(14 nodes) Tricarboxylic acid cycle network (Anaplasma phagocytophilum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	APH_0042	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. (751 aa)
	sdhA-1	Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (604 aa)
	sdhB-1	Succinate dehydrogenase, iron-sulfur protein; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (262 aa)
	sdhA-2	Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (604 aa)
	sdhB-2	Succinate dehydrogenase, iron-sulfur protein; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384. (262 aa)
	fumC	Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
	mdh	Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (321 aa)
	sdhD	Succinate dehydrogenase, hydrophobic membrane anchor protein; Identified by similarity to GB:AAC17941.1. (109 aa)
	sdhC	Succinate dehydrogenase, cytochrome b556 subunit; Identified by match to protein family HMM PF01127. (127 aa)
	sucC	succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
	sucD	succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
	acnA	Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (873 aa)
	APH_1166	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180. (477 aa)
	gltA	Citrate synthase I; Identified by similarity to SP:P20901; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. (411 aa)

Your Current Organism:

Anaplasma phagocytophilum

NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH_0042	APH_1166	APH_0042	APH_1166	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	0.608
APH_0042	acnA	APH_0042	APH_1117	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.566
APH_0042	fumC	APH_0042	APH_0247	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.979
APH_0042	gltA	APH_0042	APH_1232	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Citrate synthase I; Identified by similarity to SP:P20901; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family.	0.952
APH_0042	mdh	APH_0042	APH_0629	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.979
APH_0042	sdhA-1	APH_0042	APH_0158	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.772
APH_0042	sdhA-2	APH_0042	APH_0161	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.772
APH_0042	sdhB-1	APH_0042	APH_0159	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Succinate dehydrogenase, iron-sulfur protein; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.	0.580
APH_0042	sdhB-2	APH_0042	APH_0162	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Succinate dehydrogenase, iron-sulfur protein; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384.	0.580
APH_0042	sdhC	APH_0042	APH_0999	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Succinate dehydrogenase, cytochrome b556 subunit; Identified by match to protein family HMM PF01127.	0.588
APH_0042	sucC	APH_0042	APH_1052	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.720
APH_0042	sucD	APH_0042	APH_1053	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.649
APH_1166	APH_0042	APH_1166	APH_0042	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.608
APH_1166	acnA	APH_1166	APH_1117	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.	0.965
APH_1166	fumC	APH_1166	APH_0247	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.486
APH_1166	gltA	APH_1166	APH_1232	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Citrate synthase I; Identified by similarity to SP:P20901; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family.	0.783
APH_1166	mdh	APH_1166	APH_0629	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.708
APH_1166	sdhA-1	APH_1166	APH_0158	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.405
APH_1166	sdhA-2	APH_1166	APH_0161	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.405
APH_1166	sdhB-1	APH_1166	APH_0159	Dehydrogenase, isocitrate/isopropylmalate family; Identified by match to protein family HMM PF00180.	Succinate dehydrogenase, iron-sulfur protein; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.	0.412