(77 nodes) Propanoate metabolism network (Exophiala mesophila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV10_04428	Uncharacterized protein. (196 aa)
	PV10_09228	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (300 aa)
	PV10_09113	SET domain-containing protein. (540 aa)
	PV10_08004	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (323 aa)
	PV10_08095	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (697 aa)
	PV10_06859	Epimerase domain-containing protein. (368 aa)
	PV10_05292	Transket_pyr domain-containing protein. (391 aa)
	PV10_05318	2-methylcitrate dehydratase. (556 aa)
	PV10_05981	Uncharacterized protein. (288 aa)
	PV10_06678	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (455 aa)
	PV10_05120	Uncharacterized protein. (391 aa)
	PV10_05138	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (282 aa)
	B0A52_04646	Uncharacterized protein. (366 aa)
	PV10_01284	Helicase ATP-binding domain-containing protein. (470 aa)
	PV10_01550	CoA carboxyltransferase C-terminal domain-containing protein. (693 aa)
	PV10_01576	Uncharacterized protein. (318 aa)
	PV10_01713	Uncharacterized protein. (315 aa)
	PV10_08005	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (473 aa)
	PV10_08037	CoA_binding domain-containing protein. (704 aa)
	PV10_07569	Epimerase domain-containing protein. (344 aa)
	PV10_07615	Uncharacterized protein. (2288 aa)
	PV10_05554	Uncharacterized protein. (760 aa)
	PV10_05802	Epimerase domain-containing protein. (346 aa)
	PV10_06250	Uncharacterized protein. (335 aa)
	PV10_03848	Uncharacterized protein. (330 aa)
	PV10_04394	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (468 aa)
	PV10_05450	AB hydrolase-1 domain-containing protein. (585 aa)
	PV10_07371	Epimerase domain-containing protein. (328 aa)
	PV10_05327	Epimerase domain-containing protein. (389 aa)
	PV10_06234	NAD(P)-bd_dom domain-containing protein. (348 aa)
	PV10_05730	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (521 aa)
	PV10_05738	Pyr_redox_2 domain-containing protein. (138 aa)
	PV10_05772	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa)
	PV10_06227	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (413 aa)
	PV10_06431	Uncharacterized protein. (311 aa)
	PV10_04021	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (283 aa)
	B0A52_05626	Uncharacterized protein. (221 aa)
	PV10_04723	Uncharacterized protein. (387 aa)
	PV10_04867	Uncharacterized protein. (318 aa)
	PV10_04948	3-hydroxyisobutyrate dehydrogenase. (336 aa)
	PV10_04318	Probable acetate kinase. (414 aa)
	PV10_04468	Uncharacterized protein. (375 aa)
	PV10_02519	Uncharacterized protein. (572 aa)
	PV10_08209	Pyr_redox_2 domain-containing protein. (347 aa)
	PV10_00139	Uncharacterized protein. (333 aa)
	PV10_00944	Uncharacterized protein. (481 aa)
	PV10_00370	Dihydrolipoyl dehydrogenase. (516 aa)
	PV10_00769	Epimerase domain-containing protein. (342 aa)
	PV10_01467	PLD phosphodiesterase domain-containing protein. (651 aa)
	PV10_01283	SEC63 domain-containing protein. (615 aa)
	PV10_01883	Uncharacterized protein. (714 aa)
	PV10_03777	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (521 aa)
	PV10_04485	Epimerase domain-containing protein. (357 aa)
	PV10_02520	Uncharacterized protein. (881 aa)
	PV10_03131	Epimerase domain-containing protein. (343 aa)
	PV10_00645	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (698 aa)
	PV10_01411	SET domain-containing protein. (485 aa)
	PV10_01838	Acetyl-coenzyme A synthetase. (670 aa)
	PV10_04563	Methylmalonate-semialdehyde dehydrogenase (Acylating). (544 aa)
	PV10_05203	Uncharacterized protein. (535 aa)
	PV10_02617	Uncharacterized protein. (316 aa)
	PV10_02812	Epimerase domain-containing protein. (372 aa)
	PV10_02817	Uncharacterized protein. (335 aa)
	PV10_02913	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (437 aa)
	PV10_03518	Uncharacterized protein. (334 aa)
	PV10_00695	Uncharacterized protein. (357 aa)
	PV10_00719	PKS_ER domain-containing protein. (349 aa)
	PV10_00766	Epimerase domain-containing protein. (346 aa)
	PV10_09056	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (330 aa)
	PV10_07991	Epimerase domain-containing protein. (363 aa)
	PV10_08132	Methylmalonate-semialdehyde dehydrogenase (Acylating). (570 aa)
	PV10_06842	Uncharacterized protein. (480 aa)
	PV10_07077	Peroxisomal hydratase-dehydrogenase-epimerase. (901 aa)
	PV10_07458	Uncharacterized protein. (2044 aa)
	PV10_07701	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (445 aa)
	PV10_07778	Transket_pyr domain-containing protein. (389 aa)
	PV10_07843	Uncharacterized protein. (355 aa)

