerobic fumarate hydratase FumB; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (516 aa) |
| | sdaA | L-serine ammonia-lyase SdaA; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | suhB | Inositol-phosphate phosphatase SuhB; Belongs to the inositol monophosphatase superfamily. (267 aa) |
| | cysE | Serine acetyltransferase CysE. (273 aa) |
| | ndk | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | ilvH | Acetolactate synthase III small subunit IlvH. (164 aa) |
| | ilvI | Acetolactate synthase III large subunit IlvI. (572 aa) |
| | ribC | 6,7-dimethyl-8-ribityllumazine synthase alpha subunit RibC. (206 aa) |
| | pgm | Phosphoglucomutase alpha-D-glucose phosphate-specific Pgm. (550 aa) |
| | bkdA1 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1. (392 aa) |
| | bkdA2 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. (325 aa) |
| | bkdB | 3-methyl-2-oxobutanoate dehydrogenase complex E2 component BkdB. (535 aa) |
| | gapA-2 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+) GapA; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase GapB; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (477 aa) |
| | aspC | Aspartate aminotransferase AspC. (397 aa) |
| | pssA | Phosphatidylserine synthase PssA. (437 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | aspC-2 | Aspartate aminotransferase AspC. (396 aa) |
| | serC | Bifunctional 3-phosphoserine aminotransferase/phosphohydroxythreonine SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (365 aa) |
| | ubiG | Ubiquinone biosynthesis O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (236 aa) |
| | ansA | L-asparaginase I AnsA. (337 aa) |
| | susB | Alpha-glucosidase SusB. (699 aa) |
| | yfbQ | PLP-dependent aminotransferase YfbQ. (404 aa) |
| | pgl | 6-phosphogluconolactonase Pgl; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (232 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase Zwf; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa) |
| | pykA | Pyruvate kinase II PykA; Belongs to the pyruvate kinase family. (479 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. (333 aa) |
| | icd | Isocitrate dehydrogenase NADP-dependent Icd; Belongs to the monomeric-type IDH family. (741 aa) |
| | purB | Adenylosuccinate lyase PurB; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | ldh | Leucine dehydrogenase Ldh. (344 aa) |
| | ppsA | Phosphoenolpyruvate synthase PpsA; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase trp-sensitive AroH; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (354 aa) |
| | deoD-3 | Purine nucleoside phosphorylase DeoD. (234 aa) |
| | acs | Acetyl-coenzyme A synthetase AcsA; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase PurM. (345 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (214 aa) |
| | asnB | Asparagine synthase glutamine-hydrolyzing AsnB. (554 aa) |
| | SO_2769 | Aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (282 aa) |
| | acpP | Acyl carrier protein AcpP; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa) |
| | fabG | 3-oxoacyl-(acyl-carrier-protein) reductase FabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase FabD. (308 aa) |
| | plsX | phosphate:acyl-ACP acyltransferase PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | SO_2813 | Oxidoreductase short chain dehydrogenase/reductase family. (249 aa) |
| | ribA | GTP cyclohydrolase II RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (203 aa) |
| | cysK | Cysteine synthase CysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | trpE | Anthranilate synthase component I TrpE. (574 aa) |
| | trpG | Anthranilate synthase component II glutamine amido-transferase TrpG. (202 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (347 aa) |
| | trpCF | Bifunctional indole-3-glycerolphosphate synthetase/phosphoribosylanthranilate isomerase TrpCF; Belongs to the TrpC family. (498 aa) |
| | trpB | Tryptophan synthase beta subunit TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase alpha subunit TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | pubA | Putrescine monooxygenase PubA. (498 aa) |
| | purF | Amidophosphoribosyltransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (504 aa) |
| | asd | Aspartate semialdehyde dehydrogenese Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | fadJ | Anaerobic fatty oxidation complex alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (705 aa) |
| | fadI | Anaerobic fatty oxidation complex beta subunit FadI; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa) |
| | SO_3108 | Bifunctional 13-dimethyluroporphyrinogen III dehydrogenase/siroheme ferrochelatase. (303 aa) |
| | gltX | glutamyl-tRNA synthetase GltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (469 aa) |
| | rfbc | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (179 aa) |
| | rffG | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (343 aa) |
| | wbpQ | Asparagine synthase glutamine-hydrolyzing WbpQ. (643 aa) |
| | rmlA | Glucose-1-phosphate-thymidylyltransferase RmlA; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (304 aa) |
| | rfbB | dTDP-glucose-4,6-dehydratase RfbB. (375 aa) |
| | SO_3262 | TPP-dependent enzyme involved in flagella modificaiton. (581 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase PurL; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1293 aa) |
| | guaB | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (371 aa) |
| | SO_3317 | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (583 aa) |
| | ybjU | Threonine aldolase YbjU. (337 aa) |
| | hemH2 | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (327 aa) |
| | proC | Pyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | thrC | Threonine synthase ThrC. (427 aa) |
| | thrB | Homoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa) |
| | thrA | Bifunctional aspartokinase I / homoserine dehydrogenase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. (822 aa) |
| | SO_3427 | Lysine-sensitive monofunctional aspartokinase LysC family; Belongs to the aspartokinase family. (418 aa) |
| | surE | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa) |
| | ispF | 2-C-methyl-D-erythritol 24-cyclodiphosphate synthase IspF; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity). (159 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (249 aa) |
