STRINGSTRING
AKB63224.1 AKB63224.1 AKB63226.1 AKB63226.1 AKB63227.1 AKB63227.1 AKB63449.1 AKB63449.1 AKB63456.1 AKB63456.1 AKB63457.1 AKB63457.1 AKB63458.1 AKB63458.1 AKB63459.1 AKB63459.1 AKB63461.1 AKB63461.1 AKB63462.1 AKB63462.1 AKB63463.1 AKB63463.1 AKB63481.1 AKB63481.1 cbiT cbiT AKB63497.1 AKB63497.1 AKB63498.1 AKB63498.1 AKB63499.1 AKB63499.1 AKB63500.1 AKB63500.1 AKB63501.1 AKB63501.1 AKB63502.1 AKB63502.1 AKB63522.1 AKB63522.1 AKB63539.1 AKB63539.1 AKB63540.1 AKB63540.1 AKB63541.1 AKB63541.1 AKB63542.1 AKB63542.1 AKB63543.1 AKB63543.1 AKB63544.1 AKB63544.1 AKB63580.1 AKB63580.1 AKB63606.1 AKB63606.1 AKB63607.1 AKB63607.1 AKB63614.1 AKB63614.1 AKB63615.1 AKB63615.1 AKB63671.1 AKB63671.1 AKB63672.1 AKB63672.1 AKB63755.1 AKB63755.1 AKB63757.1 AKB63757.1 AKB63779.1 AKB63779.1 AKB63780.1 AKB63780.1 AKB63781.1 AKB63781.1 AKB63784.1 AKB63784.1 AKB63785.1 AKB63785.1 AKB63786.1 AKB63786.1 AKB63787.1 AKB63787.1 AKB63788.1 AKB63788.1 AKB63789.1 AKB63789.1 AKB63790.1 AKB63790.1 AKB63791.1 AKB63791.1 AKB63792.1 AKB63792.1 AKB63793.1 AKB63793.1 nifH nifH AKB63801.1 AKB63801.1 cbiX cbiX AKB63987.1 AKB63987.1 AKB63988.1 AKB63988.1 cbiA cbiA cbiM cbiM cbiN cbiN AKB64037.1 AKB64037.1 AKB64038.1 AKB64038.1 AKB64187.1 AKB64187.1 AKB64188.1 AKB64188.1 AKB64189.1 AKB64189.1 AKB64272.1 AKB64272.1 AKB64282.1 AKB64282.1 AKB64324.1 AKB64324.1 cobQ cobQ AKB64481.1 AKB64481.1 AKB64552.1 AKB64552.1 AKB64553.1 AKB64553.1 AKB64676.1 AKB64676.1 AKB64741.1 AKB64741.1 AKB64860.1 AKB64860.1 AKB64861.1 AKB64861.1 AKB64889.1 AKB64889.1 AKB64890.1 AKB64890.1 mobA mobA AKB65131.1 AKB65131.1 AKB65255.1 AKB65255.1 AKB65256.1 AKB65256.1 AKB65324.1 AKB65324.1 AKB65325.1 AKB65325.1 AKB65326.1 AKB65326.1 AKB65327.1 AKB65327.1 AKB65328.1 AKB65328.1 AKB65329.1 AKB65329.1 AKB65429.1 AKB65429.1 AKB65480.1 AKB65480.1 AKB65481.1 AKB65481.1 AKB65506.1 AKB65506.1 AKB65507.1 AKB65507.1 AKB65508.1 AKB65508.1 moaC moaC AKB65813.1 AKB65813.1 AKB65814.1 AKB65814.1 AKB65815.1 AKB65815.1 AKB65822.1 AKB65822.1 cobD cobD AKB65824.1 AKB65824.1 cobS cobS AKB65826.1 AKB65826.1 AKB65829.1 AKB65829.1 AKB65873.1 AKB65873.1 AKB65878.1 AKB65878.1 AKB65880.1 AKB65880.1 AKB65881.1 AKB65881.1 AKB65918.1 AKB65918.1 AKB65919.1 AKB65919.1 AKB65920.1 AKB65920.1 hemC hemC hemL hemL AKB66133.1 AKB66133.1 hemA hemA AKB66135.1 AKB66135.1 AKB66136.1 AKB66136.1 AKB66137.1 AKB66137.1 AKB66138.1 AKB66138.1 AKB66142.1 AKB66142.1 AKB66143.1 AKB66143.1 AKB66144.1 AKB66144.1 AKB66145.1 AKB66145.1 cbiD cbiD AKB66189.1 AKB66189.1 AKB66261.1 AKB66261.1 AKB66262.1 AKB66262.1 AKB66263.1 AKB66263.1 AKB66264.1 AKB66264.1 AKB66267.1 AKB66267.1 AKB66268.1 AKB66268.1 AKB66269.1 AKB66269.1 AKB66285.1 AKB66285.1 AKB66286.1 AKB66286.1 AKB66287.1 AKB66287.1 AKB66289.1 AKB66289.1 AKB66301.1 AKB66301.1 AKB66302.1 AKB66302.1 AKB66303.1 AKB66303.1 AKB66314.1 AKB66314.1 AKB66331.1 AKB66331.1 fdhD fdhD AKB66385.1 AKB66385.1 AKB66389.1 AKB66389.1 cbiA-2 cbiA-2 moaA moaA AKB66523.1 AKB66523.1 AKB66524.1 AKB66524.1 AKB66525.1 AKB66525.1 AKB66526.1 AKB66526.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKB63224.1Fe-S OXIDOREDUCTASE. (711 aa)
AKB63226.1Putative deoxyribonuclease YcfH. (257 aa)
AKB63227.1Hypothetical protein. (66 aa)
AKB63449.1Molybdopterin biosynthesis protein MoeA; Periplasmic molybdate-binding domain. (644 aa)
