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lsrA lsrA lsrG lsrG lsrF lsrF lsrB lsrB lsrK lsrK uxaB uxaB xylB-2 xylB-2 deoR deoR lacZ lacZ luxS luxS xylB xylB
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
lsrAPutative ABC transporter ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (By similarity). (527 aa)
lsrGConserved hypothetical protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family. (96 aa)
lsrFPutative aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (291 aa)
lsrBPutative periplasmic solute-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity). (339 aa)
lsrKPutative transcriptional regulator (pseudogene); Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. (530 aa)
uxaBSimilar to Escherichia coli altronate oxidoreductase UxaB SW:UXAB_ECOLI (P24214) (483 aa) fasta scores: E(): 0,72.3% id in 481 aa, and to Bacillus subtilis hypothetical altronate oxidoreductase YjmI TR:O34354 (EMBL:AF015825) (480 aa) fasta scores: E(): 0, 45.1% id in 483 aa; Belongs to the mannitol dehydrogenase family. UxaB subfamily. (483 aa)
xylB-2Putative carbohydrate kinase; Similar to Thermoanaerobacter ethanolicus xylulose kinase XylB TR:O30364 (EMBL:AF001974) (500 aa) fasta scores: E(): 0, 40.7% id in 511 aa, and to Bacillus subtilis xylulose kinase XylB SW:XYLB_BACSU (P39211) (499 aa) fasta scores: E(): 0, 36.6% id in 517 aa. (517 aa)
deoRSimilar to Escherichia coli deoxyribose operon repressor DeoR SW:DEOR_ECOLI (P06217) (252 aa) fasta scores: E(): 0, 56.7% id in 252 aa, and to Salmonella typhimurium transcriptional activator DeoR TR:O30907 (EMBL:AF020809) (252 aa) fasta scores: E(): 0, 57.1% id in 252 aa. (254 aa)
lacZBeta-galactosidase; Similar to Escherichia coli beta-galactosidase LacZ SW:BGAL_ECOLI (P00722) (1023 aa) fasta scores: E(): 0,62.5% id in 1046 aa, and to Enterobacter cloacae beta-galactosidase lacZ SW:BGAL_ENTCL (Q47077) (1028 aa) fasta scores: E(): 0, 60.4% id in 1046 aa; Belongs to the glycosyl hydrolase 2 family. (1060 aa)
luxSAutoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
xylBXylulose kinase; Similar to Escherichia coli xylulose kinase XylB SW:XYLB_ECOLI (P09099) (484 aa) fasta scores: E(): 0, 72.0% id in 482 aa, and to Klebsiella pneumoniae xylulose kinase XylB SW:XYLB_KLEPN (P29444) (483 aa) fasta scores: E(): 0,66.4% id in 482 aa. (484 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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