STRINGSTRING
PV10_08081 PV10_08081 PV10_08268 PV10_08268 PV10_08517 PV10_08517 PV10_08751 PV10_08751 PV10_07026 PV10_07026 PV10_07055 PV10_07055 PV10_07274 PV10_07274 PV10_07405 PV10_07405 PV10_07876 PV10_07876 PV10_05702 PV10_05702 PV10_06401 PV10_06401 PV10_04663 PV10_04663 PV10_04946 PV10_04946 PV10_05011 PV10_05011 PV10_02119 PV10_02119 MCM7 MCM7 PV10_02626 PV10_02626 PV10_02782 PV10_02782 PV10_02985 PV10_02985 PV10_03009 PV10_03009 PV10_03088 PV10_03088 PV10_03105 PV10_03105 PV10_03455 PV10_03455 SLX4 SLX4 PV10_00187 PV10_00187 PV10_00207 PV10_00207 PV10_00216 PV10_00216 PV10_00657 PV10_00657 PV10_00822 PV10_00822 PV10_01221 PV10_01221 PV10_01284 PV10_01284 PV10_01680 PV10_01680 PV10_01903 PV10_01903 PV10_08562 PV10_08562 B0A52_04315 B0A52_04315 PV10_08739 PV10_08739 PV10_08932 PV10_08932 PV10_07087 PV10_07087 PV10_07867 PV10_07867 PV10_05315 PV10_05315 PV10_05490 PV10_05490 PV10_05907 PV10_05907 PV10_06115 PV10_06115 PV10_06521 PV10_06521 PV10_03688 PV10_03688 PV10_04470 PV10_04470 PV10_02986 PV10_02986 FEN1 FEN1 PV10_03291 PV10_03291 PV10_03580 PV10_03580 PV10_00164 PV10_00164 PV10_00499 PV10_00499 NTH1 NTH1 PV10_01113 PV10_01113 PV10_01241 PV10_01241 PV10_01821 PV10_01821 PV10_09167 PV10_09167 PV10_08001 PV10_08001 PV10_08108 PV10_08108 PV10_09195 PV10_09195 PV10_09126 PV10_09126 PV10_08813 PV10_08813 PV10_08240 PV10_08240 PV10_08424 PV10_08424 PV10_07414 PV10_07414 PV10_08948 PV10_08948 PV10_06954 PV10_06954 PV10_05473 PV10_05473 PV10_07520 PV10_07520 PV10_05570 PV10_05570 PV10_07827 PV10_07827 UNG1 UNG1 PV10_05421 PV10_05421 PV10_06269 PV10_06269 SLX1 SLX1 PV10_06650 PV10_06650 PV10_06399 PV10_06399 PV10_06476 PV10_06476 PV10_06514 PV10_06514 PV10_06523 PV10_06523 PV10_04188 PV10_04188 PV10_06736 PV10_06736 PV10_03810 PV10_03810 PV10_03991 PV10_03991 PV10_04813 PV10_04813 PV10_04133 PV10_04133 PV10_04196 PV10_04196 PV10_04309 PV10_04309 PV10_04426 PV10_04426 PIF1 PIF1 PV10_02145 PV10_02145 PV10_02214 PV10_02214 PV10_02437 PV10_02437 PV10_02711 PV10_02711 PV10_02798 PV10_02798 PV10_02216 PV10_02216 PV10_02403 PV10_02403 PV10_03252 PV10_03252 PV10_02663 PV10_02663 PV10_03287 PV10_03287 PV10_03373 PV10_03373 PV10_02741 PV10_02741 PV10_02860 PV10_02860 PV10_02878 PV10_02878 PV10_02984 PV10_02984 PV10_09120 PV10_09120 PV10_00213 PV10_00213 PV10_03556 PV10_03556 PV10_03601 PV10_03601 PV10_06819 PV10_06819 PV10_07084 PV10_07084 PV10_00679 PV10_00679 PV10_00814 PV10_00814 PV10_07363 PV10_07363 PV10_01283 PV10_01283 PV10_01567 PV10_01567 PV10_05344 PV10_05344 PV10_01834 PV10_01834 PV10_05932 PV10_05932 PV10_06154 PV10_06154 PV10_06346 PV10_06346 PV10_06379 PV10_06379 PV10_06691 PV10_06691 PV10_04153 PV10_04153 PV10_04246 PV10_04246 PV10_04448 PV10_04448 PV10_04479 PV10_04479 PV10_04918 PV10_04918 PV10_02294 PV10_02294 PV10_00133 PV10_00133 PV10_00376 PV10_00376 PV10_01431 PV10_01431 PV10_01828 PV10_01828
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PV10_08081DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
PV10_08268Zn(2)-C6 fungal-type domain-containing protein. (753 aa)
PV10_08517BRCT domain-containing protein. (714 aa)
PV10_08751Uncharacterized protein. (945 aa)
PV10_07026Zn(2)-C6 fungal-type domain-containing protein. (792 aa)
PV10_07055Zn(2)-C6 fungal-type domain-containing protein. (656 aa)
PV10_07274Uncharacterized protein. (1195 aa)
PV10_07405Zn(2)-C6 fungal-type domain-containing protein. (691 aa)
PV10_07876Uncharacterized protein. (884 aa)