AKB63456.1Transmembrane component BioN of energizing module of biotin ECF transporter. (257 aa)
AKB63457.1ATPase component BioM of energizing module of biotin ECF transporter. (287 aa)
AKB63458.1ATPase component BioM of energizing module of biotin ECF transporter. (274 aa)
AKB63459.1Substrate-specific component BioY of biotin ECF transporter. (187 aa)
AKB63461.1Iron-dependent repressor IdeR/DtxR. (217 aa)
AKB63462.1Ferrous iron transport protein B. (665 aa)
AKB63463.1Hypothetical protein. (64 aa)
AKB63481.1Radical SAM domain protein. (377 aa)
cbiTCobalt-precorrin-6y C15-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (184 aa)
AKB63497.1Cobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (202 aa)
AKB63498.1Cobalt-precorrin-4 C11-methyltransferase. (242 aa)
AKB63499.1Cobalamin biosynthesis protein CbiG. (130 aa)
AKB63500.1Cobalamin biosynthesis protein CbiG. (117 aa)
AKB63501.1Cobalt-precorrin-3b C17-methyltransferase. (265 aa)
AKB63502.1Cobalt-precorrin-8x methylmutase. (243 aa)
AKB63522.1Hypothetical protein. (401 aa)
AKB63539.1Hypothetical protein. (75 aa)
AKB63540.1Putative small heat shock protein. (102 aa)
AKB63541.1Putative small heat shock protein. (99 aa)
AKB63542.1Hypothetical protein. (142 aa)
AKB63543.1Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (115 aa)
AKB63544.1Ammonium transporter. (469 aa)
AKB63580.1Aldehyde ferredoxin oxidoreductase. (577 aa)
AKB63606.1Additional substrate-specific component NikN of nickel ECF transporter. (101 aa)
AKB63607.1Substrate-specific component NikM of nickel ECF transporter. (221 aa)
AKB63614.1Transmembrane component NikQ of energizing module of nickel ECF transporter. (268 aa)
AKB63615.1ATPase component NikO of energizing module of nickel ECF transporter; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (327 aa)
AKB63671.1Molybdopterin converting factor small subunit. (97 aa)
AKB63672.1Molybdopterin biosynthesis MoeA protein. (396 aa)
AKB63755.1Nitrogenase FeMo-cofactor synthesis FeS core scaffold and assembly protein NifB. (315 aa)
AKB63757.1Nitrogenase FeMo-cofactor synthesis FeS core scaffold and assembly protein NifB. (328 aa)
AKB63779.1Hypothetical protein. (88 aa)
AKB63780.1Ammonium transporter. (397 aa)
AKB63781.1Nitrogen regulatory protein P-II. (114 aa)
AKB63784.1ABC transporter. (304 aa)
AKB63785.1Molybdenum transport ATP-binding protein ModC; TCDB 3.A.1.8.1. (88 aa)
AKB63786.1Molybdenum transport system permease protein ModB; TCDB 3.A.1.8.1. (221 aa)
AKB63787.1Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA; TCDB 3.A.1.8.1. (272 aa)
AKB63788.1Nitrogenase FeMo-cofactor scaffold and assembly protein NifN. (526 aa)
AKB63789.1Nitrogenase FeMo-cofactor scaffold and assembly protein NifE; Belongs to the NifD/NifK/NifE/NifN family. (535 aa)
AKB63790.1Nitrogenase (molybdenum-iron) beta chain; This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation; Belongs to the NifD/NifK/NifE/NifN family. (456 aa)
AKB63791.1Nitrogenase (molybdenum-iron) alpha chain. (532 aa)
AKB63792.1Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (125 aa)
AKB63793.1Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. (105 aa)
nifHNitrogenase (molybdenum-iron) reductase and maturation protein NifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (273 aa)
AKB63801.1Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. (349 aa)
cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (130 aa)
AKB63987.1Nitrogenase-related protein. (370 aa)
AKB63988.1Nitrogenase reductase-like protein. (265 aa)
cbiACobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (498 aa)
cbiMSubstrate-specific component CbiM of cobalt ECF transporter; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (232 aa)
cbiNAdditional substrate-specific component CbiN of cobalt ECF transporter; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (113 aa)
AKB64037.1Transmembrane component CbiQ of energizing module of cobalt ECF transporter. (260 aa)
AKB64038.1ATPase component CbiO of energizing module of cobalt ECF transporter; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (453 aa)
AKB64187.1Radical SAM domain protein. (399 aa)
AKB64188.1Uroporphyrinogen-III synthase. (263 aa)
AKB64189.1Uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. (255 aa)
AKB64272.1Molybdate-binding domain of ModE. (69 aa)
AKB64282.1Hypothetical protein. (461 aa)
AKB64324.1Adenosylcobinamide amidohydrolase. (200 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (488 aa)
AKB64481.1Hypothetical protein. (879 aa)
AKB64552.1Iron-sulfur cluster binding protein. (172 aa)
AKB64553.1Tungsten-containing aldehyde:ferredoxin oxidoreductase. (588 aa)
AKB64676.1Transcriptional regulator, ArsR family. (137 aa)
AKB64741.1Cob(I)alamin adenosyltransferase. (173 aa)
AKB64860.1Transmembrane component of general energizing module of ECF transporters. (287 aa)
AKB64861.1ATPase component of general energizing module of ECF transporters. (590 aa)
AKB64889.1Rubisco activation protein CbbQ. (276 aa)
AKB64890.1Hypothetical protein. (1379 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (224 aa)
AKB65131.1Molybdopterin-guanine dinucleotide biosynthesis protein MobB. (278 aa)
AKB65255.1Tungsten-containing aldehyde:ferredoxin oxidoreductase. (608 aa)
AKB65256.1Molybdenum cofactor biosynthesis protein MoaD. (100 aa)
AKB65324.1Ferrous iron transport protein A. (82 aa)
AKB65325.1Ferrous iron transport protein A. (84 aa)
AKB65326.1Ferrous iron transport protein B. (665 aa)
AKB65327.1Hypothetical protein. (152 aa)
AKB65328.1Hypothetical protein. (103 aa)
AKB65329.1Iron-dependent repressor IdeR/DtxR. (161 aa)
AKB65429.1Radical SAM domain protein. (206 aa)
AKB65480.1Transcriptional regulator, AsnC family. (70 aa)
AKB65481.1Hypothetical protein. (81 aa)
AKB65506.1Transmembrane component of energizing module of predicted tryptophan ECF transporter. (262 aa)
AKB65507.1Duplicated ATPase component of energizing module of predicted tryptophan ECF transporter. (498 aa)
AKB65508.1Substrate-specific component TrpP of tryptophan ECF transporter. (174 aa)
moaCMolybdenum cofactor biosynthesis enzyme; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (157 aa)
AKB65813.1Iron(III) dicitrate-binding protein. (404 aa)
AKB65814.1Iron(III) dicitrate transport system permease protein. (356 aa)
AKB65815.1Iron(III) dicitrate transport ATP-binding protein. (269 aa)
AKB65822.1L-threonine 3-O-phosphate decarboxylase. (496 aa)
cobDAdenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (328 aa)
AKB65824.1Putative alpha-ribazole-5'-phosphate phosphatase CobZ. (180 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (280 aa)
AKB65826.1Putative adenosylcobinamide-phosphate guanylyltransferase CobY. (203 aa)
