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mfnB mfnB AKB63386.1 AKB63386.1 AKB63596.1 AKB63596.1 AKB63766.1 AKB63766.1 AKB63819.1 AKB63819.1 cdhE cdhE cdhD cdhD AKB63823.1 AKB63823.1 cdhC cdhC cdhB cdhB cdhA cdhA AKB63878.1 AKB63878.1 AKB64060.1 AKB64060.1 AKB64092.1 AKB64092.1 AKB64407.1 AKB64407.1 AKB64408.1 AKB64408.1 AKB64416.1 AKB64416.1 AKB64464.1 AKB64464.1 AKB64465.1 AKB64465.1 AKB64466.1 AKB64466.1 AKB64469.1 AKB64469.1 AKB65120.1 AKB65120.1 mch mch AKB65336.1 AKB65336.1 AKB65387.1 AKB65387.1 AKB65388.1 AKB65388.1 AKB65389.1 AKB65389.1 AKB65595.1 AKB65595.1 AKB65659.1 AKB65659.1 AKB65789.1 AKB65789.1 cdhA-2 cdhA-2 cdhB-2 cdhB-2 cdhC-2 cdhC-2 AKB65795.1 AKB65795.1 AKB65796.1 AKB65796.1 cdhE-2 cdhE-2 AKB65895.1 AKB65895.1 AKB65896.1 AKB65896.1 AKB65897.1 AKB65897.1 AKB65898.1 AKB65898.1 AKB66026.1 AKB66026.1 AKB66027.1 AKB66027.1 AKB66028.1 AKB66028.1 AKB66029.1 AKB66029.1 AKB66053.1 AKB66053.1 AKB66079.1 AKB66079.1 AKB66273.1 AKB66273.1 AKB66295.1 AKB66295.1 AKB66296.1 AKB66296.1 AKB66297.1 AKB66297.1 AKB66298.1 AKB66298.1 AKB66299.1 AKB66299.1 AKB66300.1 AKB66300.1 ftr ftr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mfnBDuf556 family protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (234 aa)
AKB63386.1Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family. (233 aa)
AKB63596.1Beta-ribofuranosylaminobenzene 5'-phosphate synthase; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (307 aa)
AKB63766.1Threonine dehydrogenase and related Zn-dependent dehydrogenase. (446 aa)
AKB63819.1Hypothetical protein. (399 aa)
cdhE5-tetrahydromethanopterin:corrinoid iron-sulfur protein methyltransferase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. (470 aa)
cdhDCO dehydrogenase/acetyl-CoA synthase subunit delta, corrinoid iron-sulfur subcomplex small subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex. (436 aa)
AKB63823.1CO dehydrogenase accessory protein CooC (nickel insertion). (264 aa)
cdhCCO dehydrogenase/acetyl-CoA synthase subunit beta, acetyl-CoA synthase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex). (469 aa)
cdhBCO dehydrogenase/acetyl-CoA synthase subunit epsilon, CO dehydrogenase subcomplex; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation. (170 aa)
cdhACO dehydrogenase/acetyl-CoA synthase subunit alpha, CO dehydrogenase subcomplex; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (807 aa)
AKB63878.1Coenzyme F420 hydrogenase subunit beta. (346 aa)
AKB64060.1Zinc-finger protein. (204 aa)
AKB64092.1CoB--CoM heterodisulfide reductase subunit B. (100 aa)
AKB64407.1CO dehydrogenase iron-sulfur protein CooF. (180 aa)
AKB64408.1Carbon monoxide dehydrogenase CooS subunit. (624 aa)
AKB64416.1Tetrahydromethanopterin:alpha-L-glutamate ligase. (324 aa)
AKB64464.1Formylmethanofuran dehydrogenase subunit D. (132 aa)
AKB64465.1Formylmethanofuran dehydrogenase subunit B. (414 aa)
AKB64466.1Tungsten-containing formylmethanofuran dehydrogenase 2 subunit G. (150 aa)
AKB64469.1Polyferredoxin protein MvhB. (500 aa)
AKB65120.1Nickel insertion protein. (221 aa)
mchN(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (321 aa)
AKB65336.1Nickel insertion protein. (254 aa)
AKB65387.1Delta 1-pyrroline-5-carboxylate synthetase. (230 aa)
AKB65388.1Putative H4MPT-linked C1 transfer pathway protein. (327 aa)
AKB65389.1COG1821 family protein. (325 aa)
AKB65595.1acetyl-CoA decarbonylase/synthase complex subunit alpha. (634 aa)
AKB65659.1DNA polymerase, beta-like region. (313 aa)
AKB65789.1Nickel insertion protein. (272 aa)
cdhA-2CO dehydrogenase/acetyl-CoA synthase subunit alpha, CO dehydrogenase subcomplex; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (806 aa)
cdhB-2CO dehydrogenase/acetyl-CoA synthase subunit epsilon, CO dehydrogenase subcomplex; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation. (170 aa)
cdhC-2CO dehydrogenase/acetyl-CoA synthase subunit beta, acetyl-CoA synthase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex). (460 aa)
AKB65795.1CO dehydrogenase accessory protein CooC (nickel insertion). (253 aa)
AKB65796.1CO dehydrogenase/acetyl-CoA synthase subunit delta, corrinoid iron-sulfur subcomplex small subunit. (436 aa)
cdhE-25-tetrahydromethanopterin:corrinoid iron-sulfur protein methyltransferase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. (470 aa)
AKB65895.1Formylmethanofuran dehydrogenase (tungsten) subunit D. (127 aa)
AKB65896.1Formylmethanofuran dehydrogenase subunit B. (450 aa)
AKB65897.1Formylmethanofuran dehydrogenase subunit A. (572 aa)
AKB65898.1Formylmethanofuran dehydrogenase subunit C. (252 aa)
AKB66026.1Indolepyruvate oxidoreductase subunit IorA. (239 aa)
AKB66027.1DUF447 family protein. (212 aa)
AKB66028.1Triphosphoribosyl-dephospho-CoA synthetase. (351 aa)
AKB66029.1tRNA-dihydrouridine synthase C. (379 aa)
AKB66053.1Ferredoxin. (87 aa)
AKB66079.1Valine--pyruvate aminotransferase. (394 aa)
AKB66273.1Beta-ribofuranosylaminobenzene 5'-phosphate synthase; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P). (323 aa)
AKB66295.1Formylmethanofuran dehydrogenase (molybdenum) subunit B. (433 aa)
AKB66296.1Formylmethanofuran dehydrogenase (molybdenum) subunit D. (129 aa)
AKB66297.1Formylmethanofuran dehydrogenase (molybdenum) subunit C. (288 aa)
AKB66298.1Formylmethanofuran dehydrogenase subunit A. (584 aa)
AKB66299.1Polyferredoxin protein MvhB. (340 aa)
AKB66300.1FmdE, Molybdenum formylmethanofuran dehydrogenase operon. (189 aa)
ftrFormylmethanofuran--tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa)
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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