STRINGSTRING
spoT spoT gmk gmk pyrH pyrH ftsB ftsB dnaF dnaF b2065 b2065 nrdF nrdF nrdE nrdE nrdI nrdI nrdH nrdH ndk ndk adk adk pyrG pyrG YPO3378 YPO3378 YPO3379 YPO3379 relA relA nrdD nrdD nrdG nrdG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
spoTGuanosine-3',5'-bisbis(diphosphate) 3'-pyrophosphydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
ftsBSimilar to Escherichia coli ribonucleoside-diphosphate reductase 1 beta chain NrdB or FtsB SW:RIR2_ECOLI (P00453) (375 aa) fasta scores: E(): 0,88.3% id in 375 aa, and to Bacteriophage T4 ribonucleoside-diphosphate reductase beta chain NrdB SW:RIR2_BPT4 (P11156) (388 aa) fasta scores: E(): 0, 51.4% id in 385 aa. (376 aa)
dnaFRibonucleoside-diphosphate reductase 1 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (762 aa)
b2065Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)
nrdFRibonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
nrdERibonucleoside-diphosphate reductase 2 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (693 aa)
nrdINrdI protein homologue; Probably involved in ribonucleotide reductase function. (134 aa)
nrdHPutative glutaredoxin; Similar to Corynebacterium ammoniagenes NrdH-redoxin NrdH TR:O69271 (EMBL:Y09572) (75 aa) fasta scores: E(): 4.4e-14, 49.3% id in 75 aa, and to Mycobacterium tuberculosis hypothetical protein RV3053C TR:P95106 (EMBL:Z83866) (79 aa) fasta scores: E(): 2.9e-17, 54.7% id in 75 aa. (78 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
YPO3378Similar to Escherichia coli hypothetical protein MazG SW:MAZG_ECOLI (P33646) (263 aa) fasta scores: E(): 0,72.6% id in 266 aa, and to Vibrio cholerae MazG protein VC2450 TR:Q9KPC2 (EMBL:AE004315) (278 aa) fasta scores: E(): 0, 56.0% id in 268 aa. (280 aa)
YPO3379Hypothetical protein; No significant database hits. (52 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (744 aa)
nrdDSimilar to Escherichia coli anaerobic ribonucleoside-triphosphate reductase NrdD SW:NRDD_ECOLI (P28903) (712 aa) fasta scores: E(): 0, 86.0% id in 709 aa,and to Salmonella typhimurium anaerobic ribonucleoside-triphosphate reductase NrdD TR:Q9L646 (EMBL:AF242390) (712 aa) fasta scores: E(): 0, 87.2% id in 709 aa. (712 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (144 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.