STRINGSTRING
MED10 MED10 MED18 MED18 PV10_07891 PV10_07891 PV10_05871 PV10_05871 PV10_06482 PV10_06482 PV10_03730 PV10_03730 MED17 MED17 MED4 MED4 PV10_01121 PV10_01121 PV10_01699 PV10_01699 PV10_07653 PV10_07653 PV10_05897 PV10_05897 PV10_05972 PV10_05972 B0A52_02609 B0A52_02609 PV10_04433 PV10_04433 PV10_01985 PV10_01985 PV10_02808 PV10_02808 PV10_03603 PV10_03603 PV10_00388 PV10_00388 PV10_06920 PV10_06920 B0A52_01817 B0A52_01817 PV10_08543 PV10_08543 PV10_08919 PV10_08919 PV10_08930 PV10_08930 PV10_06838 PV10_06838 MED6 MED6 PV10_06724 PV10_06724 PV10_06375 PV10_06375 PV10_04003 PV10_04003 PV10_06736 PV10_06736 PV10_04282 PV10_04282 PV10_03751 PV10_03751 PV10_04759 PV10_04759 PV10_04035 PV10_04035 PV10_04961 PV10_04961 PV10_05091 PV10_05091 PV10_02098 PV10_02098 PV10_02711 PV10_02711 PV10_03006 PV10_03006 PV10_03478 PV10_03478 PV10_03205 PV10_03205 PV10_03420 PV10_03420 PV10_00436 PV10_00436 PV10_01662 PV10_01662 PV10_01196 PV10_01196 PV10_07760 PV10_07760 PV10_06374 PV10_06374 PV10_04069 PV10_04069 PV10_05032 PV10_05032 PV10_02041 PV10_02041 B0A52_07467 B0A52_07467 PV10_00205 PV10_00205 PV10_00376 PV10_00376 B0A52_06028 B0A52_06028 PV10_01598 PV10_01598
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED10Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (425 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (286 aa)
PV10_07891Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1164 aa)
PV10_05871Uncharacterized protein. (215 aa)
PV10_06482HTH TFE/IIEalpha-type domain-containing protein. (487 aa)
PV10_03730Uncharacterized protein. (267 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (628 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (343 aa)
PV10_01121Uncharacterized protein. (373 aa)
PV10_01699Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (175 aa)
PV10_07653Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
PV10_05897CYCLIN domain-containing protein; Belongs to the cyclin family. (403 aa)
PV10_05972Uncharacterized protein. (283 aa)
B0A52_02609S1 domain-containing protein. (169 aa)
PV10_04433DUF3591 domain-containing protein. (1125 aa)
PV10_01985Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (1083 aa)
PV10_02808Uncharacterized protein. (144 aa)
PV10_03603DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1262 aa)
PV10_00388Uncharacterized protein. (78 aa)
PV10_06920Uncharacterized protein. (1309 aa)
B0A52_01817RPOL4c domain-containing protein. (152 aa)
PV10_08543Uncharacterized protein. (386 aa)
PV10_08919Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (128 aa)
PV10_08930Uncharacterized protein. (159 aa)
PV10_06838TFIID_20kDa domain-containing protein. (599 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (323 aa)
PV10_06724DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (130 aa)
PV10_06375TAFII55_N domain-containing protein. (747 aa)
PV10_04003TAF domain-containing protein. (447 aa)
PV10_06736Uncharacterized protein. (846 aa)
PV10_04282TAFII28 domain-containing protein. (348 aa)
PV10_03751Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (112 aa)
PV10_04759DUF4211 domain-containing protein. (650 aa)
PV10_04035General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (463 aa)
PV10_04961RPOLD domain-containing protein. (337 aa)
PV10_05091Uncharacterized protein. (448 aa)
PV10_02098RING-type domain-containing protein. (269 aa)
PV10_02711DNA repair helicase rad15. (818 aa)
PV10_03006RNA_pol_L_2 domain-containing protein. (122 aa)
PV10_03478DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1761 aa)
PV10_03205Acyl_transf_3 domain-containing protein. (466 aa)
PV10_03420Nitroreductase domain-containing protein. (271 aa)
PV10_00436RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (508 aa)
PV10_01662Uncharacterized protein. (634 aa)
PV10_01196Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (705 aa)
PV10_07760F-box domain-containing protein. (553 aa)
PV10_06374BTP domain-containing protein. (236 aa)
PV10_04069Uncharacterized protein. (776 aa)
PV10_05032Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (239 aa)
PV10_02041Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
B0A52_07467TFIIB-type domain-containing protein. (361 aa)
PV10_00205TAF8_C domain-containing protein. (323 aa)
PV10_00376Helicase ATP-binding domain-containing protein. (854 aa)
B0A52_06028TATA-box-binding protein, variant. (257 aa)
PV10_01598TFIIE beta domain-containing protein. (233 aa)
Your Current Organism:
Exophiala mesophila
NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila
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