STRINGSTRING
CTC_00069 CTC_00069 tadA tadA bioB bioB mesJ mesJ CTC_00203 CTC_00203 ftsH ftsH CTC_00206 CTC_00206 coaX coaX nifR nifR CTC_00209 CTC_00209 greA greA cobB cobB cinA cinA hisE hisE CTC_00659 CTC_00659 CTC_00671 CTC_00671 CTC_00672 CTC_00672 ribA ribA ribH ribH nadE nadE CTC_00699 CTC_00699 birA birA CTC_00983 CTC_00983 CTC_01205 CTC_01205 yicC yicC CTC_01217 CTC_01217 priA priA def def fmt fmt CTC_01221 CTC_01221 CTC_01222 CTC_01222 rlmN rlmN CTC_01224 CTC_01224 CTC_01225 CTC_01225 rsgA rsgA CTC_01228 CTC_01228 CTC_01284 CTC_01284 ftsK ftsK rimO rimO nadK nadK bioD bioD greA-2 greA-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
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CTC_00069Predicted NADH pyrophosphatase. (175 aa)
tadACytosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (325 aa)
mesJCell cycle protein mesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (467 aa)
CTC_00203Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
ftsHCell division protein ftsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (603 aa)
CTC_00206Dihydrolipoamide acyltransferase. (127 aa)
coaXPutative transcriptional regulator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (262 aa)
nifRNitrogen regulation protein nifR3; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (322 aa)
CTC_00209Hypothetical protein. (287 aa)
greATranscription elongation factor greA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (186 aa)
cobBRegulatory protein, sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (247 aa)
cinAPutative competence-damage protein; Belongs to the CinA family. (409 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (107 aa)
CTC_00659Alkaline phosphatase; Belongs to the alkaline phosphatase family. (551 aa)
CTC_00671Riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (380 aa)
CTC_00672Riboflavin synthase alpha chain. (216 aa)
ribARiboflavin biosynthesis protein ribA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (402 aa)
ribHRiboflavin synthase beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa)
nadENH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (639 aa)
CTC_00699Pyrazinamidase; Nicotinamidase. (191 aa)
birAPutative transcriptional repressor of the biotin operon birA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (327 aa)
CTC_00983Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (493 aa)
CTC_01205poly(A) polymerase; tRNA nucleotidyltransferase. (451 aa)
yicCyicC protein. (295 aa)
CTC_01217Phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (397 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (744 aa)
defPolypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (150 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (310 aa)
CTC_01221Conserved protein. (226 aa)
CTC_0122216S rRNA M(5)C 967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (454 aa)
rlmNFlorfenicol resistance protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (349 aa)
CTC_01224Phosphoprotein phosphatase 2C. (269 aa)
CTC_01225Serine/threonine protein kinase. (619 aa)
rsgAGTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (290 aa)
CTC_01228Thiamin pyrophosphokinase. (213 aa)
CTC_01284Taurine-binding periplasmic protein precursor. (149 aa)
ftsKPutative stage III sporulation protein E; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Belongs to the FtsK/SpoIIIE/SftA family. (743 aa)
rimOFe-S oxidoreductase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (444 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (274 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa)
greA-2Transcription elongation factor greA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (154 aa)
Your Current Organism:
Clostridium tetani
NCBI taxonomy Id: 212717
Other names: C. tetani E88, Clostridium tetani E88, Clostridium tetani str. E88
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