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AKB66487.1 AKB66487.1 AKB63200.1 AKB63200.1 tpiA tpiA AKB63314.1 AKB63314.1 AKB63333.1 AKB63333.1 AKB63366.1 AKB63366.1 AKB63386.1 AKB63386.1 AKB63502.1 AKB63502.1 AKB63568.1 AKB63568.1 gpmI gpmI AKB63776.1 AKB63776.1 AKB63814.1 AKB63814.1 ilvC ilvC AKB63849.1 AKB63849.1 AKB63966.1 AKB63966.1 AKB63996.1 AKB63996.1 AKB64116.1 AKB64116.1 AKB64117.1 AKB64117.1 AKB64118.1 AKB64118.1 glmM glmM AKB64312.1 AKB64312.1 truD truD rpiA rpiA trpF trpF topA topA gpmA gpmA AKB64962.1 AKB64962.1 AKB65093.1 AKB65093.1 trpF-2 trpF-2 AKB65246.1 AKB65246.1 pus10 pus10 gyrA gyrA gyrB gyrB top6A top6A top6B top6B AKB65528.1 AKB65528.1 AKB65534.1 AKB65534.1 AKB65642.1 AKB65642.1 nnrE nnrE truB truB purE purE AKB65909.1 AKB65909.1 fni fni hemL hemL AKB66230.1 AKB66230.1 AKB66259.1 AKB66259.1 AKB66316.1 AKB66316.1 AKB66342.1 AKB66342.1 hisA hisA truA truA apgM apgM AKB66488.1 AKB66488.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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AKB66487.1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (339 aa)
AKB63200.1Sugar phosphate isomerase/epimerase. (257 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa)
AKB63314.1UDP-glucose 4-epimerase. (298 aa)
AKB63333.1dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (183 aa)
AKB63366.1UDP-glucose 4-epimerase. (316 aa)
AKB63386.1Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family. (233 aa)
AKB63502.1Cobalt-precorrin-8x methylmutase. (243 aa)
AKB63568.1Lysine 2,3-aminomutase. (419 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (515 aa)
AKB63776.1Thiol-disulfide isomerase and thioredoxins; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. (77 aa)
AKB63814.1Beta-phosphoglucomutase. (226 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa)
AKB63849.1Mannose-1-phosphate guanylyltransferase (GDP); Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (435 aa)
AKB63966.1Mannose-6-phosphate isomerase. (132 aa)
AKB63996.1Mannose-6-phosphate isomerase. (121 aa)
AKB64116.1FKBP-type peptidyl-prolyl cis-trans isomerase SlyD. (160 aa)
AKB64117.1Peptidyl-prolyl cis-trans isomerase. (184 aa)
AKB64118.1Peptidyl-prolyl cis-trans isomerase. (160 aa)
glmMPhosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (444 aa)
AKB64312.1DNA topoisomerase I. (832 aa)
truDtRNA pseudouridine 13 synthase; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (438 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (234 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (253 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (752 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (241 aa)
AKB64962.1Mannose-6-phosphate isomerase, bifunctional enzyme. (426 aa)
AKB65093.1Peptidyl-prolyl cis-trans isomerase. (155 aa)
trpF-2Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (234 aa)
AKB65246.1Peptidyl-prolyl cis-trans isomerase. (247 aa)
pus10tRNA pseudouridine 55 synthase Archaea; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (431 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (950 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (634 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (369 aa)
top6BDNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (621 aa)
AKB65528.16-phospho-3-hexuloisomerase. (207 aa)
AKB65534.1Chorismate mutase I. (95 aa)
AKB65642.1Thiol-disulfide isomerase and thioredoxins; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. (76 aa)
nnrENAD(P)HX epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epime [...] (500 aa)
truBtRNA pseudouridine 55 synthase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (338 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa)
AKB65909.1Glucose-6-phosphate isomerase. (246 aa)
fniIsopentenyl-diphosphate delta-isomerase, FMN-dependent; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (365 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (424 aa)
AKB66230.1Beta-phosphoglucomutase. (218 aa)
AKB66259.1Ribose-1,5-bisphosphate isomerase; Belongs to the eIF-2B alpha/beta/delta subunits family. (307 aa)
AKB66316.1Sugar phosphate isomerase/epimerase. (269 aa)
AKB66342.1Phosphomannomutase; Belongs to the phosphohexose mutase family. (448 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (246 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (269 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (416 aa)
AKB66488.1Inositol-1-phosphate synthase. (366 aa)
Your Current Organism:
Methanosarcina mazei
NCBI taxonomy Id: 213585
Other names: M. mazei S-6, Methanosarcina mazei S-6
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