Your Current Organism:

Exophiala mesophila

NCBI taxonomy Id: 212818
Other names: CBS 402.95, E. mesophila

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A52_05626	PV10_03848	A0A0D1ZFD3	A0A0D1XWJ4	Uncharacterized protein.	Uncharacterized protein.	0.425
PV10_00139	PV10_00645	A0A0D1ZQI3	A0A0D2AD18	Uncharacterized protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.572
PV10_00139	PV10_01550	A0A0D1ZQI3	A0A0D1X7K7	Uncharacterized protein.	CoA carboxyltransferase C-terminal domain-containing protein.	0.600
PV10_00139	PV10_01576	A0A0D1ZQI3	A0A0D1X7N4	Uncharacterized protein.	Uncharacterized protein.	0.431
PV10_00139	PV10_02617	A0A0D1ZQI3	A0A0D1Y2S8	Uncharacterized protein.	Uncharacterized protein.	0.431
PV10_00139	PV10_03777	A0A0D1ZQI3	A0A0D2A0C0	Uncharacterized protein.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.890
PV10_00139	PV10_04021	A0A0D1ZQI3	A0A0D1ZDG8	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.431
PV10_00139	PV10_04394	A0A0D1ZQI3	A0A0D1XY46	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.523
PV10_00139	PV10_04428	A0A0D1ZQI3	A0A0D1XY79	Uncharacterized protein.	Uncharacterized protein.	0.431
PV10_00139	PV10_04563	A0A0D1ZQI3	A0A0D1XYL9	Uncharacterized protein.	Methylmalonate-semialdehyde dehydrogenase (Acylating).	0.720
PV10_00139	PV10_04867	A0A0D1ZQI3	A0A0D1ZG59	Uncharacterized protein.	Uncharacterized protein.	0.431
PV10_00139	PV10_05138	A0A0D1ZQI3	A0A0D1WX60	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.431
PV10_00139	PV10_05730	A0A0D1ZQI3	A0A0D1ZAZ7	Uncharacterized protein.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.696
PV10_00139	PV10_05772	A0A0D1ZQI3	A0A0D1ZB48	Uncharacterized protein.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.477
PV10_00139	PV10_05981	A0A0D1ZQI3	A0A0D1WQS4	Uncharacterized protein.	Uncharacterized protein.	0.431
PV10_00139	PV10_08004	A0A0D1ZQI3	A0A0D1WHK9	Uncharacterized protein.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.446
PV10_00139	PV10_08005	A0A0D1ZQI3	A0A0D1XJE2	Uncharacterized protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.727
PV10_00139	PV10_08095	A0A0D1ZQI3	A0A0D1WHW6	Uncharacterized protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.572
PV10_00139	PV10_08132	A0A0D1ZQI3	A0A0D1Z3I2	Uncharacterized protein.	Methylmalonate-semialdehyde dehydrogenase (Acylating).	0.853
PV10_00139	PV10_08209	A0A0D1ZQI3	A0A0D1ZP67	Uncharacterized protein.	Pyr_redox_2 domain-containing protein.	0.720