(69 nodes) Pyrimidine metabolism network (Exophiala mesophila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_09215	MFS domain-containing protein. (559 aa)
	PV10_09068	Uncharacterized protein. (209 aa)
	PV10_08177	GTP-binding protein YchF. (393 aa)
	PV10_08301	Zn(2)-C6 fungal-type domain-containing protein. (736 aa)
	PV10_08724	Uncharacterized protein. (180 aa)
	PV10_08902	Zn(2)-C6 fungal-type domain-containing protein. (715 aa)
	PV10_06876	Dihydroorotate dehydrogenase (Fumarate). (502 aa)
	PV10_07432	Thymidylate synthase. (378 aa)
	PV10_07446	HD domain-containing protein. (279 aa)
	PV10_07476	Uncharacterized protein. (139 aa)
	PV10_03879	Dihydroorotase, homodimeric type. (366 aa)
	PV10_03884	CBFD_NFYB_HMF domain-containing protein. (101 aa)
	PV10_04011	Dihydropyrimidinase. (494 aa)
	PV10_04994	Uncharacterized protein; Belongs to the GroES chaperonin family. (107 aa)
	PV10_05174	Ribonucleoside-diphosphate reductase small chain. (417 aa)
	PV10_02601	Uncharacterized protein. (465 aa)
	PV10_02884	IU_nuc_hydro domain-containing protein. (347 aa)
	PV10_03236	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (273 aa)
	PV10_00675	MFS domain-containing protein. (522 aa)
	PV10_00684	Uncharacterized protein. (527 aa)
	PV10_01303	Deoxyuridine 5'-triphosphate nucleotidohydrolase. (206 aa)
	PV10_08278	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (909 aa)
	PV10_07610	PfkB domain-containing protein. (805 aa)
	PV10_07668	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (455 aa)
	PV10_06065	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (634 aa)
	PV10_03807	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (714 aa)
	PV10_04202	TLC domain-containing protein. (141 aa)
	PV10_04817	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (340 aa)
	PV10_02548	Uncharacterized protein. (608 aa)
	PV10_01189	CMP/dCMP-type deaminase domain-containing protein. (150 aa)
	PV10_01207	Uncharacterized protein; Belongs to the adenylate kinase family. (217 aa)
	PV10_09035	IU_nuc_hydro domain-containing protein. (360 aa)
	PV10_08117	Uncharacterized protein. (89 aa)
	PV10_08308	DHO_dh domain-containing protein. (361 aa)
	PV10_07203	Orotate phosphoribosyltransferase. (245 aa)
	PV10_08957	F-box domain-containing protein. (747 aa)
	PV10_07731	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (159 aa)
	PV10_06995	Metallophos domain-containing protein. (605 aa)
	PV10_05542	Uracil phosphoribosyltransferase. (253 aa)
	PV10_07927	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (605 aa)
	PV10_06699	Uncharacterized protein. (311 aa)
	PV10_06087	Zn(2)-C6 fungal-type domain-containing protein. (743 aa)
	PV10_06766	Uncharacterized protein. (426 aa)
	B0A52_09078	Uracil phosphoribosyltransferase. (199 aa)
	PV10_03883	Uncharacterized protein. (449 aa)
	PV10_04887	Protein pyrABCN. (2294 aa)
	B0A52_04949	Nucleoside diphosphate kinase. (153 aa)
	PV10_04431	RED_N domain-containing protein. (525 aa)
	PV10_05195	Uridine kinase; Belongs to the uridine kinase family. (476 aa)
	PV10_04561	Uracil phosphoribosyltransferase. (226 aa)
	PV10_04590	Uracil phosphoribosyltransferase. (222 aa)
	PV10_03146	Uncharacterized protein. (400 aa)
	PV10_03273	MFS domain-containing protein. (525 aa)
	PV10_03414	Uncharacterized protein. (131 aa)
	PV10_03079	Uncharacterized protein. (142 aa)