| | eno | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (431 aa) |
| | ribE | Riboflavin synthase beta subunit RibE; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (158 aa) |
| | ribBA | Bifunctional 34-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (367 aa) |
| | SO_3468 | Riboflavin synthase alpha subunit RibC-like protein. (218 aa) |
| | ribD | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (381 aa) |
| | glyA | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | SO_3513 | Flavin-dependent tryptophan halogenase. (507 aa) |
| | ispH | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (318 aa) |
| | ribF | Bifunctional flavokinase/FAD synthetase RibF; Belongs to the ribF family. (311 aa) |
| | talB | Transaldolase B TalB; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa) |
| | pgi | Glucose-6-phosphate isomerase Pgi. (545 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (365 aa) |
| | pssA-2 | CDP-diacylglycerol--serine O-phosphatidyltransferase PssA; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (269 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2 PurT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (391 aa) |
| | hprA | NADH-dependent hydroxypyruvate reductase HprA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | ispB | Octaprenyl-diphosphate synthase IspB; Belongs to the FPP/GGPP synthase family. (331 aa) |
| | hemG-3 | Oxygen-independent protoporphyrinogen oxidase HemG. (173 aa) |
| | cysN | Sulfate adenylyltransferase large subunit CysN; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (485 aa) |
| | cysD | Sulfate adenylyltransferase small subunit CysD. (302 aa) |
| | cysG | uroporphyrin-III C-methyltransferase CysG; Belongs to the precorrin methyltransferase family. (276 aa) |
| | putA-2 | Bifunctional proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1059 aa) |
| | hprT | Hypoxanthine phosphoribosyltransferase HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate decarboxylase UbiX; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (219 aa) |
| | panE | 2-dehydropantoate 2-reductase PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (327 aa) |
| | hemA | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (416 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase IspE; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (284 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | lysC | Lysine-sensitive aspartokinase III LysC; Belongs to the aspartokinase family. (451 aa) |
| | fbp | Fructose-16-bisphosphatase Fbp. (325 aa) |
| | metL | Bifunctional aspartokinase II/homoserine dehydrogenase methionine-sensitive MetL; In the C-terminal section; belongs to the homoserine dehydrogenase family. (797 aa) |
| | metB | Cystathionine gamma-synthase MetB. (393 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC; Belongs to the SAICAR synthetase family. (367 aa) |
| | speC | Ornithine decarboxylase SpeC; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (391 aa) |
| | SO_4174 | dTDP-4-dehydrorhamnose reductase family; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (306 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa) |
| | hemB-2 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. (336 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | leuB | 3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (364 aa) |
| | leuA | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (522 aa) |
| | argA | Amino-acid acetyltransferase ArgA; Belongs to the acetyltransferase family. ArgA subfamily. (445 aa) |
| | SO_4305 | HAD-superfamily hydrolase subfamily IA variant 1 family protein. (240 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa) |
| | hemC | Hydroxymethylbilane synthase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa) |
| | hemD | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | hemX | uroporphyrin-III C-methyltransferase HemX. (414 aa) |
| | agxT | Serine-pyruvate aminotransferase AgxT. (377 aa) |
| | ilvA | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (545 aa) |
| | ilvD | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (619 aa) |
| | ilvM | Acetolactate synthase II small subunit IlvM. (86 aa) |
| | ilvG | Acetolactate synthase II large subunit IlvG. (552 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (492 aa) |
| | SO_4368 | Acyl carrier protein. (84 aa) |
| | acpP-2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa) |
| | fabG-2 | 3-oxoacyl-(acyl-carrier-protein) reductase FabG. (241 aa) |
| | katG-2 | Bifunctional catalase/peroxidase HPI KatG; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (728 aa) |
| | ppnP | Protein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (103 aa) |
| | exaC | NAD+-dependent acetaldehyde dehydrogenase ExaC; Belongs to the aldehyde dehydrogenase family. (506 aa) |
| | menD | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase MenD; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (573 aa) |
| | menH | 2-succinyl-6-hydroxy-24-cyclohexadiene-1- carboxylate synthase MenH; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (266 aa) |
| | menC | O-succinylbenzoate-CoA synthase MenC; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (374 aa) |
| | menE | O-succinylbenzoic acid CoA ligase MenE. (481 aa) |
| | plsB | Glycerol-3-phosphate O-acyltransferase PlsB; Belongs to the GPAT/DAPAT family. (809 aa) |
| | ctaA | Heme A synthase CtaA. (330 aa) |
| | ctaB | Protoheme IX farnesyltransferase (heme O synthase) CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (300 aa) |
| | glpE | Thiosulfate sulfurtransferase GlpE; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (101 aa) |
| | SO_4706 | Malate synthase domain protein. (187 aa) |
| | menF | Menaquinone-specific isochorismate synthase MenF; Catalyzes the conversion of chorismate to isochorismate. (452 aa) |
| | hemN | Coproporphyrinogen III oxidase oxygen-independent HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (458 aa) |
| | menB | Naphthoate synthase MenB; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (300 aa) |
| | sdhD | Succinate dehydrogenase membrane anchor subunit SdhD; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
