STRINGSTRING
YPO0166 YPO0166 YPO0402 YPO0402 YPO0403 YPO0403 YPO0404 YPO0404 YPO0405 YPO0405 ptsP ptsP YPO0851 YPO0851 bglA bglA fpr-2 fpr-2 fpk fpk fruA fruA glcA glcA ycfO ycfO nagK nagK mtfA mtfA gptB gptB manY manY gptB-2 gptB-2 YPO2036 YPO2036 manA manA mlc mlc anmK anmK YPO2446 YPO2446 YPO2562 YPO2562 YPO2569 YPO2569 nagD nagD nagC nagC nagA nagA glmD glmD nagE nagE celA celA celB celB celC celC celD celD chbG chbG YPO2782 YPO2782 murQ murQ hpr hpr ptsI ptsI crr crr ampG ampG mrsA mrsA ptsN ptsN rapZ rapZ npr npr mtlD mtlD mtlA mtlA glmS glmS glmU glmU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YPO0166Putative glycosyl hydrolase; Similar to Escherichia coli 6-phospho-beta-glucosidase CelF SW:CELF_ECOLI (P17411) (449 aa) fasta scores: E(): 0, 43.2% id in 440 aa and to Vibrio cholerae 6-phospho-beta-glucosidase VC1284 TR:Q9KSH2 (EMBL:AE004207) (440 aa) fasta scores: E(): 0, 55.9% id in 433 aa. (437 aa)
YPO0402PTS system, IIB component; Similar to many carbohydrate phosphotransferase system IIB components e.g. Escherichia coli PTS system,fructose-like-2 IIB component 2 FrwD SW:PTWX_ECOLI (P32676) (113 aa) fasta scores: E(): 3.2e-23, 52.7% id in 110 aa. (114 aa)
YPO0403PTS system, IIB component; Similar to many carbohydrate phosphotransferase IIB components e.g. Escherichia coli PTS system,fructose-like-2 IIB component 1 FrwB, SW:PTWB_ECOLI (P32673) (106 aa) fasta scores: E(): 0, 82.7% id in 104 aa. Similar to part of Rhodobacter capsulatus PTS system,fructose-specific IIBC component FruA SW:PTFB_RHOCA (P23387) (578 aa) fasta scores: E(): 6.3e-16, 47.4% id in 97 aa and to Escherichia coli PTS system, fructose-specific IIBC component FruA, PtsF, SW:PTFB_ECOLI (P20966) (563 aa) fasta scores: E(): 1e-15, 49.5% id in 97 aa. (106 aa)
YPO0404PTS system, IIC component; Similar to many carbohydrate phosphotransferase IIC components e.g. part of Escherichia coli PTS system,fructose-specific IIBC component FruA SW:PTFB_ECOLI (P20966) (563 aa) fasta scores: E(): 0, 40.7% id in 329 aa and to Escherichia coli PTS system, fructose-like-2 IIC component FrwC SW:PTWC_ECOLI (P32672) (359 aa) fasta scores: E(): 0, 76.5% id in 358 aa. (361 aa)
YPO0405Similar to e.g. Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsI,SW:PT1_ECOLI (P08839) (575 aa) fasta scores: E(): 0, 36.0% id in 583 aa, but has both N- and C-terminal extensions. Also similar to Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsA,SW:PT1A_ECOLI (P32670) (711 aa) fasta scores: E(): 0, 64.5% id in 726 aa and to Escherichia coli putative phosphoenolpyruvate-protein phosphotransferase YpdD,SW:YPDD_ECOLI (P77439) (831 aa) fasta scores: E(): 0, 41.5% id in 853 aa. (852 aa)
ptsPSimilar to Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsP SW:PT1P_ECOLI (P37177) (748 aa) fasta scores: E(): 0, 79.3% id in 747 aa, and to Vibrio cholerae phosphoenolpyruvate-protein phosphotransferase VC0672 TR:Q9KU52 (EMBL:AE004153) (748 aa) fasta scores: E(): 0,51.2% id in 752 aa. Escherichia coli protein also possesses a putative sensory transduction domain and is possible transcriptional regulator; Belongs to the PEP-utilizing enzyme family. (748 aa)
YPO0851PTS transport protein (partial); Probable gene remnant, similar to C-terminal regions of Escherichia coli phosphenolpyruvate-dependent sugar phosphotransferase system (PTS) glucose-specific IIBC component PtsG SW:PTGB_ECOLI (P05053) (477 aa) fasta scores: E(): 2.3e-11, 54.1% id in 74 aa, and to Salmonella typhimurium PTS system, glucose-specific IIBC component PtsG SW:PTGB_SALTY (P37439) (477 aa) fasta scores: E(): 4.3e-11, 52.7% id in 74 aa; was marked partial. (103 aa)
