(10 nodes) Mitotic DNA damage checkpoint signaling network (Exophiala mesophila)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_00667	MRC1 domain-containing protein. (1394 aa)
	PV10_00814	ERCC4 domain-containing protein. (612 aa)
	PV10_06500	Uncharacterized protein. (1037 aa)
	PV10_03643	Protein kinase domain-containing protein. (527 aa)
	PV10_05603	Checkpoint protein; Belongs to the HUS1 family. (351 aa)
	PV10_04946	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (758 aa)
	PV10_07012	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (452 aa)
	PV10_04194	Uncharacterized protein. (886 aa)
	PV10_03795	ERCC4 domain-containing protein. (651 aa)
	PV10_07723	Uncharacterized protein. (327 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV10_00667	PV10_03643	A0A0D1Y7W6	A0A0D1ZN94	MRC1 domain-containing protein.	Protein kinase domain-containing protein.	0.619
PV10_00667	PV10_04194	A0A0D1Y7W6	A0A0D1ZGJ9	MRC1 domain-containing protein.	Uncharacterized protein.	0.464
PV10_00667	PV10_05603	A0A0D1Y7W6	A0A0D1WPQ8	MRC1 domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.609
PV10_00667	PV10_06500	A0A0D1Y7W6	A0A0D1XUX6	MRC1 domain-containing protein.	Uncharacterized protein.	0.988
PV10_00667	PV10_07012	A0A0D1Y7W6	A0A0D1XND2	MRC1 domain-containing protein.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.766
PV10_00814	PV10_03643	A0A0D1ZT10	A0A0D1ZN94	ERCC4 domain-containing protein.	Protein kinase domain-containing protein.	0.557
PV10_00814	PV10_03795	A0A0D1ZT10	A0A0D1ZF97	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.987
PV10_00814	PV10_04194	A0A0D1ZT10	A0A0D1ZGJ9	ERCC4 domain-containing protein.	Uncharacterized protein.	0.597
PV10_00814	PV10_04946	A0A0D1ZT10	A0A0D1WWI1	ERCC4 domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.837
PV10_00814	PV10_05603	A0A0D1ZT10	A0A0D1WPQ8	ERCC4 domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.576
PV10_00814	PV10_06500	A0A0D1ZT10	A0A0D1XUX6	ERCC4 domain-containing protein.	Uncharacterized protein.	0.804
PV10_00814	PV10_07012	A0A0D1ZT10	A0A0D1XND2	ERCC4 domain-containing protein.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.538
PV10_03643	PV10_00667	A0A0D1ZN94	A0A0D1Y7W6	Protein kinase domain-containing protein.	MRC1 domain-containing protein.	0.619
PV10_03643	PV10_00814	A0A0D1ZN94	A0A0D1ZT10	Protein kinase domain-containing protein.	ERCC4 domain-containing protein.	0.557
PV10_03643	PV10_04194	A0A0D1ZN94	A0A0D1ZGJ9	Protein kinase domain-containing protein.	Uncharacterized protein.	0.880
PV10_03643	PV10_04946	A0A0D1ZN94	A0A0D1WWI1	Protein kinase domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.792
PV10_03643	PV10_05603	A0A0D1ZN94	A0A0D1WPQ8	Protein kinase domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.797
PV10_03643	PV10_06500	A0A0D1ZN94	A0A0D1XUX6	Protein kinase domain-containing protein.	Uncharacterized protein.	0.962
PV10_03643	PV10_07012	A0A0D1ZN94	A0A0D1XND2	Protein kinase domain-containing protein.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.813
PV10_03795	PV10_00814	A0A0D1ZF97	A0A0D1ZT10	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.987