(15 nodes) RNA polymerase II complex binding, and FACT complex network (Exophiala mesophila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_06913	CDC73_C domain-containing protein. (446 aa)
	PV10_05645	CFEM domain-containing protein. (281 aa)
	PV10_00312	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (856 aa)
	PV10_08535	Uncharacterized protein. (487 aa)
	PV10_05811	Uncharacterized protein. (1242 aa)
	PV10_06236	Transcription elongation factor S-II, variant. (306 aa)
	PV10_03929	Uncharacterized protein. (1026 aa)
	PV10_02580	Uncharacterized protein. (621 aa)
	PV10_03372	Uncharacterized protein. (973 aa)
	PV10_00274	Plus3 domain-containing protein. (606 aa)
	PV10_01878	CFEM domain-containing protein. (476 aa)
	PV10_06358	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (568 aa)
	PV10_00654	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1427 aa)
	PV10_07024	Uncharacterized protein. (556 aa)
	PV10_06700	TFIIS N-terminal domain-containing protein. (401 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV10_00274	PV10_00654	A0A0D1Y6N2	A0A0D1ZQE5	Plus3 domain-containing protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.958
PV10_00274	PV10_01878	A0A0D1Y6N2	A0A0D1YBY8	Plus3 domain-containing protein.	CFEM domain-containing protein.	0.636
PV10_00274	PV10_02580	A0A0D1Y6N2	A0A0D1Y2N7	Plus3 domain-containing protein.	Uncharacterized protein.	0.956
PV10_00274	PV10_03372	A0A0D1Y6N2	A0A0D1Y4Z9	Plus3 domain-containing protein.	Uncharacterized protein.	0.829
PV10_00274	PV10_03929	A0A0D1Y6N2	A0A0D1XWQ7	Plus3 domain-containing protein.	Uncharacterized protein.	0.973
PV10_00274	PV10_05645	A0A0D1Y6N2	A0A0D1WPV6	Plus3 domain-containing protein.	CFEM domain-containing protein.	0.829
PV10_00274	PV10_05811	A0A0D1Y6N2	A0A0D1XSY4	Plus3 domain-containing protein.	Uncharacterized protein.	0.996
PV10_00274	PV10_06236	A0A0D1Y6N2	A0A0D1XU54	Plus3 domain-containing protein.	Transcription elongation factor S-II, variant.	0.850
PV10_00274	PV10_06358	A0A0D1Y6N2	A0A0D1ZB07	Plus3 domain-containing protein.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.989
PV10_00274	PV10_06700	A0A0D1Y6N2	A0A0D1ZZH2	Plus3 domain-containing protein.	TFIIS N-terminal domain-containing protein.	0.849
PV10_00274	PV10_06913	A0A0D1Y6N2	A0A0D1WKQ9	Plus3 domain-containing protein.	CDC73_C domain-containing protein.	0.995
PV10_00274	PV10_07024	A0A0D1Y6N2	A0A0D1ZS80	Plus3 domain-containing protein.	Uncharacterized protein.	0.996
PV10_00274	PV10_08535	A0A0D1Y6N2	A0A0D1XL37	Plus3 domain-containing protein.	Uncharacterized protein.	0.999
PV10_00312	PV10_00654	A0A0D1X3N9	A0A0D1ZQE5	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.982
PV10_00312	PV10_01878	A0A0D1X3N9	A0A0D1YBY8	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	CFEM domain-containing protein.	0.867
PV10_00312	PV10_03372	A0A0D1X3N9	A0A0D1Y4Z9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.773
PV10_00312	PV10_03929	A0A0D1X3N9	A0A0D1XWQ7	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.732
PV10_00312	PV10_05645	A0A0D1X3N9	A0A0D1WPV6	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	CFEM domain-containing protein.	0.773
PV10_00312	PV10_06236	A0A0D1X3N9	A0A0D1XU54	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Transcription elongation factor S-II, variant.	0.987
PV10_00312	PV10_06358	A0A0D1X3N9	A0A0D1ZB07	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.681