(23 nodes) HDR through Homologous Recombination (HRR), and 3-5 DNA helicase activity network (Exophiala mesophila)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	PV10_08081	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
	PV10_08468	Uncharacterized protein. (863 aa)
	PV10_03869	SAE2 domain-containing protein. (562 aa)
	PV10_04946	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (758 aa)
	PV10_03455	AAA_23 domain-containing protein. (1306 aa)
	PV10_00207	Rad51 domain-containing protein. (403 aa)
	PV10_08562	Uncharacterized protein. (1692 aa)
	B0A52_04315	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (350 aa)
	PV10_06521	Uncharacterized protein. (1608 aa)
	PV10_09167	RECA_2 domain-containing protein. (481 aa)
	PV10_08755	Uncharacterized protein. (548 aa)
	PV10_03795	ERCC4 domain-containing protein. (651 aa)
	PV10_04133	Uncharacterized protein. (1099 aa)
	PV10_05180	AAA domain-containing protein. (1122 aa)
	PV10_02145	Uncharacterized protein. (1007 aa)
	PV10_02860	Uncharacterized protein. (746 aa)
	PV10_00213	Uncharacterized protein. (747 aa)
	PV10_06819	RECA_2 domain-containing protein. (564 aa)
	PV10_00814	ERCC4 domain-containing protein. (612 aa)
	PV10_07844	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa)
	PV10_05344	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (513 aa)
	PV10_04167	Uncharacterized protein. (277 aa)
	PV10_00249	DUF1767 domain-containing protein. (290 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_04315	PV10_00207	A0A0D1XLL8	A0A0D1X3C6	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Rad51 domain-containing protein.	0.925
B0A52_04315	PV10_00213	A0A0D1XLL8	A0A0D1ZNW6	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.986
B0A52_04315	PV10_00249	A0A0D1XLL8	A0A0D2ABR5	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	DUF1767 domain-containing protein.	0.887
B0A52_04315	PV10_00814	A0A0D1XLL8	A0A0D1ZT10	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	ERCC4 domain-containing protein.	0.967
B0A52_04315	PV10_02145	A0A0D1XLL8	A0A0D1ZIE4	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.983
B0A52_04315	PV10_02860	A0A0D1XLL8	A0A0D1ZMH9	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.823
B0A52_04315	PV10_03455	A0A0D1XLL8	A0A0D1X241	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	AAA_23 domain-containing protein.	0.924
B0A52_04315	PV10_03795	A0A0D1XLL8	A0A0D1ZF97	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	ERCC4 domain-containing protein.	0.517
B0A52_04315	PV10_03869	A0A0D1XLL8	A0A0D1WTQ5	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	SAE2 domain-containing protein.	0.822
B0A52_04315	PV10_04133	A0A0D1XLL8	A0A0D1ZGA6	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.811
B0A52_04315	PV10_04167	A0A0D1XLL8	A0A0D2A1J8	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.919
B0A52_04315	PV10_04946	A0A0D1XLL8	A0A0D1WWI1	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.955
B0A52_04315	PV10_05180	A0A0D1XLL8	A0A0D1ZHE5	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	AAA domain-containing protein.	0.928
B0A52_04315	PV10_05344	A0A0D1XLL8	A0A0D1ZV62	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.890
B0A52_04315	PV10_06521	A0A0D1XLL8	A0A0D1XUZ4	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.992
B0A52_04315	PV10_06819	A0A0D1XLL8	A0A0D1ZRL6	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	RECA_2 domain-containing protein.	0.550
B0A52_04315	PV10_07844	A0A0D1XLL8	A0A0D1ZUU4	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.991
B0A52_04315	PV10_08081	A0A0D1XLL8	A0A0D1WHV3	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.928
B0A52_04315	PV10_08468	A0A0D1XLL8	A0A0D1WIX8	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.870
B0A52_04315	PV10_08562	A0A0D1XLL8	A0A0D1XL79	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.889