(95 nodes) Lysine degradation network (Exophiala mesophila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_04989	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
	PV10_05138	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (282 aa)
	PV10_02029	Zn(2)-C6 fungal-type domain-containing protein. (262 aa)
	PV10_02473	Uncharacterized protein. (411 aa)
	PV10_02694	SET domain-containing protein. (412 aa)
	PV10_03206	Uncharacterized protein. (621 aa)
	PV10_03327	Uncharacterized protein. (779 aa)
	PV10_00488	DAO domain-containing protein. (444 aa)
	PV10_00513	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (486 aa)
	PV10_00666	SET domain-containing protein. (413 aa)
	PV10_00760	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (491 aa)
	PV10_09228	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (300 aa)
	PV10_09096	SET domain-containing protein. (622 aa)
	PV10_08272	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (495 aa)
	PV10_07313	SET domain-containing protein. (944 aa)
	PV10_06105	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (482 aa)
	PV10_06204	DAO domain-containing protein. (437 aa)
	PV10_06722	SET domain-containing protein. (771 aa)
	PV10_03889	Uncharacterized protein. (389 aa)
	PV10_04491	Uncharacterized protein. (463 aa)
	PV10_04677	Uncharacterized protein. (217 aa)
	PV10_08418	SET domain-containing protein. (407 aa)
	PV10_08456	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (485 aa)
	PV10_00052	Uncharacterized protein. (431 aa)
	PV10_08674	Uncharacterized protein. (450 aa)
	PV10_00370	Dihydrolipoyl dehydrogenase. (516 aa)
	PV10_06916	TauD domain-containing protein. (598 aa)
	PV10_07297	Post-SET domain-containing protein. (182 aa)
	PV10_01490	Uncharacterized protein. (1112 aa)
	PV10_00999	Uncharacterized protein. (870 aa)
	PV10_01111	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
	PV10_01140	Uncharacterized protein. (590 aa)
	PV10_07810	Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (967 aa)
	PV10_01936	Uncharacterized protein. (514 aa)
	PV10_06149	PHD domain-containing protein. (564 aa)
	PV10_06260	TauD domain-containing protein. (412 aa)
	PV10_04172	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (533 aa)
	PV10_04253	Zn(2)-C6 fungal-type domain-containing protein. (844 aa)
	PV10_04589	Uncharacterized protein. (448 aa)
	PV10_04765	MHYT domain-containing protein. (840 aa)
	PV10_02520	Uncharacterized protein. (881 aa)
	PV10_02864	Trimethyllysine dioxygenase. (517 aa)
	PV10_02970	Histone-lysine N-methyltransferase, H3 lysine-4 specific. (1415 aa)
	PV10_03158	Uncharacterized protein. (426 aa)
	PV10_00629	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (461 aa)
	PV10_00721	Aldedh domain-containing protein. (496 aa)
	PV10_01277	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (531 aa)
	PV10_00856	Uncharacterized protein. (732 aa)
	PV10_01353	DAO domain-containing protein. (458 aa)
	PV10_09224	Uncharacterized protein. (205 aa)
	PV10_07943	Uncharacterized protein. (412 aa)
	PV10_06258	F-box domain-containing protein. (460 aa)
	PV10_03900	Zn(2)-C6 fungal-type domain-containing protein. (832 aa)
	PV10_05203	Uncharacterized protein. (535 aa)
	PV10_02025	DAO domain-containing protein. (436 aa)
	PV10_02738	Zn(2)-C6 fungal-type domain-containing protein. (383 aa)
	PV10_02913	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (437 aa)
	PV10_03071	SET domain-containing protein. (899 aa)
	PV10_00479	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family. (375 aa)
	PV10_01330	Uncharacterized protein. (237 aa)
	PV10_09221	SET domain-containing protein. (210 aa)
	PV10_09043	Uncharacterized protein. (979 aa)
	PV10_09129	Uncharacterized protein. (815 aa)
	PV10_08693	Protein kinase domain-containing protein. (926 aa)
	PV10_08271	Zn(2)-C6 fungal-type domain-containing protein. (692 aa)
