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PV10_08081 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa) | ||||
PV10_08211 | Sld5 domain-containing protein. (236 aa) | ||||
PV10_08468 | Uncharacterized protein. (863 aa) | ||||
PV10_08517 | BRCT domain-containing protein. (714 aa) | ||||
PV10_08751 | Uncharacterized protein. (945 aa) | ||||
PV10_07026 | Zn(2)-C6 fungal-type domain-containing protein. (792 aa) | ||||
PV10_07055 | Zn(2)-C6 fungal-type domain-containing protein. (656 aa) | ||||
PV10_07274 | Uncharacterized protein. (1195 aa) | ||||
PV10_07405 | Zn(2)-C6 fungal-type domain-containing protein. (691 aa) | ||||
PV10_07876 | Uncharacterized protein. (884 aa) | ||||
PV10_05603 | Checkpoint protein; Belongs to the HUS1 family. (351 aa) | ||||
PV10_03869 | SAE2 domain-containing protein. (562 aa) | ||||
PV10_04329 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (249 aa) | ||||
PV10_04496 | DNA repair protein rad18. (538 aa) | ||||
PV10_04663 | DNA ligase. (1035 aa) | ||||
PV10_04833 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (750 aa) | ||||
PV10_04946 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (758 aa) | ||||
PV10_05011 | DNA_mis_repair domain-containing protein. (740 aa) | ||||
PV10_05073 | Protein kinase domain-containing protein. (755 aa) | ||||
PV10_02119 | Uncharacterized protein. (1418 aa) | ||||
MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (808 aa) | ||||
PV10_02320 | Uncharacterized protein. (206 aa) | ||||
PV10_02782 | MutL_C domain-containing protein. (876 aa) | ||||
PV10_02985 | Uncharacterized protein. (642 aa) | ||||
PV10_03088 | AP_endonuc_2 domain-containing protein. (534 aa) | ||||
PV10_03105 | DNA ligase. (855 aa) | ||||
PV10_03455 | AAA_23 domain-containing protein. (1306 aa) | ||||
PV10_00207 | Rad51 domain-containing protein. (403 aa) | ||||
PV10_00523 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (530 aa) | ||||
PV10_00822 | Uncharacterized protein. (1249 aa) | ||||
PV10_01307 | Vezatin domain-containing protein. (585 aa) | ||||
PV10_01595 | Sld5 domain-containing protein. (182 aa) | ||||
PV10_01795 | AAA domain-containing protein. (1015 aa) | ||||
PV10_01903 | Uncharacterized protein. (1026 aa) | ||||
PV10_09193 | BRCT domain-containing protein. (497 aa) | ||||
PV10_08066 | Polynucleotide kinase 3'-phosphatase. (455 aa) | ||||
PV10_08522 | SLD3 domain-containing protein. (975 aa) | ||||
PV10_08562 | Uncharacterized protein. (1692 aa) | ||||
B0A52_04315 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (350 aa) | ||||
PV10_08932 | Endo/exonuclease/phosphatase domain-containing protein. (384 aa) | ||||
PV10_07012 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (452 aa) | ||||
PV10_07087 | DNA polymerase. (1453 aa) | ||||
PV10_07396 | AAA domain-containing protein. (397 aa) | ||||
PV10_07753 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (507 aa) | ||||
PV10_07867 | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (693 aa) | ||||
PV10_05490 | UmuC domain-containing protein. (652 aa) | ||||
PV10_05646 | Replication factor C subunit 4. (352 aa) | ||||
PV10_05994 | Protein kinase domain-containing protein. (531 aa) | ||||
PV10_06413 | DNA repair protein. (364 aa) | ||||
PV10_06478 | DBF4-type domain-containing protein. (656 aa) | ||||
PV10_06500 | Uncharacterized protein. (1037 aa) | ||||
PV10_06521 | Uncharacterized protein. (1608 aa) | ||||
PV10_06591 | BRCT domain-containing protein. (1393 aa) | ||||
PV10_03688 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (681 aa) | ||||
PV10_04096 | Uncharacterized protein. (583 aa) | ||||
PV10_04251 | DNA helicase; Belongs to the MCM family. (724 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa) | ||||
B0A52_06663 | Uncharacterized protein. (77 aa) | ||||
PV10_00164 | DNA mismatch repair protein msh-2; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) | ||||
PV10_00345 | Uncharacterized protein. (520 aa) | ||||
PV10_00667 | MRC1 domain-containing protein. (1394 aa) | ||||
NTH1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (437 aa) | ||||
PV10_01113 | DNA ligase. (870 aa) | ||||
PV10_01241 | Exodeoxyribonuclease III. (613 aa) | ||||
PV10_01681 | DNA helicase; Belongs to the MCM family. (863 aa) | ||||
PV10_09167 | RECA_2 domain-containing protein. (481 aa) | ||||
PV10_08108 | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa) | ||||
PV10_08813 | Uncharacterized protein. (1012 aa) | ||||
PV10_08240 | Formamidopyrimidine-DNA glycosylase. (448 aa) | ||||
PV10_06957 | Uncharacterized protein. (1110 aa) | ||||
PV10_08424 | Zn(2)-C6 fungal-type domain-containing protein. (916 aa) | ||||
PV10_07047 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (245 aa) | ||||
PV10_08487 | Uncharacterized protein. (377 aa) | ||||
