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PV10_08081 PV10_08081 PV10_08211 PV10_08211 PV10_08468 PV10_08468 PV10_08517 PV10_08517 PV10_08751 PV10_08751 PV10_07026 PV10_07026 PV10_07055 PV10_07055 PV10_07274 PV10_07274 PV10_07405 PV10_07405 PV10_07876 PV10_07876 PV10_05603 PV10_05603 PV10_03869 PV10_03869 PV10_04329 PV10_04329 PV10_04496 PV10_04496 PV10_04663 PV10_04663 PV10_04833 PV10_04833 PV10_04946 PV10_04946 PV10_05011 PV10_05011 PV10_05073 PV10_05073 PV10_02119 PV10_02119 MCM7 MCM7 PV10_02320 PV10_02320 PV10_02782 PV10_02782 PV10_02985 PV10_02985 PV10_03088 PV10_03088 PV10_03105 PV10_03105 PV10_03455 PV10_03455 PV10_00207 PV10_00207 PV10_00523 PV10_00523 PV10_00822 PV10_00822 PV10_01307 PV10_01307 PV10_01595 PV10_01595 PV10_01795 PV10_01795 PV10_01903 PV10_01903 PV10_09193 PV10_09193 PV10_08066 PV10_08066 PV10_08522 PV10_08522 PV10_08562 PV10_08562 B0A52_04315 B0A52_04315 PV10_08932 PV10_08932 PV10_07012 PV10_07012 PV10_07087 PV10_07087 PV10_07396 PV10_07396 PV10_07753 PV10_07753 PV10_07867 PV10_07867 PV10_05490 PV10_05490 PV10_05646 PV10_05646 PV10_05994 PV10_05994 PV10_06413 PV10_06413 PV10_06478 PV10_06478 PV10_06500 PV10_06500 PV10_06521 PV10_06521 PV10_06591 PV10_06591 PV10_03688 PV10_03688 PV10_04096 PV10_04096 PV10_04251 PV10_04251 FEN1 FEN1 B0A52_06663 B0A52_06663 PV10_00164 PV10_00164 PV10_00345 PV10_00345 PV10_00667 PV10_00667 NTH1 NTH1 PV10_01113 PV10_01113 PV10_01241 PV10_01241 PV10_01681 PV10_01681 PV10_09167 PV10_09167 PV10_08108 PV10_08108 PV10_08813 PV10_08813 PV10_08240 PV10_08240 PV10_06957 PV10_06957 PV10_08424 PV10_08424 PV10_07047 PV10_07047 PV10_08487 PV10_08487 PV10_07414 PV10_07414 PV10_08755 PV10_08755 PV10_07468 PV10_07468 PV10_06954 PV10_06954 PV10_05473 PV10_05473 PV10_07520 PV10_07520 PV10_07563 PV10_07563 PV10_07827 PV10_07827 UNG1 UNG1 PV10_05296 PV10_05296 PV10_06387 PV10_06387 PV10_06587 PV10_06587 PV10_06426 PV10_06426 PV10_06514 PV10_06514 PV10_04471 PV10_04471 PV10_03741 PV10_03741 PV10_03795 PV10_03795 PV10_04808 PV10_04808 PV10_04813 PV10_04813 PV10_04843 PV10_04843 PV10_04133 PV10_04133 PV10_04194 PV10_04194 PV10_04309 PV10_04309 PV10_05180 PV10_05180 PV10_04734 PV10_04734 PV10_02145 PV10_02145 PV10_02293 PV10_02293 PV10_02437 PV10_02437 PV10_02216 PV10_02216 PV10_02922 PV10_02922 PV10_02403 PV10_02403 PV10_03252 PV10_03252 PV10_03373 PV10_03373 PV10_02860 PV10_02860 PV10_02984 PV10_02984 PV10_03624 PV10_03624 PV10_03156 PV10_03156 PV10_00213 PV10_00213 PV10_00296 PV10_00296 PV10_00324 PV10_00324 PV10_06819 PV10_06819 PV10_07084 PV10_07084 PV10_01213 PV10_01213 PV10_00679 PV10_00679 PV10_01305 PV10_01305 PV10_00814 PV10_00814 PV10_01504 PV10_01504 PV10_07363 PV10_07363 PV10_07469 PV10_07469 PV10_07844 PV10_07844 PV10_01469 PV10_01469 PV10_01567 PV10_01567 PV10_05344 PV10_05344 PV10_01834 PV10_01834 PV10_05818 PV10_05818 PV10_05932 PV10_05932 PV10_06044 PV10_06044 PV10_06154 PV10_06154 PV10_06691 PV10_06691 PV10_03975 PV10_03975 PV10_04153 PV10_04153 PV10_04167 PV10_04167 PV10_04448 PV10_04448 PV10_04479 PV10_04479 PV10_04499 PV10_04499 PV10_02294 PV10_02294 PV10_02466 PV10_02466 PV10_02657 PV10_02657 PV10_00133 PV10_00133 PV10_00249 PV10_00249 PV10_00894 PV10_00894 PV10_01095 PV10_01095 PV10_01214 PV10_01214 PV10_01372 PV10_01372 PV10_01431 PV10_01431
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PV10_08081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
PV10_08211Sld5 domain-containing protein. (236 aa)
PV10_08468Uncharacterized protein. (863 aa)
PV10_08517BRCT domain-containing protein. (714 aa)
PV10_08751Uncharacterized protein. (945 aa)
PV10_07026Zn(2)-C6 fungal-type domain-containing protein. (792 aa)
PV10_07055Zn(2)-C6 fungal-type domain-containing protein. (656 aa)
PV10_07274Uncharacterized protein. (1195 aa)
PV10_07405Zn(2)-C6 fungal-type domain-containing protein. (691 aa)
PV10_07876Uncharacterized protein. (884 aa)