AKB65829.1Hypothetical protein. (120 aa)
AKB65873.1ChlD component of cobalt chelatase involved in B12 biosynthesis. (692 aa)
AKB65878.1CobN component of cobalt chelatase involved in B12 biosynthesis. (1304 aa)
AKB65880.1ATPase component of general energizing module of ECF transporters. (581 aa)
AKB65881.1Transmembrane component of general energizing module of ECF transporters. (297 aa)
AKB65918.1Hypothetical protein. (115 aa)
AKB65919.1Hypothetical protein. (103 aa)
AKB65920.1Purine nucleoside phosphoramidase. (151 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (316 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (424 aa)
AKB66133.1Porphobilinogen synthase; Belongs to the ALAD family. (324 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (448 aa)
AKB66135.1Siroheme synthase; Precorrin-2 oxidase; Sirohydrochlorin ferrochelatase. (223 aa)
AKB66136.1Heme biosynthesis protein related to NirL and NirH. (152 aa)
AKB66137.1Heme biosynthesis protein related to NirD and NirG. (182 aa)
AKB66138.1Radical SAM domain heme biosynthesis protein. (349 aa)
AKB66142.1Hypothetical protein. (112 aa)
AKB66143.1Heme biosynthesis protein related to NirL and NirH. (152 aa)
AKB66144.1Heme biosynthesis protein related to NirD and NirG. (187 aa)
AKB66145.1Radical SAM domain heme biosynthesis protein. (355 aa)
cbiDCobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (339 aa)
AKB66189.1Cobalt-precorrin-6y C5-methyltransferase. (207 aa)
AKB66261.1Hypothetical protein. (170 aa)
AKB66262.1S-adenosyl-L-methionine-binding protein. (145 aa)
AKB66263.1CobN-like chelatase BtuS for metalloporphyrine salvage. (1517 aa)
AKB66264.1CobN-like chelatase BtuS for metalloporphyrine salvage. (1449 aa)
AKB66267.1Hypothetical protein. (135 aa)
AKB66268.1Putative transporter PduT for various metalloporphyrins. (207 aa)
AKB66269.1Hypothetical protein. (230 aa)
AKB66285.1Molybdenum ABC transporter, periplasmic molybdenum-binding protein ModA; TCDB 3.A.1.8.1. (272 aa)
AKB66286.1Tungstate ABC transporter, permease protein WtpB. (250 aa)
AKB66287.1Tungstate ABC transporter, ATP-binding protein WtpC. (353 aa)
AKB66289.1Molybdenum ABC transporter ATP-binding protein. (281 aa)
AKB66301.1ABC-type tungstate transport system, ATP-binding protein. (353 aa)
AKB66302.1ABC-type tungstate transport system, permease protein. (229 aa)
AKB66303.1ABC-type tungstate transport system, periplasmic binding protein. (308 aa)
AKB66314.1Molybdate-binding domain of ModE. (194 aa)
AKB66331.1Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (244 aa)
fdhDFormate dehydrogenase chain D; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family. (262 aa)
AKB66385.1Molybdenum cofactor biosynthesis protein MoaB. (179 aa)
AKB66389.1moaA/nifB/pqqE family protein. (404 aa)
cbiA-2Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (439 aa)
moaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (339 aa)
AKB66523.1Zinc ABC transporter, inner membrane permease protein ZnuB. (274 aa)
AKB66524.1Zinc ABC transporter, ATP-binding protein ZnuC. (254 aa)
AKB66525.1Zinc ABC transporter, periplasmic-binding protein ZnuA. (328 aa)
AKB66526.1Putative zinc-dependent repressor ZntR, DtxR superfamily. (149 aa)
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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