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pykF pykF kmt kmt cap cap tufA tufA b4154 b4154 hflX hflX talB talB clpB clpB dinA dinA tkt tkt drpA drpA ams ams fyuA fyuA irp5 irp5 irp1 irp1 irp2 irp2 ybtA ybtA irp6 irp6 irp7 irp7 irp8 irp8 irp9 irp9 oppA oppA slyA slyA mtlK mtlK omp4 omp4 ureB ureB ureC ureC ureE ureE rpoE rpoE fadL fadL ybbN ybbN htpG htpG ahpC ahpC clpB-2 clpB-2 csrA csrA degP degP pcnB pcnB pnp pnp tufA-2 tufA-2 fam fam cmr cmr atpD atpD
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pykFPyruvate kinase I; Similar to Escherichia coli pyruvate kinase I PykF SW:KPY1_ECOLI (P14178) (470 aa) fasta scores: E(): 0, 86.6% id in 470 aa, and to Salmonella typhimurium pyruvate kinase I PykF SW:KPY1_SALTY (P77983) (470 aa) fasta scores: E(): 0, 86.6% id in 470 aa. (470 aa)
kmtSimilar to Escherichia coli transcriptional regulatory protein OmpR SW:OMPR_ECOLI (P03025) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa and to Yersinia enterocolitica OmpR TR:P74982 (EMBL:Y08950) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa. (239 aa)
capcAMP-regulatory protein; Similar to Escherichia coli and Shigella flexneri catabolite gene activator Crp SW:CRP_ECOLI (P03020) (210 aa) fasta scores: E(): 0, 98.6% id in 210 aa. (210 aa)
tufAElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
b4154Similar to Escherichia coli fumarate reductase flavoprotein subunit FrdA SW:FRDA_ECOLI (P00363) (601 aa) fasta scores: E(): 0, 85.3% id in 605 aa. (607 aa)
hflXGTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (428 aa)
talBTransaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa)
clpBPutative Clp ATPase; Similar to Escherichia coli ClpB protein, which is thought to form part of a multi-chaperone system supressing protein aggregation, SW:CLPB_ECOLI (P03815) (857 aa) fasta scores: E(): 0, 35.1% identity in 883 aa overlap. Also similar to Yersinia enterocolitica Clp protease-associated protein ClpB TR:AAG00524 (EMBL:AF285784) (890 aa) fasta scores: E(): 0, 44.2% id in 866 aa. Contains small internal deletions relative to orthologues; Belongs to the ClpA/ClpB family. (867 aa)
dinADNA polymerase II; Similar to Escherichia coli DNA damage-inducible DNA polymerase II PolB SW:DPO2_ECOLI (P21189) (782 aa) fasta scores: E(): 0, 72.4% id in 783 aa, and to Pseudomonas aeruginosa DNA polymerase II PolB TR:AAG05275 (EMBL:AE004614) (787 aa) fasta scores: E(): 0, 74.4% id in 785 aa. (789 aa)
tktTransketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
drpAprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (572 aa)
amsRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1221 aa)
fyuAPesticin/yersiniabactin receptor protein; Receptor for the bacteriocin pesticin and for the siderophore yersiniabactin. (673 aa)
irp5Previously sequenced: Yersinia pestis yersiniabactin siderophore biosynthetic protein YbtE TR:Q56950 (EMBL:U50364) (525 aa) fasta scores: E(): 0, 100.0% id in 525 aa. Similar to Yersinia enterocolitica Irp5 protein TR:O54514 (EMBL:Y12527) (525 aa) fasta scores: E(): 0,97.9% id in 525 aa. (525 aa)
irp1Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein Irp1 TR:Q9Z373 (EMBL:AL031866) (3163 aa) fasta scores: E(): 0, 100.0% id in 3163 aa. Similar to Yersinia enterocolitica HMWP1 protein Irp1 TR:O54511 (EMBL:Y12527) (3161 aa) fasta scores: E(): 0, 97.9% id in 3163 aa. (3163 aa)
irp2Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein Irp2 TR:Q9Z399 (EMBL:AL031866) (2041 aa) fasta scores: E(): 0, 100.0% id in 2035 aa. Similar to Yersinia enterocolitica high-molecular-weight protein 2 Irp2 SW:HMP2_YEREN (P48633) (2035 aa) fasta scores: E(): 0, 98.6% id in 2035 aa. The previously sequenced Yersinia pestis Irp2 ORF starts at a valine situated 6 aa upstream from the methionine. However,the methionine start, has a good ribosome-binding site. (2035 aa)
