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kmt kmt envZ envZ YPO0255 YPO0255 YPO0256 YPO0256 hmsT hmsT arcA arcA YPO0998 YPO0998 rcsC rcsC rcsB rcsB YPO1576 YPO1576 phoQ phoQ phoP phoP aer aer uvrY uvrY narR narR YPO2000 YPO2000 copR copR rssB rssB rstA rstA rstB rstB YPO2515 YPO2515 baeR baeR YPO2997 YPO2997 YPO2998 YPO2998 narP narP nmpB nmpB phoB phoB barA barA basR basR basS basS arcB arcB yhdA yhdA YPO3965 YPO3965 yhjK yhjK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kmtSimilar to Escherichia coli transcriptional regulatory protein OmpR SW:OMPR_ECOLI (P03025) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa and to Yersinia enterocolitica OmpR TR:P74982 (EMBL:Y08950) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa. (239 aa)
envZSimilar to Escherichia coli osmolarity sensor protein EnvZ SW:ENVZ_ECOLI (P02933) (450 aa) fasta scores: E(): 0, 86.6% id in 440 aa, and to Yersinia enterocolitica EnvZ TR:O06468 (EMBL:Y08950) (450 aa) fasta scores: E(): 0,93.8% id in 450 aa. (450 aa)
YPO0255Putative two-component response regulator; Similar to Salmonella typhimurium transcriptional activator SsrB TR:O54305 (EMBL:Z95891) (193 aa) fasta scores: E(): 0, 52.9% id in 189 aa, and to Pseudomonas aeruginosa response regulator GacA or Pa2586 TR:AAG05974 (EMBL:U27988) (214 aa) fasta scores: E(): 2.3e-22, 34.3% id in 207 aa. (210 aa)
YPO0256Two-component sensor/regulator; Similar to Salmonella typhimurium pathogenicity island regulator gene SpiR TR:P74862 (EMBL:U51927) (823 aa) fasta scores: E(): 0, 46.5% id in 826 aa and to Vibrio cholerae sensory box sensor histidine kinase/response regulator VieS VC1653 TR:Q9KRI8 (EMBL:AE004243) (1146 aa) fasta scores: E(): 0, 30.4% id in 559 aa. This CDS carries both the sensor and response regulator domains. (939 aa)
hmsTHmsT protein; Identical to the previously sequenced Yersinia pestis HmsT protein TR:Q9X5X6 (EMBL:AF129277) (390 aa) fasta scores: E(): 4.6e-148, 100.000% id in 390 aa. HmsT has been shown to be essential for the expression of the hemin storage (Hms+) phenotype. (390 aa)
arcASimilar to Escherichia coli aerobic respiration control protein ArcA SW:ARCA_ECOLI (P03026) (238 aa) fasta scores: E(): 0, 92.9% id in 238 aa, and to Vibrio cholerae aerobic respiration control protein FexA TR:Q9KPJ9 (EMBL:AE004307) (238 aa) fasta scores: E(): 0, 85.3% id in 238 aa. (238 aa)
YPO0998Putative membrane protein; Similar to Pseudomonas aeruginosa conserved hypothetical protein PA2072 TR:AAG05460 (EMBL:AE004634) (864 aa) fasta scores: E(): 0, 43.7% id in 773 aa, and to C-terminus of Pseudomonas aeruginosa conserved hypothetical protein PA4601 TR:AAG07989 (EMBL:AE004874) (1415 aa) fasta scores: E(): 0, 42.2% id in 460 aa. (788 aa)
rcsCTwo component sensor kinase/response regulator protein RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (957 aa)
rcsBProbable two component response regulator component B; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. (217 aa)
YPO1576Similar to Escherichia coli transcriptional regulatory protein UhpA SW:UHPA_ECOLI (P10940) (196 aa) fasta scores: E(): 0, 48.7% id in 197 aa, and to Salmonella typhimurium transcriptional regulatory protein UhpA SW:UHPA_SALTY (P27667) (196 aa) fasta scores: E(): 0, 48.5% id in 198 aa. (209 aa)
phoQSensor protein kinase; Similar to Escherichia coli membrane bound two component sensor protein PhoQ SW:PHOQ_ECOLI (P23837) (486 aa) fasta scores: E(): 0, 62.1% id in 478 aa, and to Salmonella typhimurium PhoQ protein TR:Q9L3L1 (EMBL:AJ272210) (487 aa) fasta scores: E(): 0, 62.4% id in 473 aa. (484 aa)