bglA6-phospho-beta-glucosidase; Similar to Escherichia coli 6-phospho-beta-glucosidase BglA SW:BGLA_ECOLI (Q46829) (479 aa) fasta scores: E(): 0, 78.6% id in 473 aa, and to Bacillus subtilis 6-phospho-beta-glucosidase BglA SW:BGLA_BACSU (P42973) (479 aa) fasta scores: E(): 0, 63.9% id in 476 aa; Belongs to the glycosyl hydrolase 1 family. (478 aa)
fpr-2Fpr protein; Similar to Salmonella typhimurium PTS system,fructose-specific IIa/FPr component FruB SW:PTFA_SALTY (P17127) (376 aa) fasta scores: E(): 0, 71.0% id in 376 aa,and to Escherichia coli PTS system, fructose-specific IIa/FPr component FruB SW:PTFA_ECOLI (P24217) (376 aa) fasta scores: E(): 0, 69.4% id in 376 aa. (377 aa)
fpk1-phosphofructokinase; Similar to Escherichia coli 1-phosphofructokinase FruK or Fpk SW:K1PF_ECOLI (P23539) (312 aa) fasta scores: E(): 0, 92.0% id in 312 aa, and to Haemophilus influenzae 1-phosphofructokinase FruK SW:K1PF_HAEIN (P44330) (313 aa) fasta scores: E(): 0, 55.4% id in 305 aa; Belongs to the carbohydrate kinase PfkB family. (312 aa)
fruASimilar to Escherichia coli PTS system,fructose-specific IIBC component FruA or PtsF SW:PTFB_ECOLI (P20966) (563 aa) fasta scores: E(): 0, 77.2% id in 569 aa,and to Vibrio cholerae PTS system, fructose-specific IIBC component VCA0516 TR:Q9KM72 (EMBL:AE004382) (580 aa) fasta scores: E(): 0, 65.7% id in 531 aa. (566 aa)
glcASimilar to Escherichia coli PTS system,glucose-specific IIBC component Ptsg or Glca or UmG SW:PTGB_ECOLI (P05053) (477 aa) fasta scores: E(): 0, 90.4% id in 477 aa, and to Salmonella typhimurium PTS system,glucose-specific IIBC component PtsG SW:PTGB_SALTY (P37439) (477 aa) fasta scores: E(): 0, 88.7% id in 477 aa. (477 aa)
ycfOBeta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (343 aa)
nagKConserved hypothetical protein; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Belongs to the ROK (NagC/XylR) family. NagK subfamily. (256 aa)
mtfAConserved hypothetical protein; Involved in the regulation of ptsG expression by binding and inactivating Mlc. (270 aa)
gptBSimilar to Escherichia coli PTS system,mannose-specific IID component ManZ or PtsM or GptB SW:PTND_ECOLI (P08188) (286 aa) fasta scores: E(): 0, 86.6% id in 291 aa, and to Bacillus subtilis PTS system,fructose-specific IID component LevG SW:PTFD_BACSU (P26382) (275 aa) fasta scores: E(): 0, 60.4% id in 273 aa. This CDS has a small insertion at the N-terminal end relative to that of E.coli. (295 aa)
manYSimilar to Escherichia coli PTS system,mannose-specific IIC component ManY or PtsP or Pel SW:PTNC_ECOLI (P08187) (266 aa) fasta scores: E(): 0, 87.7% id in 269 aa, and to Klebsiella pneumoniae PTS system,sorbose-specific IIC component SorA SW:PTRC_KLEPN (P37082) (266 aa) fasta scores: E(): 0, 61.3% id in 266 aa. (265 aa)
gptB-2Similar to Escherichia coli PTS system,mannose-specific IIAB component ManX or PtsL or GptB SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0, 81.4% id in 323 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component iiab manL TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 0, 42.5% id in 332 aa. (324 aa)
YPO2036Putative transcriptional regulatory protein; N-terminal region is similar to the N-terminus of Bacillus subtilis xylose repressor XylR SW:XYLR_BACSU (P16557) (384 aa) fasta scores: E(): 2.4e-15, 27.7% id in 256 aa. Full length CDS has weak similarity to Rhizobium sp hypothetical protein Y4FQ SW:Y4FQ_RHISN (P55455) (392 aa) fasta scores: E(): 1.4e-27, 30.1% id in 366 aa. (370 aa)
