(44 nodes) Ubiquitin-dependent ERAD pathway network (Exophiala mesophila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_07150	RING-type domain-containing protein. (887 aa)
	PV10_08409	Uncharacterized protein. (339 aa)
	PV10_06930	Uncharacterized protein. (759 aa)
	PV10_08670	J domain-containing protein. (349 aa)
	PV10_08024	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (605 aa)
	PV10_01527	Uncharacterized protein. (188 aa)
	PV10_00020	OTU domain-containing protein. (343 aa)
	PV10_03507	UBX domain-containing protein. (513 aa)
	PV10_05283	Uncharacterized protein. (250 aa)
	PV10_05175	UBIQUITIN_CONJUGAT_2 domain-containing protein. (425 aa)
	PV10_04226	RING-CH-type domain-containing protein. (1563 aa)
	PV10_03775	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (590 aa)
	PV10_06162	UV excision repair protein Rad23. (398 aa)
	PV10_05939	Protein transporter sec13; Belongs to the WD repeat SEC13 family. (318 aa)
	PV10_07372	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (1070 aa)
	PV10_01937	ATPase_AAA_core domain-containing protein. (470 aa)
	PV10_00153	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (914 aa)
	B0A52_02785	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (393 aa)
	PV10_03996	Uncharacterized protein. (390 aa)
	PV10_03894	Long chronological lifespan protein 2; Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway. (488 aa)
	PV10_03838	Uncharacterized protein. (555 aa)
	B0A52_03437	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family. (476 aa)
	PV10_05820	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (260 aa)
	PV10_07021	UBIQUITIN_CONJUGAT_2 domain-containing protein. (278 aa)
	PV10_09155	Uncharacterized protein. (417 aa)
	PV10_05637	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (255 aa)
	PV10_05817	ANK_REP_REGION domain-containing protein. (640 aa)
	PV10_05898	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (243 aa)
	PV10_06335	Chaperone DnaK; Belongs to the heat shock protein 70 family. (678 aa)
	PV10_06690	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
	PV10_06527	PRKCSH domain-containing protein. (529 aa)
	PV10_05214	UBX domain-containing protein. (574 aa)
	PV10_04820	Uncharacterized protein. (368 aa)
	PV10_02235	Uncharacterized protein. (501 aa)
	PV10_08446	TPR_REGION domain-containing protein. (376 aa)
	PV10_08671	U-box domain-containing protein. (1093 aa)
	PV10_07732	N-acetyltransferase domain-containing protein. (189 aa)
	PV10_01698	HECT domain-containing protein. (1234 aa)
	PV10_05492	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (575 aa)
	PV10_06369	Uncharacterized protein. (417 aa)
	PV10_05190	Cell division control protein 48; Belongs to the AAA ATPase family. (840 aa)
	PV10_02252	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (782 aa)
	PV10_03010	Uncharacterized protein. (1894 aa)
	PV10_01105	Uncharacterized protein. (928 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_02785	PV10_01937	A0A0D1WYY1	A0A0D1X8E4	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	ATPase_AAA_core domain-containing protein.	0.733
B0A52_02785	PV10_03010	A0A0D1WYY1	A0A0D2A8N6	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.888
B0A52_02785	PV10_03996	A0A0D1WYY1	A0A0D1WU15	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.732
B0A52_02785	PV10_05190	A0A0D1WYY1	A0A0D2A4Y1	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	Cell division control protein 48; Belongs to the AAA ATPase family.	0.748
B0A52_02785	PV10_06162	A0A0D1WYY1	A0A0D1XTY3	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	UV excision repair protein Rad23.	0.901
B0A52_02785	PV10_06930	A0A0D1WYY1	A0A0D1Z469	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.706
B0A52_03437	PV10_01105	A0A0D1WR08	A0A0D2AEJ4	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Uncharacterized protein.	0.642
B0A52_03437	PV10_03996	A0A0D1WR08	A0A0D1WU15	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Uncharacterized protein.	0.477
B0A52_03437	PV10_04226	A0A0D1WR08	A0A0D1XXM5	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	RING-CH-type domain-containing protein.	0.617
B0A52_03437	PV10_04820	A0A0D1WR08	A0A0D1ZIA8	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Uncharacterized protein.	0.594
B0A52_03437	PV10_05283	A0A0D1WR08	A0A0D1Y0W0	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Uncharacterized protein.	0.594
B0A52_03437	PV10_05637	A0A0D1WR08	A0A0D1Z8N1	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.623
B0A52_03437	PV10_05820	A0A0D1WR08	A0A0D1WQA5	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.632
B0A52_03437	PV10_05939	A0A0D1WR08	A0A0D1XTC1	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Protein transporter sec13; Belongs to the WD repeat SEC13 family.	0.481
B0A52_03437	PV10_06162	A0A0D1WR08	A0A0D1XTY3	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	UV excision repair protein Rad23.	0.469
B0A52_03437	PV10_06335	A0A0D1WR08	A0A0D1ZAY3	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Chaperone DnaK; Belongs to the heat shock protein 70 family.	0.805
B0A52_03437	PV10_06369	A0A0D1WR08	A0A0D1ZYB9	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	Uncharacterized protein.	0.473
B0A52_03437	PV10_06690	A0A0D1WR08	A0A0D1ZBZ2	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.621
B0A52_03437	PV10_07150	A0A0D1WR08	A0A0D1Z4P6	Protein transport protein SEC61 subunit alpha; Belongs to the SecY/SEC61-alpha family.	RING-type domain-containing protein.	0.594
PV10_00020	PV10_01937	A0A0D1Y626	A0A0D1X8E4	OTU domain-containing protein.	ATPase_AAA_core domain-containing protein.	0.954