(21 nodes) RNA polymerase II preinitiation complex assembly network (Exophiala mesophila)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_04433	DUF3591 domain-containing protein. (1125 aa)
	PV10_05871	Uncharacterized protein. (215 aa)
	PV10_03730	Uncharacterized protein. (267 aa)
	PV10_03752	Uncharacterized protein. (350 aa)
	PV10_08605	Fungal_trans domain-containing protein. (537 aa)
	B0A52_01899	CBFD_NFYB_HMF domain-containing protein. (163 aa)
	PV10_06236	Transcription elongation factor S-II, variant. (306 aa)
	PV10_00663	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (706 aa)
	PV10_08543	Uncharacterized protein. (386 aa)
	PV10_06838	TFIID_20kDa domain-containing protein. (599 aa)
	PV10_06375	TAFII55_N domain-containing protein. (747 aa)
	PV10_04003	TAF domain-containing protein. (447 aa)
	PV10_04282	TAFII28 domain-containing protein. (348 aa)
	PV10_03751	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (112 aa)
	PV10_03205	Acyl_transf_3 domain-containing protein. (466 aa)
	PV10_03389	CBFD_NFYB_HMF domain-containing protein. (359 aa)
	PV10_01045	Uncharacterized protein. (259 aa)
	PV10_05032	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (239 aa)
	B0A52_07467	TFIIB-type domain-containing protein. (361 aa)
	PV10_00080	Zn(2)-C6 fungal-type domain-containing protein. (615 aa)
	PV10_01046	Zn(2)-C6 fungal-type domain-containing protein. (648 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_01899	B0A52_07467	A0A0D1XQK4	A0A0D2A8F2	CBFD_NFYB_HMF domain-containing protein.	TFIIB-type domain-containing protein.	0.588
B0A52_01899	PV10_03389	A0A0D1XQK4	A0A0D1ZP68	CBFD_NFYB_HMF domain-containing protein.	CBFD_NFYB_HMF domain-containing protein.	0.990
B0A52_07467	B0A52_01899	A0A0D2A8F2	A0A0D1XQK4	TFIIB-type domain-containing protein.	CBFD_NFYB_HMF domain-containing protein.	0.588
B0A52_07467	PV10_00663	A0A0D2A8F2	A0A0D1Y7V8	TFIIB-type domain-containing protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.868
B0A52_07467	PV10_03205	A0A0D2A8F2	A0A0D1ZNP2	TFIIB-type domain-containing protein.	Acyl_transf_3 domain-containing protein.	0.926
B0A52_07467	PV10_03389	A0A0D2A8F2	A0A0D1ZP68	TFIIB-type domain-containing protein.	CBFD_NFYB_HMF domain-containing protein.	0.660
B0A52_07467	PV10_03730	A0A0D2A8F2	A0A0D1WTA1	TFIIB-type domain-containing protein.	Uncharacterized protein.	0.971
B0A52_07467	PV10_03751	A0A0D2A8F2	A0A0D1ZF02	TFIIB-type domain-containing protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.961
B0A52_07467	PV10_03752	A0A0D2A8F2	A0A0D1WTC1	TFIIB-type domain-containing protein.	Uncharacterized protein.	0.954
B0A52_07467	PV10_04003	A0A0D2A8F2	A0A0D1ZDF2	TFIIB-type domain-containing protein.	TAF domain-containing protein.	0.926
B0A52_07467	PV10_04282	A0A0D2A8F2	A0A0D1ZEC8	TFIIB-type domain-containing protein.	TAFII28 domain-containing protein.	0.926
B0A52_07467	PV10_04433	A0A0D2A8F2	A0A0D1XY87	TFIIB-type domain-containing protein.	DUF3591 domain-containing protein.	0.979
B0A52_07467	PV10_05032	A0A0D2A8F2	A0A0D2A4E2	TFIIB-type domain-containing protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.958
B0A52_07467	PV10_05871	A0A0D2A8F2	A0A0D1WQE4	TFIIB-type domain-containing protein.	Uncharacterized protein.	0.897
B0A52_07467	PV10_06236	A0A0D2A8F2	A0A0D1XU54	TFIIB-type domain-containing protein.	Transcription elongation factor S-II, variant.	0.984
B0A52_07467	PV10_06375	A0A0D2A8F2	A0A0D1ZD70	TFIIB-type domain-containing protein.	TAFII55_N domain-containing protein.	0.925
B0A52_07467	PV10_06838	A0A0D2A8F2	A0A0D1Z6C7	TFIIB-type domain-containing protein.	TFIID_20kDa domain-containing protein.	0.947
B0A52_07467	PV10_08543	A0A0D2A8F2	A0A0D1Z4S1	TFIIB-type domain-containing protein.	Uncharacterized protein.	0.995
PV10_00663	B0A52_07467	A0A0D1Y7V8	A0A0D2A8F2	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	TFIIB-type domain-containing protein.	0.868
PV10_00663	PV10_03205	A0A0D1Y7V8	A0A0D1ZNP2	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Acyl_transf_3 domain-containing protein.	0.711