STRINGSTRING
PV10_07844 PV10_07844 PV10_09120 PV10_09120 PV10_00679 PV10_00679 PV10_00812 PV10_00812 B0A52_01677 B0A52_01677 PV10_06154 PV10_06154 PV10_08081 PV10_08081 PV10_05603 PV10_05603 PV10_04946 PV10_04946 PV10_05034 PV10_05034 PV10_05143 PV10_05143 PV10_03455 PV10_03455 PV10_08562 PV10_08562 B0A52_04315 B0A52_04315 PV10_05410 PV10_05410 PV10_06115 PV10_06115 PV10_06521 PV10_06521 PV10_02087 PV10_02087 PV10_03291 PV10_03291 PV10_09129 PV10_09129 PV10_08108 PV10_08108 PV10_09126 PV10_09126 KAE1 KAE1 PV10_07593 PV10_07593 PV10_07469 PV10_07469 PV10_06340 PV10_06340 PV10_04471 PV10_04471 PV10_05122 PV10_05122 PV10_04426 PV10_04426 PIF1 PIF1 PV10_02214 PV10_02214 PV10_09084 PV10_09084
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PV10_07844Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa)
PV10_09120SnoaL-like domain-containing protein. (139 aa)
PV10_00679Uncharacterized protein. (659 aa)
PV10_00812CUE domain-containing protein. (879 aa)
B0A52_01677Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
PV10_06154SAP domain-containing protein. (684 aa)
PV10_08081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
PV10_05603Checkpoint protein; Belongs to the HUS1 family. (351 aa)
PV10_04946Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (758 aa)
PV10_05034HTH myb-type domain-containing protein. (699 aa)
PV10_05143HTH APSES-type domain-containing protein. (406 aa)
PV10_03455AAA_23 domain-containing protein. (1306 aa)
PV10_08562Uncharacterized protein. (1692 aa)
B0A52_04315DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (350 aa)
PV10_05410Uncharacterized protein. (324 aa)
PV10_06115Uncharacterized protein. (1674 aa)
PV10_06521Uncharacterized protein. (1608 aa)
PV10_02087Rif1_N domain-containing protein. (1482 aa)
PV10_03291DRMBL domain-containing protein. (937 aa)
PV10_09129Uncharacterized protein. (815 aa)
PV10_08108ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
PV10_09126Uncharacterized protein. (500 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (377 aa)
PV10_07593Telomere_reg-2 domain-containing protein. (1078 aa)
PV10_07469Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2306 aa)
PV10_06340Sua5/YciO/YrdC/YwlC family tRNA threonylcarbamoyl adenosine modification protein. (537 aa)
PV10_04471Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2922 aa)
PV10_05122Telo_bind domain-containing protein. (670 aa)
PV10_04426HD domain-containing protein. (232 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (825 aa)
PV10_02214RRN9 domain-containing protein. (740 aa)
PV10_09084HABP4_PAI-RBP1 domain-containing protein. (356 aa)
Your Current Organism:
Exophiala mesophila
NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila
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