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crpA crpA rplF rplF rpsE rpsE rpsM rpsM rpsK rpsK crpB crpB dnaA dnaA nitA nitA relC relC rplA rplA rplL rplL rplM rplM rpsI rpsI rpmA rpmA barA barA pyrG pyrG luxS luxS rplS rplS phoB phoB nmpB nmpB adk adk aroC aroC mclA mclA fit fit pdzA pdzA supX supX gapA gapA fadD fadD uvrY uvrY cspC-2 cspC-2 cheB cheB cheA cheA mgtB mgtB mgtC mgtC cspC cspC phoP phoP phoQ phoQ ompF ompF ompC ompC gyrA gyrA grpE grpE b2620 b2620 b0172 b0172 tsf tsf rpsB rpsB recC recC pgk pgk dnaJ dnaJ dnaK dnaK hemN hemN kmt kmt envZ envZ rpsl rpsl nusE nusE rplC rplC eryA eryA rplB rplB rpsS rpsS rpsC rpsC rplP rplP rplN rplN rplE rplE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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crpA60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsE30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (167 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (118 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
crpB10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
dnaAChromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (462 aa)
nitATranscription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
relC50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (234 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpsISimilar to Escherichia coli 30S ribosomal protein S9 RpsI SW:RS9_ECOLI (P02363) (129 aa) fasta scores: E(): 0,92.2% id in 129 aa, and to Vibrio cholerae ribosomal protein S9 Vc0571 TR:Q9KUF0 (EMBL:AE004142) (130 aa) fasta scores: E(): 0, 86.9% id in 130 aa; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rpmASimilar to Escherichia coli 50S ribosomal protein L27 RpmA SW:RL27_ECOLI (P02427) (84 aa) fasta scores: E(): 5e-31, 94.0% id in 84 aa, and to Vibrio cholerae ribosomal protein L27 Vc0436 TR:Q9KUS9 (EMBL:AE004131) (86 aa) fasta scores: E(): 1.2e-29, 91.6% id in 83 aa; Belongs to the bacterial ribosomal protein bL27 family. (85 aa)
barATwo-component regulatory protein; Similar to Escherichia coli sensor protein BarA SW:BARA_ECOLI (P26607) (918 aa) fasta scores: E(): 0, 61.6% id in 928 aa, and to Erwinia carotovora subsp. carotovora sensor/regulator protein RpfA TR:O08235 (EMBL:U62023) (929 aa) fasta scores: E(): 0, 59.7% id in 938 aa. (930 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
luxSAutoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa)
phoBSimilar to Escherichia coli phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_ECOLI (P08402) (229 aa) fasta scores: E(): 0, 90.0% id in 229 aa,and to Shigella dysenteriae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_SHIDY (P45606) (229 aa) fasta scores: E(): 0, 89.5% id in 229 aa. (229 aa)
nmpBSimilar to Escherichia coli phosphate regulon sensor protein PhoR or NmpB SW:PHOR_ECOLI (P08400) (431 aa) fasta scores: E(): 0, 73.2% id in 426 aa, and to Shigella dysenteriae phosphate regulon sensor protein PhoR SW:PHOR_SHIDY (P45609) (431 aa) fasta scores: E(): 0, 72.5% id in 426 aa. (438 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
mclASigma E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] (218 aa)
fitTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (183 aa)
pdzA50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
supXDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (871 aa)
gapASimilar to Escherichia coli glyceraldehyde 3-phosphate dehydrogenase A GapA SW:G3P1_ECOLI (P06977) (330 aa) fasta scores: E(): 0, 90.9% id in 330 aa, and to Trypanosoma brucei brucei cytosolic glyceraldehyde 3-phosphate dehydrogenase SW:G3PC_TRYBB (P10097) (330 aa) fasta scores: E(): 0, 84.8% id in 329 aa; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
fadDlong-chain-fatty-acid-CoA ligase; Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids; Belongs to the ATP-dependent AMP-binding enzyme family. (562 aa)
uvrYResponse regulator protein; Similar to Escherichia coli UvrY protein SW:UVRY_ECOLI (P07027) (218 aa) fasta scores: E(): 0, 82.9% id in 217 aa, and to Salmonella typhimurium SirA TR:P96058 (EMBL:U67869) (218 aa) fasta scores: E(): 0, 83.9% id in 217 aa. (218 aa)
cspC-2Cold shock protein; Similar to Escherichia coli cold shock-like protein CspC or MsmB SW:CSPC_ECOLI (P36996) (68 aa) fasta scores: E(): 4.1e-27, 98.5% id in 68 aa, and to Salmonella typhimurium cold shock-like protein CspC SW:CSPC_SALTY (O68636) (68 aa) fasta scores: E(): 1.9e-26, 97.1% id in 68 aa. Paralogues include YPO1655, YPO2595, YPO2659, YPO3644,YPO3643, YPO1366, and YPO1398. (69 aa)
cheBProtein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
cheAChemotaxis protein CheA; Similar to Escherichia coli chemotaxis regulatory protein CheA SW:CHEA_ECOLI (P07363) (654 aa) fasta scores: E(): 0, 69.8% id in 716 aa, and to Salmonella typhimurium chemotaxis protein CheA SW:CHEA_SALTY (P09384) (671 aa) fasta scores: E(): 0, 72.2% id in 716 aa. This CDS contains internal insertions relative to that of E.coli and S. typhimurium. (723 aa)