PV10_07414 | Uncharacterized protein. (1203 aa) | ||||
PV10_08755 | Uncharacterized protein. (548 aa) | ||||
PV10_07468 | Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (418 aa) | ||||
PV10_06954 | Uncharacterized protein. (638 aa) | ||||
PV10_05473 | ERCC4 domain-containing protein. (948 aa) | ||||
PV10_07520 | ENDO3c domain-containing protein. (419 aa) | ||||
PV10_07563 | ORC_WH_C domain-containing protein. (761 aa) | ||||
PV10_07827 | Fungal_trans domain-containing protein. (705 aa) | ||||
UNG1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (434 aa) | ||||
PV10_05296 | Zn(2)-C6 fungal-type domain-containing protein. (521 aa) | ||||
PV10_06387 | DNA_pol_E_B domain-containing protein. (856 aa) | ||||
PV10_06587 | AAA domain-containing protein. (406 aa) | ||||
PV10_06426 | Uncharacterized protein. (1041 aa) | ||||
PV10_06514 | DNA helicase; Belongs to the MCM family. (1004 aa) | ||||
PV10_04471 | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2922 aa) | ||||
PV10_03741 | Stn1 domain-containing protein. (360 aa) | ||||
PV10_03795 | ERCC4 domain-containing protein. (651 aa) | ||||
PV10_04808 | Uncharacterized protein. (628 aa) | ||||
PV10_04813 | DNA polymerase. (1107 aa) | ||||
PV10_04843 | Uncharacterized protein. (492 aa) | ||||
PV10_04133 | Uncharacterized protein. (1099 aa) | ||||
PV10_04194 | Uncharacterized protein. (886 aa) | ||||
PV10_04309 | DNA_LIGASE_A3 domain-containing protein. (1122 aa) | ||||
PV10_05180 | AAA domain-containing protein. (1122 aa) | ||||
PV10_04734 | Uncharacterized protein. (216 aa) | ||||
PV10_02145 | Uncharacterized protein. (1007 aa) | ||||
PV10_02293 | Uncharacterized protein. (688 aa) | ||||
PV10_02437 | Uncharacterized protein. (1343 aa) | ||||
PV10_02216 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1221 aa) | ||||
PV10_02922 | Zf-primase domain-containing protein. (781 aa) | ||||
PV10_02403 | UmuC domain-containing protein. (723 aa) | ||||
PV10_03252 | DNA_mis_repair domain-containing protein. (909 aa) | ||||
PV10_03373 | UDG domain-containing protein. (345 aa) | ||||
PV10_02860 | Uncharacterized protein. (746 aa) | ||||
PV10_02984 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1098 aa) | ||||
PV10_03624 | Uncharacterized protein. (363 aa) | ||||
PV10_03156 | H15 domain-containing protein. (233 aa) | ||||
PV10_00213 | Uncharacterized protein. (747 aa) | ||||
PV10_00296 | HET domain-containing protein. (610 aa) | ||||
PV10_00324 | Protein kinase domain-containing protein. (573 aa) | ||||
PV10_06819 | RECA_2 domain-containing protein. (564 aa) | ||||
PV10_07084 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2242 aa) | ||||
PV10_01213 | VIT domain-containing protein. (368 aa) | ||||
PV10_00679 | Uncharacterized protein. (659 aa) | ||||
PV10_01305 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (267 aa) | ||||
PV10_00814 | ERCC4 domain-containing protein. (612 aa) | ||||
PV10_01504 | Uncharacterized protein. (153 aa) | ||||
PV10_07363 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (1006 aa) | ||||
PV10_07469 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2306 aa) | ||||
PV10_07844 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa) | ||||
PV10_01469 | DNA helicase; Belongs to the MCM family. (915 aa) | ||||
PV10_01567 | DNA polymerase. (1698 aa) | ||||
PV10_05344 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (513 aa) | ||||
PV10_01834 | UmuC domain-containing protein. (603 aa) | ||||
PV10_05818 | Poly [ADP-ribose] polymerase. (702 aa) | ||||
PV10_05932 | DNA helicase; Belongs to the MCM family. (963 aa) | ||||
PV10_06044 | Uncharacterized protein. (560 aa) | ||||
PV10_06154 | SAP domain-containing protein. (684 aa) | ||||
PV10_06691 | TP6A_N domain-containing protein. (370 aa) | ||||
PV10_03975 | WD_REPEATS_REGION domain-containing protein. (864 aa) | ||||
PV10_04153 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1162 aa) | ||||
PV10_04167 | Uncharacterized protein. (277 aa) | ||||
PV10_04448 | Uncharacterized protein. (1153 aa) | ||||
PV10_04479 | zf-C2HE domain-containing protein. (273 aa) | ||||
PV10_04499 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (654 aa) | ||||
PV10_02294 | Uncharacterized protein. (504 aa) | ||||
PV10_02466 | Cell division control protein; Belongs to the CDC6/cdc18 family. (624 aa) | ||||
PV10_02657 | Uncharacterized protein. (791 aa) | ||||
PV10_00133 | Uncharacterized protein. (804 aa) | ||||
PV10_00249 | DUF1767 domain-containing protein. (290 aa) | ||||
PV10_00894 | Replication factor C subunit 5. (597 aa) | ||||
PV10_01095 | Uncharacterized protein. (863 aa) | ||||
PV10_01214 | Uncharacterized protein. (576 aa) | ||||
PV10_01372 | CBFD_NFYB_HMF domain-containing protein. (349 aa) | ||||
PV10_01431 | Replication factor C subunit 1. (1078 aa) |