	PV10_08204	IU_nuc_hydro domain-containing protein. (442 aa)
	PV10_07250	Carbamoyl-phosphate synthase, large subunit. (1164 aa)
	PV10_01406	OBG-type G domain-containing protein. (416 aa)
	PV10_01480	MFS domain-containing protein. (536 aa)
	PV10_01057	Zn(2)-C6 fungal-type domain-containing protein. (714 aa)
	PV10_06169	Carbamoyl-phosphate synthase arginine-specific small chain, variant. (479 aa)
	PV10_06583	Thymidylate kinase. (240 aa)
	PV10_04844	Importin N-terminal domain-containing protein. (1059 aa)
	PV10_02094	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (229 aa)
	PV10_02545	TLC domain-containing protein. (383 aa)
	PV10_02799	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (604 aa)
	PV10_03078	Uncharacterized protein. (102 aa)
	PV10_00476	Uncharacterized protein. (126 aa)
	PV10_01588	Nudix hydrolase domain-containing protein. (158 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_04949	B0A52_09078	A0A0D1ZH51	A0A0D1ZF18	Nucleoside diphosphate kinase.	Uracil phosphoribosyltransferase.	0.640
B0A52_04949	PV10_01207	A0A0D1ZH51	A0A0D1YA10	Nucleoside diphosphate kinase.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.801
B0A52_04949	PV10_01303	A0A0D1ZH51	A0A0D1X6W4	Nucleoside diphosphate kinase.	Deoxyuridine 5'-triphosphate nucleotidohydrolase.	0.830
B0A52_04949	PV10_01406	A0A0D1ZH51	A0A0D1ZSZ0	Nucleoside diphosphate kinase.	OBG-type G domain-containing protein.	0.514
B0A52_04949	PV10_01588	A0A0D1ZH51	A0A0D2AG38	Nucleoside diphosphate kinase.	Nudix hydrolase domain-containing protein.	0.781
B0A52_04949	PV10_02094	A0A0D1ZH51	A0A0D2A5M8	Nucleoside diphosphate kinase.	Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.801
B0A52_04949	PV10_02799	A0A0D1ZH51	A0A0D2A823	Nucleoside diphosphate kinase.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.901
B0A52_04949	PV10_03146	A0A0D1ZH51	A0A0D1ZLP2	Nucleoside diphosphate kinase.	Uncharacterized protein.	0.778
B0A52_04949	PV10_03807	A0A0D1ZH51	A0A0D1XWF1	Nucleoside diphosphate kinase.	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family.	0.771
B0A52_04949	PV10_03883	A0A0D1ZH51	A0A0D1ZFG6	Nucleoside diphosphate kinase.	Uncharacterized protein.	0.713
B0A52_04949	PV10_03884	A0A0D1ZH51	A0A0D1WTR8	Nucleoside diphosphate kinase.	CBFD_NFYB_HMF domain-containing protein.	0.713
B0A52_04949	PV10_04561	A0A0D1ZH51	A0A0D1ZHP0	Nucleoside diphosphate kinase.	Uracil phosphoribosyltransferase.	0.640
B0A52_04949	PV10_04590	A0A0D1ZH51	A0A0D1ZHR1	Nucleoside diphosphate kinase.	Uracil phosphoribosyltransferase.	0.640
B0A52_04949	PV10_04994	A0A0D1ZH51	A0A0D1WWN6	Nucleoside diphosphate kinase.	Uncharacterized protein; Belongs to the GroES chaperonin family.	0.537
B0A52_04949	PV10_05174	A0A0D1ZH51	A0A0D1WXB7	Nucleoside diphosphate kinase.	Ribonucleoside-diphosphate reductase small chain.	0.817
B0A52_04949	PV10_05195	A0A0D1ZH51	A0A0D1ZHG4	Nucleoside diphosphate kinase.	Uridine kinase; Belongs to the uridine kinase family.	0.640
B0A52_04949	PV10_05542	A0A0D1ZH51	A0A0D1Z889	Nucleoside diphosphate kinase.	Uracil phosphoribosyltransferase.	0.640
B0A52_04949	PV10_06583	A0A0D1ZH51	A0A0D1ZZ54	Nucleoside diphosphate kinase.	Thymidylate kinase.	0.866
B0A52_04949	PV10_06699	A0A0D1ZH51	A0A0D1ZC03	Nucleoside diphosphate kinase.	Uncharacterized protein.	0.755
B0A52_04949	PV10_06766	A0A0D1ZH51	A0A0D1ZEE5	Nucleoside diphosphate kinase.	Uncharacterized protein.	0.849