PV10_05603Checkpoint protein; Belongs to the HUS1 family. (351 aa)
PV10_03869SAE2 domain-containing protein. (562 aa)
PV10_04329DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (249 aa)
PV10_04496DNA repair protein rad18. (538 aa)
PV10_04663DNA ligase. (1035 aa)
PV10_04833Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (750 aa)
PV10_04946Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (758 aa)
PV10_05011DNA_mis_repair domain-containing protein. (740 aa)
PV10_05073Protein kinase domain-containing protein. (755 aa)
PV10_02119Uncharacterized protein. (1418 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (808 aa)
PV10_02320Uncharacterized protein. (206 aa)
PV10_02782MutL_C domain-containing protein. (876 aa)
PV10_02985Uncharacterized protein. (642 aa)
PV10_03088AP_endonuc_2 domain-containing protein. (534 aa)
PV10_03105DNA ligase. (855 aa)
PV10_03455AAA_23 domain-containing protein. (1306 aa)
PV10_00207Rad51 domain-containing protein. (403 aa)
PV10_00523DNA primase; Belongs to the eukaryotic-type primase small subunit family. (530 aa)
PV10_00822Uncharacterized protein. (1249 aa)
PV10_01307Vezatin domain-containing protein. (585 aa)
PV10_01595Sld5 domain-containing protein. (182 aa)
PV10_01795AAA domain-containing protein. (1015 aa)
PV10_01903Uncharacterized protein. (1026 aa)
PV10_09193BRCT domain-containing protein. (497 aa)
PV10_08066Polynucleotide kinase 3'-phosphatase. (455 aa)
PV10_08522SLD3 domain-containing protein. (975 aa)
PV10_08562Uncharacterized protein. (1692 aa)
B0A52_04315DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (350 aa)
PV10_08932Endo/exonuclease/phosphatase domain-containing protein. (384 aa)
PV10_07012DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (452 aa)
PV10_07087DNA polymerase. (1453 aa)
PV10_07396AAA domain-containing protein. (397 aa)
PV10_07753DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (507 aa)
PV10_07867DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (693 aa)
PV10_05490UmuC domain-containing protein. (652 aa)
PV10_05646Replication factor C subunit 4. (352 aa)
PV10_05994Protein kinase domain-containing protein. (531 aa)
PV10_06413DNA repair protein. (364 aa)
PV10_06478DBF4-type domain-containing protein. (656 aa)
PV10_06500Uncharacterized protein. (1037 aa)
PV10_06521Uncharacterized protein. (1608 aa)
PV10_06591BRCT domain-containing protein. (1393 aa)
PV10_03688DNA_MISMATCH_REPAIR_2 domain-containing protein. (681 aa)
PV10_04096Uncharacterized protein. (583 aa)
PV10_04251DNA helicase; Belongs to the MCM family. (724 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
B0A52_06663Uncharacterized protein. (77 aa)
PV10_00164DNA mismatch repair protein msh-2; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
PV10_00345Uncharacterized protein. (520 aa)
PV10_00667MRC1 domain-containing protein. (1394 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (437 aa)
PV10_01113DNA ligase. (870 aa)
PV10_01241Exodeoxyribonuclease III. (613 aa)
PV10_01681DNA helicase; Belongs to the MCM family. (863 aa)
PV10_09167RECA_2 domain-containing protein. (481 aa)
PV10_08108ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
PV10_08813Uncharacterized protein. (1012 aa)
PV10_08240Formamidopyrimidine-DNA glycosylase. (448 aa)
PV10_06957Uncharacterized protein. (1110 aa)
PV10_08424Zn(2)-C6 fungal-type domain-containing protein. (916 aa)
PV10_07047DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (245 aa)
PV10_08487Uncharacterized protein. (377 aa)
PV10_07414Uncharacterized protein. (1203 aa)
PV10_08755Uncharacterized protein. (548 aa)
PV10_07468Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (418 aa)
PV10_06954Uncharacterized protein. (638 aa)
PV10_05473ERCC4 domain-containing protein. (948 aa)
PV10_07520ENDO3c domain-containing protein. (419 aa)
PV10_07563ORC_WH_C domain-containing protein. (761 aa)