PV10_05702Uncharacterized protein. (1460 aa)
PV10_06401Uncharacterized protein. (1024 aa)
PV10_04663DNA ligase. (1035 aa)
PV10_04946Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (758 aa)
PV10_05011DNA_mis_repair domain-containing protein. (740 aa)
PV10_02119Uncharacterized protein. (1418 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (808 aa)
PV10_02626Uncharacterized protein. (660 aa)
PV10_02782MutL_C domain-containing protein. (876 aa)
PV10_02985Uncharacterized protein. (642 aa)
PV10_03009Zn(2)-C6 fungal-type domain-containing protein. (725 aa)
PV10_03088AP_endonuc_2 domain-containing protein. (534 aa)
PV10_03105DNA ligase. (855 aa)
PV10_03455AAA_23 domain-containing protein. (1306 aa)
SLX4Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (919 aa)
PV10_00187Uncharacterized protein. (1122 aa)
PV10_00207Rad51 domain-containing protein. (403 aa)
PV10_00216Uncharacterized protein. (1570 aa)
PV10_00657Uncharacterized protein. (436 aa)
PV10_00822Uncharacterized protein. (1249 aa)
PV10_01221Uncharacterized protein. (714 aa)
PV10_01284Helicase ATP-binding domain-containing protein. (470 aa)
PV10_01680Uncharacterized protein. (918 aa)
PV10_01903Uncharacterized protein. (1026 aa)
PV10_08562Uncharacterized protein. (1692 aa)
B0A52_04315DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (350 aa)
PV10_08739Uncharacterized protein. (1665 aa)
PV10_08932Endo/exonuclease/phosphatase domain-containing protein. (384 aa)
PV10_07087DNA polymerase. (1453 aa)
PV10_07867DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (693 aa)
PV10_05315Uncharacterized protein. (392 aa)
PV10_05490UmuC domain-containing protein. (652 aa)
PV10_05907Uncharacterized protein. (1860 aa)
PV10_06115Uncharacterized protein. (1674 aa)
PV10_06521Uncharacterized protein. (1608 aa)
PV10_03688DNA_MISMATCH_REPAIR_2 domain-containing protein. (681 aa)
PV10_04470POLAc domain-containing protein. (1157 aa)
PV10_02986Uncharacterized protein. (988 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
PV10_03291DRMBL domain-containing protein. (937 aa)
PV10_03580Uncharacterized protein. (1124 aa)
PV10_00164DNA mismatch repair protein msh-2; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
PV10_00499SMC_N domain-containing protein. (1145 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (437 aa)
PV10_01113DNA ligase. (870 aa)
PV10_01241Exodeoxyribonuclease III. (613 aa)
PV10_01821RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (457 aa)
PV10_09167RECA_2 domain-containing protein. (481 aa)
PV10_08001Uncharacterized protein. (1540 aa)
PV10_08108ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
PV10_09195Uncharacterized protein. (1087 aa)
PV10_09126Uncharacterized protein. (500 aa)
PV10_08813Uncharacterized protein. (1012 aa)
PV10_08240Formamidopyrimidine-DNA glycosylase. (448 aa)
PV10_08424Zn(2)-C6 fungal-type domain-containing protein. (916 aa)
PV10_07414Uncharacterized protein. (1203 aa)
PV10_08948Uncharacterized protein. (1891 aa)
PV10_06954Uncharacterized protein. (638 aa)
PV10_05473ERCC4 domain-containing protein. (948 aa)
PV10_07520ENDO3c domain-containing protein. (419 aa)
PV10_05570Photolyase/cryptochrome alpha/beta domain-containing protein. (624 aa)
PV10_07827Fungal_trans domain-containing protein. (705 aa)
UNG1Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (434 aa)
PV10_05421Ydc2-catalyt domain-containing protein. (336 aa)
