(132 nodes) Cell division network (Exophiala mesophila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_03062	Uncharacterized protein. (161 aa)
	PV10_05143	HTH APSES-type domain-containing protein. (406 aa)
	PV10_01948	CS domain-containing protein. (211 aa)
	PV10_02129	Uncharacterized protein. (844 aa)
	B0A52_02656	Conidiophore development protein hymA. (376 aa)
	PV10_02635	Uncharacterized protein. (768 aa)
	B0A52_09198	Cell division control protein 42. (193 aa)
	PV10_03496	Uncharacterized protein. (1510 aa)
	PV10_03617	RGS domain-containing protein. (380 aa)
	PV10_00086	Ras-GAP domain-containing protein. (1252 aa)
	PV10_00168	C2 domain-containing protein. (935 aa)
	PV10_00377	Uncharacterized protein. (841 aa)
	PV10_00387	Mannan endo-1,6-alpha-mannosidase. (461 aa)
	PV10_01329	CLASP_N domain-containing protein. (960 aa)
	PV10_01605	Spindle pole body component. (920 aa)
	PV10_07968	Uncharacterized protein. (757 aa)
	PV10_07116	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (696 aa)
	PV10_07672	Chitin synthase 1. (1028 aa)
	PV10_05439	Uncharacterized protein. (286 aa)
	PV10_05680	Uncharacterized protein. (97 aa)
	PV10_05740	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1337 aa)
	PV10_06294	Uncharacterized protein. (336 aa)
	B0A52_07382	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (391 aa)
	PV10_06788	ANK_REP_REGION domain-containing protein. (554 aa)
	PV10_05077	Uncharacterized protein. (1749 aa)
	PV10_01387	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (455 aa)
	PV10_01700	Uncharacterized protein. (756 aa)
	PV10_01729	Uncharacterized protein. (1109 aa)
	PV10_01770	ANAPC5 domain-containing protein. (770 aa)
	B0A52_08940	Uncharacterized protein. (297 aa)
	PV10_07097	Uncharacterized protein. (221 aa)
	PV10_08551	Uncharacterized protein. (666 aa)
	PV10_08667	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (339 aa)
	B0A52_01520	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (328 aa)
	PV10_08746	Uncharacterized protein. (200 aa)
	PV10_07588	Calcium/calmodulin-dependent protein kinase; Belongs to the protein kinase superfamily. (417 aa)
	B0A52_00951	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (130 aa)
	B0A52_09478	Myosin regulatory light chain cdc4. (146 aa)
	PV10_07878	PH domain-containing protein. (1387 aa)
	PV10_07119	Peptidase C50 domain-containing protein. (2054 aa)
	PV10_05435	Uncharacterized protein. (857 aa)
	PV10_07553	Serine/threonine-protein kinase pef1; Belongs to the protein kinase superfamily. (412 aa)
	PV10_05724	Uncharacterized protein. (136 aa)
	PV10_07765	Uncharacterized protein. (310 aa)
	PV10_06168	Uncharacterized protein. (346 aa)
	B0A52_06474	Actin, gamma. (375 aa)
	PV10_05800	Non-specific serine/threonine protein kinase. (892 aa)
	PV10_05834	Uncharacterized protein. (660 aa)
	PV10_06744	WD_REPEATS_REGION domain-containing protein. (889 aa)
	PV10_03717	Uncharacterized protein. (940 aa)
	PV10_06261	CULLIN_2 domain-containing protein; Belongs to the cullin family. (776 aa)
	PV10_04058	Mannan endo-1,6-alpha-mannosidase. (464 aa)
	PV10_04063	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa)
	PV10_03922	Uncharacterized protein. (1036 aa)
	PV10_04773	Uncharacterized protein. (863 aa)
	PV10_05041	Uncharacterized protein. (114 aa)
	PV10_02150	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (413 aa)
	PV10_05051	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1156 aa)
	PV10_02771	Uncharacterized protein. (1054 aa)
	PV10_02784	Uncharacterized protein. (1133 aa)
	PV10_02798	Structural maintenance of chromosomes protein. (1205 aa)
	PV10_02443	Uncharacterized protein. (356 aa)
	PV10_02551	Uncharacterized protein. (739 aa)
	PV10_02773	Rhodanese domain-containing protein. (562 aa)
	PV10_03403	Senescence domain-containing protein. (519 aa)
	PV10_03008	Uncharacterized protein. (939 aa)
	PV10_00238	Uncharacterized protein. (219 aa)
	PV10_08166	Protein kinase domain-containing protein. (1479 aa)
	PV10_08450	Uncharacterized protein. (277 aa)
	PV10_08569	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (477 aa)
	PV10_00176	Chitin synthase; Plays a major role in cell wall biogenesis. (924 aa)
	PV10_08923	Uncharacterized protein. (174 aa)
	PV10_01233	Cnd3 domain-containing protein. (828 aa)
	B0A52_01677	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
	PV10_01393	TYR_PHOSPHATASE_2 domain-containing protein. (650 aa)
	PV10_07379	Csm1 domain-containing protein. (504 aa)
	PV10_01565	Uds1 domain-containing protein. (817 aa)
	PV10_01633	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (517 aa)
	PV10_07519	Uncharacterized protein. (1218 aa)
	PV10_01687	Uncharacterized protein. (750 aa)
	PV10_01701	Uncharacterized protein. (158 aa)
	PV10_01377	Uncharacterized protein. (296 aa)
	PAC1	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (457 aa)
	PV10_05566	Mannan endo-1,6-alpha-mannosidase. (456 aa)
	PV10_05670	CRIB domain-containing protein. (751 aa)
	PV10_05704	Uncharacterized protein. (1779 aa)
	PV10_05878	Protein kinase domain-containing protein. (759 aa)