	PV10_08719	Uncharacterized protein. (537 aa)
	PV10_08935	Aldedh domain-containing protein. (511 aa)
	PV10_05380	Homoserine O-acetyltransferase. (532 aa)
	PV10_05450	AB hydrolase-1 domain-containing protein. (585 aa)
	PV10_07436	Zn(2)-C6 fungal-type domain-containing protein. (667 aa)
	PV10_05694	Uncharacterized protein. (53 aa)
	PV10_06145	Uncharacterized protein. (371 aa)
	PV10_05738	Pyr_redox_2 domain-containing protein. (138 aa)
	PV10_06784	Uncharacterized protein. (579 aa)
	PV10_03732	Fibronectin type-III domain-containing protein. (1126 aa)
	PV10_06227	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	PV10_03813	Uncharacterized protein. (373 aa)
	PV10_03856	Uncharacterized protein. (344 aa)
	PV10_06601	Uncharacterized protein. (398 aa)
	PV10_03724	Aldedh domain-containing protein. (478 aa)
	PV10_04642	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (497 aa)
	PV10_04909	Uncharacterized protein. (402 aa)
	PV10_04932	SET domain-containing protein. (440 aa)
	PV10_02411	Succinate-semialdehyde dehydrogenase. (537 aa)
	PV10_02519	Uncharacterized protein. (572 aa)
	PV10_02028	Uncharacterized protein. (411 aa)
	PV10_02225	Uncharacterized protein. (1306 aa)
	PV10_02351	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (545 aa)
	PV10_02448	Uncharacterized protein. (392 aa)
	PV10_02482	Zn(2)-C6 fungal-type domain-containing protein. (631 aa)
	PV10_02693	Uncharacterized protein. (229 aa)
	PV10_02845	Uncharacterized protein. (145 aa)
	PV10_03508	PHD-type domain-containing protein. (590 aa)
	PV10_07945	Uncharacterized protein. (398 aa)
	PV10_00337	Lipoyl-binding domain-containing protein. (463 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV10_00337	PV10_00370	A0A0D1ZPF7	A0A0D1ZRG9	Lipoyl-binding domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.990
PV10_00337	PV10_00513	A0A0D1ZPF7	A0A0D1X4H2	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_00629	A0A0D1ZPF7	A0A0D2ACZ9	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_00721	A0A0D1ZPF7	A0A0D2ADC6	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein.	0.429
PV10_00337	PV10_00760	A0A0D1ZPF7	A0A0D1X572	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_01111	A0A0D1ZPF7	A0A0D1ZTU2	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_01277	A0A0D1ZPF7	A0A0D2AF69	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_02351	A0A0D1ZPF7	A0A0D1ZL05	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_02411	A0A0D1ZPF7	A0A0D1ZJ77	Lipoyl-binding domain-containing protein.	Succinate-semialdehyde dehydrogenase.	0.429
PV10_00337	PV10_02519	A0A0D1ZPF7	A0A0D1ZJI0	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.719
PV10_00337	PV10_02520	A0A0D1ZPF7	A0A0D2A6X9	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.559
PV10_00337	PV10_02913	A0A0D1ZPF7	A0A0D1Y3K8	Lipoyl-binding domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.719
PV10_00337	PV10_03158	A0A0D1ZPF7	A0A0D2A998	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.846
PV10_00337	PV10_03724	A0A0D1ZPF7	A0A0D1ZEW6	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein.	0.512
PV10_00337	PV10_04253	A0A0D1ZPF7	A0A0D2A1X3	Lipoyl-binding domain-containing protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.429
PV10_00337	PV10_04491	A0A0D1ZPF7	A0A0D1WV98	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.479
PV10_00337	PV10_04642	A0A0D1ZPF7	A0A0D1ZHV3	Lipoyl-binding domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_04989	A0A0D1ZPF7	A0A0D1WWN0	Lipoyl-binding domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.429
PV10_00337	PV10_05203	A0A0D1ZPF7	A0A0D1Y0P3	Lipoyl-binding domain-containing protein.	Uncharacterized protein.	0.980
PV10_00337	PV10_05380	A0A0D1ZPF7	A0A0D1Z7G8	Lipoyl-binding domain-containing protein.	Homoserine O-acetyltransferase.	0.429