PV10_06269zf-GRF domain-containing protein. (360 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (399 aa)
PV10_06650DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (902 aa)
PV10_06399Uncharacterized protein. (154 aa)
PV10_06476Uncharacterized protein. (1040 aa)
PV10_06514DNA helicase; Belongs to the MCM family. (1004 aa)
PV10_06523Uncharacterized protein. (403 aa)
PV10_04188Uncharacterized protein. (719 aa)
PV10_06736Uncharacterized protein. (846 aa)
PV10_03810Uncharacterized protein. (1152 aa)
PV10_03991RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (485 aa)
PV10_04813DNA polymerase. (1107 aa)
PV10_04133Uncharacterized protein. (1099 aa)
PV10_04196Uncharacterized protein. (605 aa)
PV10_04309DNA_LIGASE_A3 domain-containing protein. (1122 aa)
PV10_04426HD domain-containing protein. (232 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (825 aa)
PV10_02145Uncharacterized protein. (1007 aa)
PV10_02214RRN9 domain-containing protein. (740 aa)
PV10_02437Uncharacterized protein. (1343 aa)
PV10_02711DNA repair helicase rad15. (818 aa)
PV10_02798Structural maintenance of chromosomes protein. (1205 aa)
PV10_02216DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1221 aa)
PV10_02403UmuC domain-containing protein. (723 aa)
PV10_03252DNA_mis_repair domain-containing protein. (909 aa)
PV10_02663DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1474 aa)
PV10_03287Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (997 aa)
PV10_03373UDG domain-containing protein. (345 aa)
PV10_02741ENDO3c domain-containing protein. (487 aa)
PV10_02860Uncharacterized protein. (746 aa)
PV10_02878Zn(2)-C6 fungal-type domain-containing protein. (714 aa)
PV10_02984DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1098 aa)
PV10_09120SnoaL-like domain-containing protein. (139 aa)
PV10_00213Uncharacterized protein. (747 aa)
PV10_03556Zn(2)-C6 fungal-type domain-containing protein. (863 aa)
PV10_03601Photolyase/cryptochrome alpha/beta domain-containing protein. (604 aa)
PV10_06819RECA_2 domain-containing protein. (564 aa)
PV10_07084DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2242 aa)
PV10_00679Uncharacterized protein. (659 aa)
PV10_00814ERCC4 domain-containing protein. (612 aa)
PV10_07363DNA_MISMATCH_REPAIR_2 domain-containing protein. (1006 aa)
PV10_01283SEC63 domain-containing protein. (615 aa)
PV10_01567DNA polymerase. (1698 aa)
PV10_05344ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (513 aa)
PV10_01834UmuC domain-containing protein. (603 aa)
PV10_05932DNA helicase; Belongs to the MCM family. (963 aa)
PV10_06154SAP domain-containing protein. (684 aa)
PV10_06346Endonuclease. (345 aa)
PV10_06379Abhydrolase_3 domain-containing protein. (282 aa)
PV10_06691TP6A_N domain-containing protein. (370 aa)
PV10_04153DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1162 aa)
PV10_04246Uncharacterized protein. (611 aa)
PV10_04448Uncharacterized protein. (1153 aa)
PV10_04479zf-C2HE domain-containing protein. (273 aa)
PV10_04918Uncharacterized protein. (1151 aa)
PV10_02294Uncharacterized protein. (504 aa)
PV10_00133Uncharacterized protein. (804 aa)
PV10_00376Helicase ATP-binding domain-containing protein. (854 aa)
PV10_01431Replication factor C subunit 1. (1078 aa)
PV10_01828Uncharacterized protein. (560 aa)
Your Current Organism:
Exophiala mesophila
NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila
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