phoPResponse regulator protein; Similar to the previously sequenced Yersinia pestis PhoP protein TR:P74992 (EMBL:Y08758) (223 aa) fasta scores: E(): 0, 100.0% id in 223 aa, to Yersinia pseudotuberculosis PhoP protein TR:P74991 (EMBL:X66587) (223 aa) fasta scores: E(): 0, 99.1% id in 223 aa, to Yersinia enterocolitica PhoP protein TR:O87919 (EMBL:AJ011832) (200 aa) fasta scores: E(): 0, 98.5% id in 200 aa, and to Escherichia coli transcriptional regulatory protein PhoP SW:PHOP_ECOLI (P23836) (223 aa) fasta scores: E(): 0, 81.1% id in 222 aa. (223 aa)
aerPutative methyl-accepting chemotaxis protein; Similar to Escherichia coli aerotaxis receptor Aer or Air SW:AER_ECOLI (P50466) (506 aa) fasta scores: E(): 0,47.1% id in 514 aa, and to Escherichia coli methyl-accepting chemotaxis protein II Tar or CheM SW:MCP2_ECOLI (P07017) (553 aa) fasta scores: E(): 0, 43.3% id in 360 aa. (526 aa)
uvrYResponse regulator protein; Similar to Escherichia coli UvrY protein SW:UVRY_ECOLI (P07027) (218 aa) fasta scores: E(): 0, 82.9% id in 217 aa, and to Salmonella typhimurium SirA TR:P96058 (EMBL:U67869) (218 aa) fasta scores: E(): 0, 83.9% id in 217 aa. (218 aa)
narRNitrate/nitrite sensor protein; Previously sequenced as Yersinia pestis probable nitrate/nitrite sensor protein TR:Q9ZC64 (EMBL:AL031866) (593 aa) fasta scores: E(): 0, 100.0% id in 593 aa. Similar to Escherichia coli nitrate/nitrite sensor protein NarX SW:NARX_ECOLI (P10956) (598 aa) fasta scores: E(): 0, 47.9% id in 595 aa. (593 aa)
YPO2000Putative two-component system sensor protein; Member of a two-component regulatory system. (463 aa)
copRSimilar to Pseudomonas syringae transcriptional activator protein CopR SW:COPR_PSESM (Q02540) (227 aa) fasta scores: E(): 0, 60.8% id in 227 aa, and to Burkholderia pseudomallei transcriptional activator protein IrlR SW:IRLR_BURPS (O31395) (229 aa) fasta scores: E(): 0,57.6% id in 224 aa. (230 aa)
rssBProbable response regulator; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. (338 aa)
rstASimilar to Escherichia coli transcriptional regulatory protein RstA SW:RSTA_ECOLI (P52108) (242 aa) fasta scores: E(): 0, 73.9% id in 245 aa, and to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 1.3e-20, 33.5% id in 239 aa. (248 aa)
rstBTwo-component regulatory system, sensor kinase protein; Similar to Escherichia coli sensor protein RstB SW:RSTB_ECOLI (P18392) (433 aa) fasta scores: E(): 0, 69.5% id in 419 aa, and to Escherichia coli sensor protein CpxA SW:CPXA_ECOLI (P08336) (457 aa) fasta scores: E(): 2.5e-27,28.4% id in 450 aa. (425 aa)
YPO2515Putative chemotactic transducer; Similar to an internal region of Pseudomonas aeruginosa chemotactic transducer PctB TR:O32443 (EMBL:D86947) (629 aa) fasta scores: E(): 3.3e-14, 27.3% id in 395 aa, and to Campylobacter jejuni putative MCP-type signal transduction protein CJ1110C TR:Q9PNI4 (EMBL:AL139077) (429 aa) fasta scores: E(): 0, 36.4% id in 407 aa. The CDS appears to be truncated at the N-terminus in comparison to the Campylobacter jejuni protein and other homologues. Insertion of an IS100 element directly upstream has probably disrupted the promoter of this CDS. Effect on the fu [...] (415 aa)
baeRTwo-component system, sensor kinase (pseudogene); Pfam match to entry PF00512 signal, Histidine kinase, score -13.00, E-value 0.00023. (239 aa)
YPO2997Putative two-component system sensor kinase; Similar to Escherichia coli sensor protein BaeS SW:BAES_ECOLI (P30847) (467 aa) fasta scores: E(): 6.7e-19,26.3% id in 480 aa, and to Neisseria meningitidis sensor histidine kinase NMB0594 TR:Q9K0K1 (EMBL:AE002415) (468 aa) fasta scores: E(): 2.2e-31, 30.2% id in 463 aa. Probable histidine kinase protein of a two-component system. (449 aa)