	PV10_06238	Uncharacterized protein. (305 aa)
	PV10_04344	Uncharacterized protein. (710 aa)
	PV10_04406	Rhodanese domain-containing protein. (566 aa)
	PV10_04661	WD_REPEATS_REGION domain-containing protein. (702 aa)
	PV10_05014	Uncharacterized protein. (2655 aa)
	PV10_05023	Serine/threonine-protein phosphatase. (404 aa)
	PV10_05150	DHR10 domain-containing protein. (459 aa)
	PV10_02386	Uncharacterized protein. (543 aa)
	PV10_02442	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1219 aa)
	PV10_02466	Cell division control protein; Belongs to the CDC6/cdc18 family. (624 aa)
	PV10_02707	Uncharacterized protein. (1663 aa)
	PV10_03144	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (137 aa)
	PV10_03539	Uncharacterized protein. (755 aa)
	PV10_00104	Uncharacterized protein. (2011 aa)
	PV10_00224	Structural maintenance of chromosomes protein. (1532 aa)
	PV10_00249	DUF1767 domain-containing protein. (290 aa)
	PV10_00323	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1225 aa)
	PV10_00793	Uncharacterized protein. (1055 aa)
	PV10_00864	Uncharacterized protein. (811 aa)
	PV10_00921	Uncharacterized protein. (424 aa)
	PV10_00930	Uncharacterized protein. (418 aa)
	PV10_09000	Uncharacterized protein. (247 aa)
	PV10_07984	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (338 aa)
	PV10_08086	AIP3 domain-containing protein. (1143 aa)
	PV10_08138	Uncharacterized protein. (425 aa)
	PV10_08153	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (528 aa)
	PV10_08793	Uncharacterized protein. (309 aa)
	PV10_07050	Uncharacterized protein. (335 aa)
	PV10_07233	Structural maintenance of chromosomes protein. (1183 aa)
	PV10_07634	Non-specific serine/threonine protein kinase. (871 aa)
	PV10_05499	Structural maintenance of chromosomes protein. (1256 aa)
	PV10_05603	Checkpoint protein; Belongs to the HUS1 family. (351 aa)
	PV10_05679	GTP-binding protein rhoC. (281 aa)
	B0A52_05041	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (381 aa)
	PV10_05976	CADG domain-containing protein. (441 aa)
	PV10_06052	Uncharacterized protein. (650 aa)
	PV10_06262	Myosin-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1273 aa)
	PV10_03962	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (152 aa)
	PV10_04197	Uncharacterized protein. (435 aa)
	PV10_04324	TPR_REGION domain-containing protein. (746 aa)
	PV10_04398	SH3 domain-containing protein. (1178 aa)
	PV10_04422	Uncharacterized protein. (808 aa)
	PV10_04798	Arrestin_C domain-containing protein. (401 aa)
	PV10_04956	Uncharacterized protein. (115 aa)
	PV10_05089	Uncharacterized protein; Belongs to the actin family. (439 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_00951	B0A52_06474	A0A0D1Z672	A0A0D1ZAQ6	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Actin, gamma.	0.987
B0A52_00951	B0A52_09198	A0A0D1Z672	A0A0D1X0Y8	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Cell division control protein 42.	0.766
B0A52_00951	PV10_00793	A0A0D1Z672	A0A0D2ADN0	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.406
B0A52_00951	PV10_03062	A0A0D1Z672	A0A0D2A8U8	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.502
B0A52_00951	PV10_03539	A0A0D1Z672	A0A0D2AAK1	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.829
B0A52_00951	PV10_03962	A0A0D1Z672	A0A0D1WTY5	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.803
B0A52_00951	PV10_04063	A0A0D1Z672	A0A0D1ZDK7	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.673
B0A52_00951	PV10_04197	A0A0D1Z672	A0A0D1WUL1	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.439
B0A52_00951	PV10_05089	A0A0D1Z672	A0A0D1WWZ8	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein; Belongs to the actin family.	0.889
B0A52_00951	PV10_05670	A0A0D1Z672	A0A0D1ZWC8	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	CRIB domain-containing protein.	0.420
B0A52_00951	PV10_05679	A0A0D1Z672	A0A0D1WPY8	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	GTP-binding protein rhoC.	0.691
B0A52_00951	PV10_05704	A0A0D1Z672	A0A0D1ZWF7	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.927
B0A52_00951	PV10_05740	A0A0D1Z672	A0A0D1XSQ5	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.469
B0A52_00951	PV10_05834	A0A0D1Z672	A0A0D1ZBA8	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.422
B0A52_00951	PV10_06294	A0A0D1Z672	A0A0D1XUC0	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Uncharacterized protein.	0.513
B0A52_00951	PV10_08086	A0A0D1Z672	A0A0D1WHV6	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	AIP3 domain-containing protein.	0.645
B0A52_00951	PV10_08166	A0A0D1Z672	A0A0D1ZP05	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	Protein kinase domain-containing protein.	0.445
B0A52_01520	B0A52_01677	A0A0D1Z5G8	A0A0D1ZSU4	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.757
B0A52_01520	B0A52_05041	A0A0D1Z5G8	A0A0D1WQJ1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.548
B0A52_01520	B0A52_06474	A0A0D1Z5G8	A0A0D1ZAQ6	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Actin, gamma.	0.575