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YPO0034 YPO0034 pyrE pyrE YPO0141 YPO0141 codA codA adeK adeK b4384 b4384 b0032 b0032 b0033 b0033 YPO0913 YPO0913 YPO1033 YPO1033 pndA pndA pyrD pyrD cdd cdd b2066 b2066 b1062 b1062 tmk tmk purB purB purT purT tdk tdk pyrF pyrF YPO2559 YPO2559 cvpA cvpA purF purF ads ads upp upp purI purI purN purN guaA guaA guaB guaB purI-2 purI-2 purC purC purE purE purK purK gsk gsk apt apt ppnP ppnP gpp gpp b0125 b0125 guaC guaC cpdB cpdB pyrB pyrB pyrI pyrI purH purH purD purD udp udp yieG yieG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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YPO0034Similar to Escherichia coli putative purine permease YicE SW:YICE_ECOLI (P27432) (463 aa) fasta scores: E(): 0,84.0% id in 462 aa and to Vibrio cholerae xanthine/uracil permease family protein vc2712 TR:Q9KNM0 (EMBL:AE004337) (480 aa) fasta scores: E(): 0, 69.1% id in 450 aa. (461 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa)
YPO0141Similar to Escherichia coli hypothetical protein YrfG SW:YRFG_ECOLI (P45801) (222 aa) fasta scores: E(): 0,67.0% id in 221 aa. (226 aa)
codASimilar to Escherichia coli cytosine deaminase CodA SW:CODA_ECOLI (P25524) (426 aa) fasta scores: E(): 0, 80.5% id in 425 aa. (436 aa)
adeKAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
b4384Similar to Escherichia coli purine nucleoside phosphorylase DeoD SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 91.1% id in 236 aa, and to Klebsiella pneumoniae purine nucleoside phosphorylase DeoD SW:DEOD_KLEPN (Q59482) (239 aa) fasta scores: E(): 0, 88.7% id in 238 aa. (239 aa)
b0032Similar to Escherichia coli carbamoyl-phosphate synthase small chain CarA SW:CARA_ECOLI (P00907) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase small chain CarA SW:CARA_SALTY (P14845) (382 aa) fasta scores: E(): 0, 86.4% id in 381 aa; Belongs to the CarA family. (391 aa)
b0033Similar to Escherichia coli carbamoyl-phosphate synthase large chain CarB SW:CARB_ECOLI (P00968) (1072 aa) fasta scores: E(): 0, 92.6% id in 1072 aa, and to Salmonella typhimurium carbamoyl-phosphate synthase large chain CarB SW:CARB_SALTY (P14846) (1074 aa) fasta scores: E(): 0, 92.7% id in 1072 aa. (1077 aa)
YPO0913Putative 5-formyltetrahydrofolate cyclo-ligase-family protein; Similar to Escherichia coli hypothetical protein YgfA SW:YGFA_ECOLI (P09160) (182 aa) fasta scores: E(): 0,69.6% id in 181 aa, and to Oryctolagus cuniculus 5-formyltetrahydrofolate cyclo-ligase SW:FTHC_RABIT (P80405) (201 aa) fasta scores: E(): 2.4e-13, 32.1% id in 187 aa. (198 aa)
YPO1033Similar to Escherichia coli hypothetical protein YgdH SW:YGDH_ECOLI (P37350) (454 aa) fasta scores: E(): 0,82.6% id in 454 aa, and to Vibrio cholerae hypothetical protein VC0899 TR:Q9KTK3 (EMBL:AE004173) (457 aa) fasta scores: E(): 0, 69.9% id in 455 aa. (454 aa)
pndAXanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (287 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
b2066Uridine kinase; Similar to Escherichia coli uridine kinase SW:URK_ECOLI (P31218) (213 aa) fasta scores: E(): 0, 91.1% id in 213 aa, and to Vibrio cholerae uridine kinase vc1038 TR:Q9KT67 (EMBL:AE004185) (219 aa) fasta scores: E(): 0,75.0% id in 208 aa. (213 aa)
b1062Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. 5-bromo-2'deoxyuridine monophosphate is also a good phosphate acceptor; Belongs to the thymidylate kinase family. (212 aa)
purBSimilar to Escherichia coli adenylosuccinate lyase PurB SW:PUR8_ECOLI (P25739) (456 aa) fasta scores: E(): 0,88.6% id in 456 aa, and to Vibrio cholerae adenylosuccinate lyase Vc1126 TR:Q9KSY0 (EMBL:AE004193) (456 aa) fasta scores: E(): 0, 78.5% id in 456 aa. (456 aa)
purTPhosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
tdkThymidine kinase; Similar to Escherichia coli thymidine kinase Tdk SW:KITH_ECOLI (P23331) (205 aa) fasta scores: E(): 0, 76.4% id in 191 aa, and to Vibrio cholerae thymidine kinase VC1167 TR:Q9KST9 (EMBL:AE004197) (192 aa) fasta scores: E(): 0, 72.6% id in 190 aa. (196 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa)