PV10_07827Fungal_trans domain-containing protein. (705 aa)
UNG1Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (434 aa)
PV10_05296Zn(2)-C6 fungal-type domain-containing protein. (521 aa)
PV10_06387DNA_pol_E_B domain-containing protein. (856 aa)
PV10_06587AAA domain-containing protein. (406 aa)
PV10_06426Uncharacterized protein. (1041 aa)
PV10_06514DNA helicase; Belongs to the MCM family. (1004 aa)
PV10_04471Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2922 aa)
PV10_03741Stn1 domain-containing protein. (360 aa)
PV10_03795ERCC4 domain-containing protein. (651 aa)
PV10_04808Uncharacterized protein. (628 aa)
PV10_04813DNA polymerase. (1107 aa)
PV10_04843Uncharacterized protein. (492 aa)
PV10_04133Uncharacterized protein. (1099 aa)
PV10_04194Uncharacterized protein. (886 aa)
PV10_04309DNA_LIGASE_A3 domain-containing protein. (1122 aa)
PV10_05180AAA domain-containing protein. (1122 aa)
PV10_04734Uncharacterized protein. (216 aa)
PV10_02145Uncharacterized protein. (1007 aa)
PV10_02293Uncharacterized protein. (688 aa)
PV10_02437Uncharacterized protein. (1343 aa)
PV10_02216DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1221 aa)
PV10_02922Zf-primase domain-containing protein. (781 aa)
PV10_02403UmuC domain-containing protein. (723 aa)
PV10_03252DNA_mis_repair domain-containing protein. (909 aa)
PV10_03373UDG domain-containing protein. (345 aa)
PV10_02860Uncharacterized protein. (746 aa)
PV10_02984DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1098 aa)
PV10_03624Uncharacterized protein. (363 aa)
PV10_03156H15 domain-containing protein. (233 aa)
PV10_00213Uncharacterized protein. (747 aa)
PV10_00296HET domain-containing protein. (610 aa)
PV10_00324Protein kinase domain-containing protein. (573 aa)
PV10_06819RECA_2 domain-containing protein. (564 aa)
PV10_07084DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2242 aa)
PV10_01213VIT domain-containing protein. (368 aa)
PV10_00679Uncharacterized protein. (659 aa)
PV10_01305Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (267 aa)
PV10_00814ERCC4 domain-containing protein. (612 aa)
PV10_01504Uncharacterized protein. (153 aa)
PV10_07363DNA_MISMATCH_REPAIR_2 domain-containing protein. (1006 aa)
PV10_07469Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2306 aa)
PV10_07844Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa)
PV10_01469DNA helicase; Belongs to the MCM family. (915 aa)
PV10_01567DNA polymerase. (1698 aa)
PV10_05344ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (513 aa)
PV10_01834UmuC domain-containing protein. (603 aa)
PV10_05818Poly [ADP-ribose] polymerase. (702 aa)
PV10_05932DNA helicase; Belongs to the MCM family. (963 aa)
PV10_06044Uncharacterized protein. (560 aa)
PV10_06154SAP domain-containing protein. (684 aa)
PV10_06691TP6A_N domain-containing protein. (370 aa)
PV10_03975WD_REPEATS_REGION domain-containing protein. (864 aa)
PV10_04153DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1162 aa)
PV10_04167Uncharacterized protein. (277 aa)
PV10_04448Uncharacterized protein. (1153 aa)
PV10_04479zf-C2HE domain-containing protein. (273 aa)
PV10_04499DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (654 aa)
PV10_02294Uncharacterized protein. (504 aa)
PV10_02466Cell division control protein; Belongs to the CDC6/cdc18 family. (624 aa)
PV10_02657Uncharacterized protein. (791 aa)
PV10_00133Uncharacterized protein. (804 aa)
PV10_00249DUF1767 domain-containing protein. (290 aa)
PV10_00894Replication factor C subunit 5. (597 aa)
PV10_01095Uncharacterized protein. (863 aa)
PV10_01214Uncharacterized protein. (576 aa)
PV10_01372CBFD_NFYB_HMF domain-containing protein. (349 aa)
PV10_01431Replication factor C subunit 1. (1078 aa)
Your Current Organism:
Exophiala mesophila
NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila
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