mgtBSimilar to Salmonella typhimurium Mg2+ transport ATPase protein B, MgtB important for macrophage survival TR:Q9S682 (EMBL:AF106566) (908 aa) fasta scores: E(): 0,72.4% id in 901 aa, and to Pseudomonas aeruginosa Mg2+ transport ATPase TR:AAG08210 (Q9HUY5) (903 aa) fasta scores: E(): 0, 74.8% id in 894 aa. (899 aa)
mgtCSimilar to Salmonella typhimurium Mg(2+) transport ATPase protein C MgtC, important for macrophage survival SW:ATMC_SALTY (P22037) (231 aa) fasta scores: E(): 0, 63.1% id in 233 aa, and to Pseudomonas aeruginosa conserved hypothetical protein TR:AAG08023 (Q9HVF9) (234 aa) fasta scores: E(): 0, 54.1% id in 229 aa. (236 aa)
cspCCold shock protein; Similar to Escherichia coli cold shock-like protein CspC or MsmB SW:CSPC_ECOLI (P36996) (68 aa) fasta scores: E(): 4.9e-23, 84.8% id in 66 aa, and to Yersinia enterocolitica major cold shock protein Cspa2 TR:Q9RIF1 (EMBL:U82821) (70 aa) fasta scores: E(): 4.2e-22, 80.0% id in 70 aa. (70 aa)
phoPResponse regulator protein; Similar to the previously sequenced Yersinia pestis PhoP protein TR:P74992 (EMBL:Y08758) (223 aa) fasta scores: E(): 0, 100.0% id in 223 aa, to Yersinia pseudotuberculosis PhoP protein TR:P74991 (EMBL:X66587) (223 aa) fasta scores: E(): 0, 99.1% id in 223 aa, to Yersinia enterocolitica PhoP protein TR:O87919 (EMBL:AJ011832) (200 aa) fasta scores: E(): 0, 98.5% id in 200 aa, and to Escherichia coli transcriptional regulatory protein PhoP SW:PHOP_ECOLI (P23836) (223 aa) fasta scores: E(): 0, 81.1% id in 222 aa. (223 aa)
phoQSensor protein kinase; Similar to Escherichia coli membrane bound two component sensor protein PhoQ SW:PHOQ_ECOLI (P23837) (486 aa) fasta scores: E(): 0, 62.1% id in 478 aa, and to Salmonella typhimurium PhoQ protein TR:Q9L3L1 (EMBL:AJ272210) (487 aa) fasta scores: E(): 0, 62.4% id in 473 aa. (484 aa)
ompFSimilar to Klebsiella pneumoniae outer membrane protein C OmpC SW:OMPC_KLEPN (Q48473) (363 aa) fasta scores: E(): 0, 62.2% id in 370 aa, to Escherichia coli outer membrane pore protein E OmpE SW:PHOE_ECOLI (P02932) (351 aa) fasta scores: E(): 0, 58.3% id in 362 aa and to Yersinia pestis YPO1205 (371 aa) fasta scores: E(): 0,62.2% identity in 376 aa overlap; Belongs to the Gram-negative porin family. (360 aa)
ompCSimilar to Escherichia coli outer membrane protein C precursor OmpC or MeoA or Par SW:OMPC_ECOLI (P06996) (367 aa) fasta scores: E(): 0, 70.3% id in 381 aa, and to Serratia marcescens outer membrane protein C precursor OmpC SW:OMPC_SERMA (Q54471) (376 aa) fasta scores: E(): 0, 68.1% id in 382 aa; Belongs to the Gram-negative porin family. (371 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (891 aa)
grpEHeat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] (192 aa)
b2620SsrA-binding protein (small protein B); Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosom [...] (160 aa)
b0172Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
tsfElongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (285 aa)
rpsBSimilar to Escherichia coli 30S ribosomal protein S2 RpsB SW:RS2_ECOLI (P02351) (240 aa) fasta scores: E(): 0,93.8% id in 240 aa; Belongs to the universal ribosomal protein uS2 family. (241 aa)
recCExodeoxyribonuclease V gamma chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (1123 aa)
pgkSimilar to Escherichia coli phosphoglycerate kinase Pgk SW:PGK_ECOLI (P11665) (386 aa) fasta scores: E(): 0,88.6% id in 386 aa, and to Haemophilus influenzae phosphoglycerate kinase Pgk SW:PGK_HAEIN (P43726) (385 aa) fasta scores: E(): 0, 79.2% id in 385 aa. (387 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (379 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (636 aa)
hemNHighly similar to Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN SW:HEMN_ECOLI (P32131) (457 aa) fasta scores: E(): 0, 78.6% id in 457 aa; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
kmtSimilar to Escherichia coli transcriptional regulatory protein OmpR SW:OMPR_ECOLI (P03025) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa and to Yersinia enterocolitica OmpR TR:P74982 (EMBL:Y08950) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa. (239 aa)
envZSimilar to Escherichia coli osmolarity sensor protein EnvZ SW:ENVZ_ECOLI (P02933) (450 aa) fasta scores: E(): 0, 86.6% id in 440 aa, and to Yersinia enterocolitica EnvZ TR:O06468 (EMBL:Y08950) (450 aa) fasta scores: E(): 0,93.8% id in 450 aa. (450 aa)
rpsl30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (124 aa)
nusE30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (209 aa)
eryA50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (201 aa)
rplB50S ribosomal protein l2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (232 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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