27 items (Exophiala mesophila) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	PV10_01435	Protein kinase domain-containing protein. (1483 aa)
	PV10_07469	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2306 aa)
	PV10_08081	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
	PV10_05073	Protein kinase domain-containing protein. (755 aa)
	PV10_03548	Uncharacterized protein. (705 aa)
	PV10_01621	Protein kinase domain-containing protein. (348 aa)
	PV10_09001	Zn(2)-C6 fungal-type domain-containing protein. (728 aa)
	PV10_09023	Fungal_trans domain-containing protein. (842 aa)
	PV10_05994	Protein kinase domain-containing protein. (531 aa)
	PV10_06521	Uncharacterized protein. (1608 aa)
	PV10_03929	Uncharacterized protein. (1026 aa)
	PV10_03207	Polyubiquitin. (229 aa)
	PV10_01591	Zn(2)-C6 fungal-type domain-containing protein. (757 aa)
	PV10_07946	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (272 aa)
	PV10_08687	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (460 aa)
	PV10_07844	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa)
	B0A52_01786	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
	PV10_08689	BZIP domain-containing protein. (291 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (607 aa)
	PV10_06269	zf-GRF domain-containing protein. (360 aa)
	PV10_06358	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (568 aa)
	PV10_04194	Uncharacterized protein. (886 aa)
	PV10_02293	Uncharacterized protein. (688 aa)
	PV10_03643	Protein kinase domain-containing protein. (527 aa)
	PV10_00249	DUF1767 domain-containing protein. (290 aa)
	B0A52_00659	Ubiquitin-40S ribosomal protein S27a. (154 aa)
	PV10_08688	Zn(2)-C6 fungal-type domain-containing protein. (754 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_00659	PV10_00249	A0A0D1ZQI9	A0A0D2ABR5	Ubiquitin-40S ribosomal protein S27a.	DUF1767 domain-containing protein.	0.619
B0A52_00659	PV10_01435	A0A0D1ZQI9	A0A0D1ZT11	Ubiquitin-40S ribosomal protein S27a.	Protein kinase domain-containing protein.	0.512
B0A52_00659	PV10_02293	A0A0D1ZQI9	A0A0D1ZJ01	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.636
B0A52_00659	PV10_03207	A0A0D1ZQI9	A0A0D1Y4J0	Ubiquitin-40S ribosomal protein S27a.	Polyubiquitin.	0.969
B0A52_00659	PV10_06521	A0A0D1ZQI9	A0A0D1XUZ4	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.627
B0A52_00659	PV10_07844	A0A0D1ZQI9	A0A0D1ZUU4	Ubiquitin-40S ribosomal protein S27a.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.633
B0A52_01786	PV10_01591	A0A0D1Z4M9	A0A0D1YB81	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Zn(2)-C6 fungal-type domain-containing protein.	0.846
B0A52_01786	PV10_03643	A0A0D1Z4M9	A0A0D1ZN94	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.472
B0A52_01786	PV10_03929	A0A0D1Z4M9	A0A0D1XWQ7	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.954
B0A52_01786	PV10_05073	A0A0D1Z4M9	A0A0D1WWX4	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.509
B0A52_01786	PV10_05994	A0A0D1Z4M9	A0A0D1XTH6	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.408
B0A52_01786	PV10_06358	A0A0D1Z4M9	A0A0D1ZB07	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.957
B0A52_01786	PV10_07946	A0A0D1Z4M9	A0A0D1Z2U0	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.999
B0A52_01786	PV10_08687	A0A0D1Z4M9	A0A0D1Z2U5	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.985
B0A52_01786	PV10_08688	A0A0D1Z4M9	A0A0D1ZQP2	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Zn(2)-C6 fungal-type domain-containing protein.	0.846
B0A52_01786	PV10_09001	A0A0D1Z4M9	A0A0D1XIT5	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Zn(2)-C6 fungal-type domain-containing protein.	0.846
B0A52_01786	PV10_09023	A0A0D1Z4M9	A0A0D1XIV4	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Fungal_trans domain-containing protein.	0.846
MDM34	PV10_01591	A0A0D1Z6L0	A0A0D1YB81	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Zn(2)-C6 fungal-type domain-containing protein.	0.846
MDM34	PV10_03929	A0A0D1Z6L0	A0A0D1XWQ7	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Uncharacterized protein.	0.909
MDM34	PV10_06358	A0A0D1Z6L0	A0A0D1ZB07	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.911