manASimilar to Escherichia coli mannose-6-phosphate isomerase ManA SW:MANA_ECOLI (P00946) (391 aa) fasta scores: E(): 0, 71.0% id in 389 aa, and to Salmonella typhimurium mannose-6-phosphate isomerase ManA SW:MANA_SALTY (P25081) (391 aa) fasta scores: E(): 0, 70.2% id in 389 aa. (391 aa)
mlcLysR-family transcriptional regulatory protein (pseudogene); Pfam match to entry PF00126 HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 49.10, E-value 2.4e-11. (405 aa)
anmKConserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa)
YPO2446Similar to Escherichia coli hypothetical protein YniC SW:YNIC_ECOLI (P77247) (222 aa) fasta scores: E(): 0,65.9% id in 220 aa. (221 aa)
YPO2562Putative haloacid dehalogenase-like hydrolase; Similar to Saccharomyces cerevisiae DL-glycerol-3-phosphatase GPP2 SW:GPP2_YEAST (P40106) (250 aa) fasta scores: E(): 4.7e-15, 33.0% id in 212 aa, and to Escherichia coli hypothetical protein YfbT SW:YFBT_ECOLI (P77625) (222 aa) fasta scores: E(): 0, 72.4% id in 214 aa. (220 aa)
YPO2569Phosphotransferase enzyme II, A component; Similar to Escherichia coli phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), mannitol permease IIa protein, CmtB SW:PTYA_ECOLI (P32058) (147 aa) fasta scores: E(): 9.8e-18,42.3% id in 137 aa, and to Vibrio cholerae PTS system, IIa component VCA0245 TR:Q9KMS5 (EMBL:AE004364) (168 aa) fasta scores: E(): 1.5e-16, 37.4% id in 147 aa. (147 aa)
nagDSimilar to Escherichia coli N-acetylglucosamine utilization operon hypothetical protein NagD SW:NAGD_ECOLI (P15302) (250 aa) fasta scores: E(): 0, 86.0% id in 250 aa,and to Streptomyces coelicolor conserved hypothetical protein SCE20.17c TR:Q9RDA8 (EMBL:AL136058) (259 aa) fasta scores: E(): 0, 45.0% id in 249 aa. (250 aa)
nagCPutative N-acetylglucosamine regulatory protein; Similar to Escherichia coli N-acetylglucosamine repressor NagC or NagR or B0676 SW:NAGC_ECOLI (P15301) (406 aa) fasta scores: E(): 0, 78.0% id in 405 aa, and to Vibrio cholerae probable N-acetylglucosamine regulatory protein VC0993 TR:Q9KTB0 (EMBL:AE004181) (404 aa) fasta scores: E(): 0, 63.3% id in 403 aa. (409 aa)
nagASimilar to Escherichia coli N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_ECOLI (P15300) (382 aa) fasta scores: E(): 0, 75.1% id in 381 aa, and to Vibrio cholerae N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_VIBCH (O32445) (378 aa) fasta scores: E(): 0, 64.1% id in 376 aa. (381 aa)
glmDPutative glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa)
nagESimilar to Escherichia coli PTS system,N-acetylglucosamine-specific IIABC component NagE SW:PTAA_ECOLI (P09323) (648 aa) fasta scores: E(): 0, 52.6% id in 683 aa, and to Vibrio furnissii PTS permease for N-acetylglucosamine and glucose NagE TR:P96161 (EMBL:U65014) (496 aa) fasta scores: E(): 0, 69.9% id in 495 aa. (677 aa)
celASimilar to Escherichia coli PTS system,cellobiose-specific IIB component CelA SW:PTCB_ECOLI (P17409) (106 aa) fasta scores: E(): 2.6e-32, 82.5% id in 103 aa, and to Aeromonas hydrophila PTS system,cellobiose-specific IIB component CelA SW:PTCB_AERHY (P55901) (88 aa) fasta scores: E(): 1.4e-26, 80.7% id in 88 aa. (105 aa)
celBPTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (453 aa)
celCSimilar to Escherichia coli PTS system,cellobiose-specific IIA component CelC SW:PTCA_ECOLI (P17335) (116 aa) fasta scores: E(): 2.8e-29, 72.2% id in 115 aa, and to Vibrio cholerae PTS system,cellobiose-specific IIA component VC1283 TR:Q9KSH3 (EMBL:AE004207) (111 aa) fasta scores: E(): 4.6e-19, 57.7% id in 97 aa. (115 aa)
