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cbiT cbiT AKB63497.1 AKB63497.1 AKB63498.1 AKB63498.1 AKB63499.1 AKB63499.1 AKB63500.1 AKB63500.1 AKB63501.1 AKB63501.1 AKB63502.1 AKB63502.1 AKB63801.1 AKB63801.1 cbiX cbiX AKB64188.1 AKB64188.1 AKB64189.1 AKB64189.1 AKB64324.1 AKB64324.1 cobQ cobQ AKB64741.1 AKB64741.1 AKB64889.1 AKB64889.1 AKB64890.1 AKB64890.1 AKB65822.1 AKB65822.1 cobD cobD AKB65824.1 AKB65824.1 cobS cobS AKB65826.1 AKB65826.1 AKB65829.1 AKB65829.1 AKB65873.1 AKB65873.1 AKB65878.1 AKB65878.1 hemC hemC hemL hemL AKB66133.1 AKB66133.1 hemA hemA AKB66135.1 AKB66135.1 cbiD cbiD AKB66189.1 AKB66189.1 AKB66263.1 AKB66263.1 AKB66264.1 AKB66264.1 AKB66267.1 AKB66267.1 AKB66268.1 AKB66268.1 AKB66269.1 AKB66269.1 cbiA-2 cbiA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cbiTCobalt-precorrin-6y C15-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (184 aa)
AKB63497.1Cobalt-precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (202 aa)
AKB63498.1Cobalt-precorrin-4 C11-methyltransferase. (242 aa)
AKB63499.1Cobalamin biosynthesis protein CbiG. (130 aa)
AKB63500.1Cobalamin biosynthesis protein CbiG. (117 aa)
AKB63501.1Cobalt-precorrin-3b C17-methyltransferase. (265 aa)
AKB63502.1Cobalt-precorrin-8x methylmutase. (243 aa)
AKB63801.1Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family. (349 aa)
cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (130 aa)
AKB64188.1Uroporphyrinogen-III synthase. (263 aa)
AKB64189.1Uroporphyrinogen-III methyltransferase; Belongs to the precorrin methyltransferase family. (255 aa)
AKB64324.1Adenosylcobinamide amidohydrolase. (200 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (488 aa)
AKB64741.1Cob(I)alamin adenosyltransferase. (173 aa)
AKB64889.1Rubisco activation protein CbbQ. (276 aa)
AKB64890.1Hypothetical protein. (1379 aa)
AKB65822.1L-threonine 3-O-phosphate decarboxylase. (496 aa)
cobDAdenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (328 aa)
AKB65824.1Putative alpha-ribazole-5'-phosphate phosphatase CobZ. (180 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (280 aa)
AKB65826.1Putative adenosylcobinamide-phosphate guanylyltransferase CobY. (203 aa)
AKB65829.1Hypothetical protein. (120 aa)
AKB65873.1ChlD component of cobalt chelatase involved in B12 biosynthesis. (692 aa)
AKB65878.1CobN component of cobalt chelatase involved in B12 biosynthesis. (1304 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (316 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (424 aa)
AKB66133.1Porphobilinogen synthase; Belongs to the ALAD family. (324 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (448 aa)
AKB66135.1Siroheme synthase; Precorrin-2 oxidase; Sirohydrochlorin ferrochelatase. (223 aa)
cbiDCobalt-precorrin-6 synthase, anaerobic; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (339 aa)
AKB66189.1Cobalt-precorrin-6y C5-methyltransferase. (207 aa)
AKB66263.1CobN-like chelatase BtuS for metalloporphyrine salvage. (1517 aa)
AKB66264.1CobN-like chelatase BtuS for metalloporphyrine salvage. (1449 aa)
AKB66267.1Hypothetical protein. (135 aa)
AKB66268.1Putative transporter PduT for various metalloporphyrins. (207 aa)
AKB66269.1Hypothetical protein. (230 aa)
cbiA-2Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (439 aa)
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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