48 items (Exophiala mesophila) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_06514	DNA helicase; Belongs to the MCM family. (1004 aa)
	PV10_04131	Metallophos domain-containing protein. (433 aa)
	PV10_04579	Uncharacterized protein. (132 aa)
	PV10_04229	Uncharacterized protein. (444 aa)
	PV10_04585	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (675 aa)
	PV10_04710	CBFD_NFYB_HMF domain-containing protein. (185 aa)
	PV10_02150	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (413 aa)
	PV10_02098	RING-type domain-containing protein. (269 aa)
	PV10_02922	Zf-primase domain-containing protein. (781 aa)
	PV10_08569	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (477 aa)
	B0A52_00659	Ubiquitin-40S ribosomal protein S27a. (154 aa)
	PV10_00844	Uncharacterized protein. (474 aa)
	PV10_00324	Protein kinase domain-containing protein. (573 aa)
	PV10_07084	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2242 aa)
	PV10_07844	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa)
	PV10_01469	DNA helicase; Belongs to the MCM family. (915 aa)
	PV10_05932	DNA helicase; Belongs to the MCM family. (963 aa)
	PV10_06044	Uncharacterized protein. (560 aa)
	PV10_03762	Uncharacterized protein. (370 aa)
	PV10_04167	Uncharacterized protein. (277 aa)
	PV10_04406	Rhodanese domain-containing protein. (566 aa)
	PV10_03294	Uncharacterized protein. (790 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (808 aa)
	PV10_04833	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (750 aa)
	PV10_03739	J domain-containing protein. (323 aa)
	PV10_08689	BZIP domain-containing protein. (291 aa)
	PV10_08112	Uncharacterized protein. (158 aa)
	PV10_01681	DNA helicase; Belongs to the MCM family. (863 aa)
	PV10_03207	Polyubiquitin. (229 aa)
	PV10_04251	DNA helicase; Belongs to the MCM family. (724 aa)
	PV10_07563	ORC_WH_C domain-containing protein. (761 aa)
	PV10_07553	Serine/threonine-protein kinase pef1; Belongs to the protein kinase superfamily. (412 aa)
	PV10_04096	Uncharacterized protein. (583 aa)
	PV10_06478	DBF4-type domain-containing protein. (656 aa)
	B0A52_01520	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (328 aa)
	PV10_05897	CYCLIN domain-containing protein; Belongs to the cyclin family. (403 aa)
	PV10_07753	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (507 aa)
	PV10_06484	Zds_C domain-containing protein. (930 aa)
	PV10_06387	DNA_pol_E_B domain-containing protein. (856 aa)
	PV10_07087	DNA polymerase. (1453 aa)
	PV10_00523	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (530 aa)
	PV10_01372	CBFD_NFYB_HMF domain-containing protein. (349 aa)
	PV10_03144	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (137 aa)
	PV10_02688	Uncharacterized protein. (507 aa)
	PV10_02657	Uncharacterized protein. (791 aa)
	PV10_02466	Cell division control protein; Belongs to the CDC6/cdc18 family. (624 aa)
	PV10_02041	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
	PV10_04499	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (654 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_00659	B0A52_01520	A0A0D1ZQI9	A0A0D1Z5G8	Ubiquitin-40S ribosomal protein S27a.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.728
B0A52_00659	MCM7	A0A0D1ZQI9	A0A0D1WY54	Ubiquitin-40S ribosomal protein S27a.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.693
B0A52_00659	PV10_00844	A0A0D1ZQI9	A0A0D1ZR37	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.638
B0A52_00659	PV10_01372	A0A0D1ZQI9	A0A0D2AFH7	Ubiquitin-40S ribosomal protein S27a.	CBFD_NFYB_HMF domain-containing protein.	0.646
B0A52_00659	PV10_01681	A0A0D1ZQI9	A0A0D1YBK4	Ubiquitin-40S ribosomal protein S27a.	DNA helicase; Belongs to the MCM family.	0.645
B0A52_00659	PV10_02041	A0A0D1ZQI9	A0A0D2A5G3	Ubiquitin-40S ribosomal protein S27a.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.658
B0A52_00659	PV10_02098	A0A0D1ZQI9	A0A0D1ZK71	Ubiquitin-40S ribosomal protein S27a.	RING-type domain-containing protein.	0.667
B0A52_00659	PV10_02150	A0A0D1ZQI9	A0A0D1ZIF2	Ubiquitin-40S ribosomal protein S27a.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.707
B0A52_00659	PV10_02466	A0A0D1ZQI9	A0A0D2A6T2	Ubiquitin-40S ribosomal protein S27a.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.710
B0A52_00659	PV10_02688	A0A0D1ZQI9	A0A0D2A7N4	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.461
B0A52_00659	PV10_03144	A0A0D1ZQI9	A0A0D2A957	Ubiquitin-40S ribosomal protein S27a.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.776
B0A52_00659	PV10_03207	A0A0D1ZQI9	A0A0D1Y4J0	Ubiquitin-40S ribosomal protein S27a.	Polyubiquitin.	0.969
B0A52_00659	PV10_03294	A0A0D1ZQI9	A0A0D1X1M7	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.461
B0A52_00659	PV10_03762	A0A0D1ZQI9	A0A0D2A0A3	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.681
B0A52_00659	PV10_04131	A0A0D1ZQI9	A0A0D1ZDS9	Ubiquitin-40S ribosomal protein S27a.	Metallophos domain-containing protein.	0.629
B0A52_00659	PV10_04167	A0A0D1ZQI9	A0A0D2A1J8	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.665
B0A52_00659	PV10_04229	A0A0D1ZQI9	A0A0D1ZGR5	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.461
B0A52_00659	PV10_04251	A0A0D1ZQI9	A0A0D1XXT6	Ubiquitin-40S ribosomal protein S27a.	DNA helicase; Belongs to the MCM family.	0.666
B0A52_00659	PV10_04406	A0A0D1ZQI9	A0A0D2A275	Ubiquitin-40S ribosomal protein S27a.	Rhodanese domain-containing protein.	0.631
B0A52_00659	PV10_04579	A0A0D1ZQI9	A0A0D1ZF32	Ubiquitin-40S ribosomal protein S27a.	Uncharacterized protein.	0.461