(65 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Exophiala mesophila)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PV10_04047	Uncharacterized protein. (559 aa)
	PV10_08770	Aminotran_1_2 domain-containing protein. (365 aa)
	PV10_05484	Uncharacterized protein. (329 aa)
	PV10_05835	Uncharacterized protein. (567 aa)
	PV10_04329	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (249 aa)
	PV10_04842	Zn(2)-C6 fungal-type domain-containing protein. (740 aa)
	PV10_05183	Fungal_trans domain-containing protein. (774 aa)
	PV10_02732	FAD_binding_3 domain-containing protein. (607 aa)
	PV10_02948	Uncharacterized protein. (1142 aa)
	PV10_03309	Uncharacterized protein. (547 aa)
	PV10_03313	Uncharacterized protein. (560 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (240 aa)
	B0A52_01250	4HBT domain-containing protein. (172 aa)
	PV10_00780	3-dmu-9_3-mt domain-containing protein. (173 aa)
	PV10_00901	Uncharacterized protein. (640 aa)
	PV10_08297	4HBT domain-containing protein. (181 aa)
	PV10_08302	Uncharacterized protein. (568 aa)
	PV10_08752	NAD(P)H:quinone oxidoreductase, type IV. (204 aa)
	PV10_07121	Uncharacterized protein. (261 aa)
	PV10_05536	AB hydrolase-1 domain-containing protein. (324 aa)
	PV10_06391	VOC domain-containing protein. (837 aa)
	PV10_05026	Uncharacterized protein. (558 aa)
	PV10_02153	Aminotran_1_2 domain-containing protein. (412 aa)
	PV10_02430	Uncharacterized protein. (578 aa)
	PV10_02572	Uncharacterized protein. (565 aa)
	PV10_02728	Uncharacterized protein. (559 aa)
	PV10_03165	Uncharacterized protein. (561 aa)
	PV10_00587	Uncharacterized protein. (562 aa)
	PV10_01714	Zn(2)-C6 fungal-type domain-containing protein. (739 aa)
	PV10_01938	Aminotran_1_2 domain-containing protein. (398 aa)
	PV10_09189	Uncharacterized protein. (565 aa)
	PV10_08318	Uncharacterized protein. (301 aa)
	PV10_07438	4-hydroxyphenylpyruvate dioxygenase. (420 aa)
	PV10_07897	4HBT domain-containing protein. (149 aa)
	PV10_07254	Aminotran_1_2 domain-containing protein. (557 aa)
	PV10_07484	Uncharacterized protein. (594 aa)
	PV10_07548	Fungal_trans domain-containing protein. (548 aa)
	PV10_05365	Uncharacterized protein. (579 aa)
	PV10_06049	FAD_binding_3 domain-containing protein. (634 aa)
	PV10_05748	FAD_binding_3 domain-containing protein. (433 aa)
	PV10_03727	FAD_binding_3 domain-containing protein. (616 aa)
	PV10_03910	Uncharacterized protein. (542 aa)
	COQ5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (305 aa)
	PV10_04254	Aminotran_1_2 domain-containing protein. (614 aa)
	PV10_04434	FAD_binding_3 domain-containing protein. (553 aa)
	PV10_05058	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (340 aa)
	PV10_02750	FAD_binding_3 domain-containing protein. (648 aa)
	PV10_03412	4HBT domain-containing protein. (179 aa)
	PV10_09072	Uncharacterized protein. (556 aa)
	PV10_03662	4HBT domain-containing protein. (165 aa)
	PV10_08044	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (426 aa)
	PV10_00777	FAD_binding_3 domain-containing protein. (593 aa)
	PV10_01040	FAD_binding_3 domain-containing protein. (410 aa)
	PV10_07053	Uncharacterized protein. (580 aa)
	PV10_01061	Uncharacterized protein. (250 aa)
	PV10_07547	Fungal_trans domain-containing protein. (599 aa)
	PV10_01715	FAD_binding_3 domain-containing protein. (405 aa)
	PV10_01432	Uncharacterized protein. (575 aa)
	PV10_06315	FAD_binding_3 domain-containing protein. (415 aa)
	PV10_06320	FAD_binding_3 domain-containing protein. (602 aa)
	PV10_06569	Uncharacterized protein. (554 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (531 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (313 aa)
	PV10_03568	FAD_binding_3 domain-containing protein. (414 aa)
	PV10_01041	Zn(2)-C6 fungal-type domain-containing protein. (780 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_01250	PV10_03662	A0A0D1X4A0	A0A0D1ZNA3	4HBT domain-containing protein.	4HBT domain-containing protein.	0.644
COQ3	COQ5	A0A0D2A9E7	A0A0D1ZE36	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.753
COQ3	COQ6	A0A0D2A9E7	A0A0D2A9C5	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.962
COQ3	COQ7	A0A0D2A9E7	A0A0D1X3K3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	0.922
COQ3	PV10_00777	A0A0D2A9E7	A0A0D1ZQW6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_00780	A0A0D2A9E7	A0A0D1X586	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	3-dmu-9_3-mt domain-containing protein.	0.555
COQ3	PV10_01040	A0A0D2A9E7	A0A0D1ZRN8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_01041	A0A0D2A9E7	A0A0D2AED3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Zn(2)-C6 fungal-type domain-containing protein.	0.561
COQ3	PV10_01714	A0A0D2A9E7	A0A0D1YBN8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Zn(2)-C6 fungal-type domain-containing protein.	0.561
COQ3	PV10_01715	A0A0D2A9E7	A0A0D1ZU22	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_02732	A0A0D2A9E7	A0A0D1WZW7	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_02750	A0A0D2A9E7	A0A0D1ZM83	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_03568	A0A0D2A9E7	A0A0D2AAP5	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_03727	A0A0D2A9E7	A0A0D1ZCM1	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_04434	A0A0D2A9E7	A0A0D1ZHA8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_04842	A0A0D2A9E7	A0A0D1WW96	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Zn(2)-C6 fungal-type domain-containing protein.	0.561
COQ3	PV10_05183	A0A0D2A9E7	A0A0D1WXC6	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Fungal_trans domain-containing protein.	0.561
COQ3	PV10_05748	A0A0D2A9E7	A0A0D1ZB23	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_06049	A0A0D2A9E7	A0A0D1ZA33	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561
COQ3	PV10_06315	A0A0D2A9E7	A0A0D1ZY46	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.561