YPO2559Conserved hypothetical protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (197 aa)
cvpASimilar to Escherichia coli colicin V production protein CvpA SW:CVPA_ECOLI (P08550) (162 aa) fasta scores: E(): 0, 83.1% id in 160 aa, and to Haemophilus influenzae possible colicin V production protein CvpA SW:CVPA_HAEIN (P45108) (163 aa) fasta scores: E(): 0, 67.5% id in 160 aa. (169 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
adsPutative FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
purIPutative phosphoribosylaminoimidazole synthetase; Similar to Salmonella typhimurium probable 5'-phosphoribosyl-5-aminoimidazole synthetase PurI TR:P74883 (EMBL:U68765) (345 aa) fasta scores: E(): 0,83.5% id in 345 aa, and to Escherichia coli probable phosphoribosylaminoimidazole synthetase PurM TR:AAG14577 (EMBL:AF293164) (350 aa) fasta scores: E(): 0, 82.6% id in 345 aa. (347 aa)
purNPutative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
guaAPutative GMP synthase; Catalyzes the synthesis of GMP from XMP. (525 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
purI-2Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1296 aa)
purCSimilar to Escherichia coli phosphoribosylaminoimidazole-succinocarboxamide synthase PurC SW:PUR7_ECOLI (P21155) (237 aa) fasta scores: E(): 0,86.9% id in 237 aa, and to Pseudomonas aeruginosa phosphoribosylaminoimidazole-succinocarboxamide synthase Purc or Pa1013 TR:AAG04402 (EMBL:AE004533) (236 aa) fasta scores: E(): 0, 72.5% id in 236 aa; Belongs to the SAICAR synthetase family. (237 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit PurK; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (354 aa)
gskSimilar to Escherichia coli inosine-guanosine kinase Gsk SW:INGK_ECOLI (P22937) (434 aa) fasta scores: E(): 0,83.4% id in 434 aa, and to Yersinia enterocolitica inosine-guanosine kinase Gsk TR:Q56875 (EMBL:U46859) (434 aa) fasta scores: E(): 0, 90.3% id in 434 aa. (434 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (187 aa)
ppnPConserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (95 aa)
gppXanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
b0125Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa)
cpdBSimilar to Escherichia coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor CpdB SW:CN16_ECOLI (P08331) (647 aa) fasta scores: E(): 0, 76.0% id in 646 aa, and to Yersinia enterocolitica 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor CpdB SW:CN16_YEREN (P53052) (652 aa) fasta scores: E(): 0, 91.3% id in 652 aa; Belongs to the 5'-nucleotidase family. (656 aa)
pyrBSimilar to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 84.8% id in 310 aa,and to Erwinia herbicola aspartate transcarbamylase catalytic subunit PyrB TR:Q9RMS8 (EMBL:AF190426) (311 aa) fasta scores: E(): 0, 85.9% id in 311 aa. (311 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 0, 87.1% id in 529 aa, and to Salmonella typhimurium bifunctional purine biosynthesis protein PurH SW:PUR9_SALTY (P26978) (508 aa) fasta scores: E(): 0, 86.8% id in 508 aa. (529 aa)
purDSimilar to Escherichia coli phosphoribosylamine--glycine ligase PurD SW:PUR2_ECOLI (P15640) (429 aa) fasta scores: E(): 0, 80.8% id in 426 aa,and to Salmonella typhimurium phosphoribosylamine--glycine ligase PurD or Stmf1.31 SW:PUR2_SALTY (P26977) (429 aa) fasta scores: E(): 0, 79.6% id in 426 aa. (428 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
yieGXanthine/uracil permeases family protein; Similar to Escherichia coli hypothetical protein YieG SW:YIEG_ECOLI (P31466) (445 aa) fasta scores: E(): 0,86.8% id in 432 aa, and to Escherichia coli hypothetical protein YicO or b3664 SW:YICO_ECOLI (P31440) (470 aa) fasta scores: E(): 0, 76.2% id in 445 aa. (442 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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