YPO2998Putative two-component system response regulator; Similar to Escherichia coli transcriptional regulatory protein OmpR SW:OMPR_ECOLI (P03025) (239 aa) fasta scores: E(): 2.4e-29, 41.2% id in 226 aa, and to Neisseria meningitidis (serogroup A) putative two-component system regulator NMA0798 TR:Q9JRJ9 (EMBL:AL162754) (225 aa) fasta scores: E(): 0, 49.8% id in 223 aa. Probable response regulator protein of a two-component system. (227 aa)
narPSimilar to Escherichia coli nitrate/nitrite response regulator protein NarP SW:NARP_ECOLI (P31802) (215 aa) fasta scores: E(): 0, 67.6% id in 204 aa, and to Pasteurella multocida NarP TR:AAK03894 (EMBL:AE006218) (209 aa) fasta scores: E(): 0, 62.3% id in 207 aa. (209 aa)
nmpBSimilar to Escherichia coli phosphate regulon sensor protein PhoR or NmpB SW:PHOR_ECOLI (P08400) (431 aa) fasta scores: E(): 0, 73.2% id in 426 aa, and to Shigella dysenteriae phosphate regulon sensor protein PhoR SW:PHOR_SHIDY (P45609) (431 aa) fasta scores: E(): 0, 72.5% id in 426 aa. (438 aa)
phoBSimilar to Escherichia coli phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_ECOLI (P08402) (229 aa) fasta scores: E(): 0, 90.0% id in 229 aa,and to Shigella dysenteriae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_SHIDY (P45606) (229 aa) fasta scores: E(): 0, 89.5% id in 229 aa. (229 aa)
barATwo-component regulatory protein; Similar to Escherichia coli sensor protein BarA SW:BARA_ECOLI (P26607) (918 aa) fasta scores: E(): 0, 61.6% id in 928 aa, and to Erwinia carotovora subsp. carotovora sensor/regulator protein RpfA TR:O08235 (EMBL:U62023) (929 aa) fasta scores: E(): 0, 59.7% id in 938 aa. (930 aa)
basRTwo-component system response regulator; Similar to Escherichia coli transcriptional regulatory protein BasR or PmrA SW:BASR_ECOLI (P30843) (222 aa) fasta scores: E(): 0, 56.4% id in 218 aa, and to Salmonella typhimurium transcriptional regulatory protein BasR or PmrA SW:BASR_SALTY (P36556) (222 aa) fasta scores: E(): 0, 56.4% id in 218 aa. (220 aa)
basSSimilar to Escherichia coli sensor protein BasS or PmrB SW:BASS_ECOLI (P30844) (363 aa) fasta scores: E(): 0,49.7% id in 354 aa, and to Salmonella typhimurium sensor protein BasS or PmrB or ParB SW:BASS_SALTY (P36557) (356 aa) fasta scores: E(): 0, 50.4% id in 349 aa. (355 aa)
arcBSimilar to Escherichia coli aerobic respiration control sensor protein ArcB SW:ARCB_ECOLI (P22763) (776 aa) fasta scores: E(): 0, 75.9% id in 781 aa, and to Vibrio cholerae sensor histidine kinase FexB or VC2369 TR:Q9KPJ8 (EMBL:AE004307) (785 aa) fasta scores: E(): 0, 58.8% id in 779 aa. (778 aa)
yhdAPutative exported protein; Similar to Escherichia coli hypothetical 73.3 kDa protein in mreB-accB intergenic region YhdA SW:YHDA_ECOLI (P13518) (646 aa) fasta scores: E(): 0, 50.7% id in 641 aa,and to Vibrio cholerae MshA biogenesis protein Vc0398 TR:Q9KUW1 (EMBL:AE004128) (673 aa) fasta scores: E(): 0,36.1% id in 646 aa. (638 aa)
YPO3965Probable hybrid two-component system regulatory protein. CDS contains both sensor histidine kinase domain and response regulator receiver domain. C-terminus is similar to Rhizobium leguminosarum regulatory protein FixL TR:Q52824 (EMBL:Z70305) (641 aa) fasta scores: E(): 0,33.3% id in 519 aa, and to Pseudomonas syringae histidine protein kinase-response regulator hybrid protein CvgsY TR:Q9WWH9 (EMBL:AF133262) (671 aa) fasta scores: E(): 0,44.6% id in 383 aa. (851 aa)
yhjKPutative membrane protein; Similar to Escherichia coli protein YhjK SW:YHJK_ECOLI (P37649) (651 aa) fasta scores: E(): 0, 47.9% id in 653 aa. C-terminus is similar to the C-terminal region of Pseudomonas aeruginosa hypothetical protein PA4367 TR:AAG07755 (EMBL:AE004852) (687 aa) fasta scores: E(): 0, 29.6% id in 686 aa. (671 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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