celDSimilar to Escherichia coli cel operon repressor CelD SW:CELD_ECOLI (P17410) (280 aa) fasta scores: E(): 0,67.9% id in 271 aa, and to Bacillus subtilis probable transcriptional regulator YbfI TR:O31449 (EMBL:Z99105) (275 aa) fasta scores: E(): 4.3e-06, 27.1% id in 251 aa. (280 aa)
chbGConserved hypothetical protein; Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobi [...] (253 aa)
YPO2782Putative membrane protein; Similar to Bacillus halodurans hypothetical protein BH0223 TR:Q9KG89 (EMBL:AP001507) (432 aa) fasta scores: E(): 0, 39.3% id in 422 aa, and to N-terminal region of Streptomyces coelicolor putative integral membrane protein SCJ21.17C TR:Q9S1Z0 (EMBL:AL109747) (516 aa) fasta scores: E(): 0, 48.2% id in 434 aa. (418 aa)
murQPutative glucokinase protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (295 aa)
hprProbable phosphocarrier protein component of a phosphoenolpyruvate-dependent phosphotransferase system (PTS). Similar to Escherichia coli and Salmonella typhimurium phosphocarrier protein PtsH SW:PTHP_ECOLI (P07006) (85 aa) fasta scores: E(): 4.9e-30, 97.6% id in 85 aa, and to Klebsiella pneumoniae phosphocarrier protein PtsH SW:PTHP_KLEPN (P16481) (85 aa) fasta scores: E(): 8e-30, 96.5% id in 85 aa. (85 aa)
ptsIPTS sytem, enzyme I component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa)
crrProbable glucose-specific IIA component of a phosphoenolpyruvate-dependent phosphotransferase system (PTS). Similar to Salmonella typhimurium PTS system,glucose-specific IIA component Crr SW:PTGA_SALTY (P02908) (168 aa) fasta scores: E(): 0, 94.0% id in 168 aa, and to Escherichia coli PTS system, glucose-specific IIA component Crr SW:PTGA_ECOLI (P08837) (168 aa) fasta scores: E(): 0,92.9% id in 168 aa. (169 aa)
ampGBeta-lactamase induction signal transducer AmpG; Similar to Escherichia coli AmpG protein SW:AMPG_ECOLI (P36670) (491 aa) fasta scores: E(): 0, 73.1% id in 491 aa, and to Neisseria meningitidis putative integral membrane signal transducer protein Nma2127 TR:Q9JSU7 (EMBL:AL162758) (427 aa) fasta scores: E(): 0,40.6% id in 399 aa. (492 aa)
mrsAProbable phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (446 aa)
ptsNProbable sigma (54) modulation protein (pseudogene); Pfam match to entry PF02482 Ribosomal_S30, score 45.80, E-value 9.7e-10. (160 aa)
rapZConserved hypothetical protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. (284 aa)
nprSimilar to Escherichia coli phosphocarrier protein Npr SW:PTSO_ECOLI (P33996) (90 aa) fasta scores: E(): 1.2e-29, 87.8% id in 90 aa, and to Klebsiella pneumoniae phosphocarrier protein Npr SW:PTSO_KLEPN (P51185) (90 aa) fasta scores: E(): 1.1e-28, 82.2% id in 90 aa. (90 aa)
mtlDSimilar to Klebsiella pneumoniae mannitol-1-phosphate 5-dehydrogenase MtlD SW:MTLD_KLEPN (Q9XBM6) (382 aa) fasta scores: E(): 0, 76.6% id in 380 aa,and to Escherichia coli mannitol-1-phosphate 5-dehydrogenase MtlD SW:MTLD_ECOLI (P09424) (382 aa) fasta scores: E(): 0, 75.7% id in 382 aa. (387 aa)
mtlASimilar to Escherichia coli PTS system,mannitol-specific IIABC component MtlA SW:PTMA_ECOLI (P00550) (637 aa) fasta scores: E(): 0, 81.7% id in 638 aa,and to Klebsiella pneumoniae PTS system, mannitol-specific IIABC component MtlA SW:PTMA_KLEPN (Q9XBM7) (635 aa) fasta scores: E(): 0, 81.1% id in 635 aa. (643 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
Server load: medium (66%) [HD]