ybtATranscriptional regulator YbtA; Previously sequenced as Yersinia pestis yersiniabactin transcriptional regulator YbtA TR:Q56951 (EMBL:U50452) (319 aa) fasta scores: E(): 0, 100.0% id in 319 aa. Similar to Yersinia enterocolitica yersiniabactin transcriptional regulator YbtA TR:Q9X9I4 (EMBL:AJ132668) (319 aa) fasta scores: E(): 0, 99.1% id in 319 aa. (319 aa)
irp6Previously sequenced as Yersinia pestis lipoprotein inner membrane ABC-transporter YbtP TR:Q9R7V3 (EMBL:AL031866) (600 aa) fasta scores: E(): 0, 100.0% id in 600 aa. Similar to Yersinia enterocolitica lipoprotein inner membrane ABC-transporter Irp6 TR:Q9X9I5 (EMBL:AJ132668) (600 aa) fasta scores: E(): 0, 98.0% id in 600 aa. (600 aa)
irp7Previously sequenced as Yersinia pestis inner membrane ABC-transporter YbtQ TR:Q9Z375 (EMBL:AL031866) (600 aa) fasta scores: E(): 0, 100.0% id in 600 aa. Similar to Yersinia enterocolitica inner membrane ABC-transporter Irp7 TR:Q9X9I6 (EMBL:AJ132668) (600 aa) fasta scores: E(): 0, 98.8% id in 600 aa. (600 aa)
irp8Putative signal transducer; Previously sequenced as Yersinia pestis putative signal transducer YbtX TR:Q9ZC28 (EMBL:AL031866) (462 aa) fasta scores: E(): 0, 100.0% id in 426 aa. similar to Yersinia enterocolitica signal transducer Irp8 TR:Q9X9I7 (EMBL:AJ132668) (462 aa) fasta scores: E(): 0, 98.1% id in 426 aa. There is a discrepancy with the start codon. The previously sequenced Y.pestis and Y. enterocolitica ORFs start at a methionine 36 aa upstream of the predicted start for this CDS. The selection for the alternative downstream methionine start codon for this CDS was supported by Y [...] (426 aa)
irp9Previously sequenced as Yersinia pestis putative salicylate synthetase YbtS TR:Q9Z396 (EMBL:AL031866) (434 aa) fasta scores: E(): 0, 100.0% id in 434 aa. Similar to Yersinia enterocolitica salicylate synthetase Irp9 TR:Q9X9I8 (EMBL:AJ132668) (434 aa) fasta scores: E(): 0,99.3% id in 434 aa. (434 aa)
oppASimilar to Salmonella typhimurium periplasmic oligopeptide-binding protein precursor OppA SW:OPPA_SALTY (P06202) (542 aa) fasta scores: E(): 0, 78.5% id in 545 aa,and to Escherichia coli periplasmic oligopeptide-binding protein precursor OppA SW:OPPA_ECOLI (P23843) (543 aa) fasta scores: E(): 0, 76.7% id in 545 aa. (545 aa)
slyAMarR-family transcriptional regulatory protein; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family. (143 aa)
mtlKSimilar to Pseudomonas fluorescens probable mannitol transport ATP-binding protein MtlK TR:O30494 (EMBL:AF007800) (367 aa) fasta scores: E(): 0, 46.7% id in 360 aa, and to Escherichia coli maltose/maltodextrin transport ATP-binding protein MalK SW:MALK_ECOLI (P02914) (371 aa) fasta scores: E(): 0, 47.1% id in 365 aa; Belongs to the ABC transporter superfamily. (359 aa)
omp4Similar to Serratia marcescens outer membrane protein Omp4 TR:Q54470 (EMBL:Z37157) (172 aa) fasta scores: E(): 0, 74.1% id in 174 aa, and to Escherichia coli outer membrane protein OmpX SW:OMPX_ECOLI (P36546) (171 aa) fasta scores: E(): 0, 70.7% id in 174 aa. (174 aa)
ureBUrease beta subunit; Previously sequenced as Yersinia pestis urease beta subunit UreB SW:URE2_YERPS (P52314) (144 aa) fasta scores: E(): 0, 100.0% id in 144 aa. Identical to the Yersinia pseudotuberculosis urease gamma subunit UreB, and similar to Yersinia enterocolitica urease beta subunit UreB SW:URE2_YEREN (P31495) (163 aa) fasta scores: E(): 0, 90.7% id in 140 aa. (144 aa)
ureCUrease alpha subunit; Previously sequenced as Yersinia pestis urease alpha subunit UreC SW:URE1_YERPE (Q9ZFR9) (571 aa) fasta scores: E(): 0, 100.0% id in 571 aa. Similar to Yersinia pseudotuberculosis urease alpha subunit ureC SW:URE1_YERPS (P52313) (571 aa) fasta scores: E(): 0, 99.8% id in 571 aa,and to Yersinia enterocolitica urease alpha subunit UreC SW:URE1_YEREN (P31494) (571 aa) fasta scores: E(): 0, 97.2% id in 571 aa; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (572 aa)
ureEUrease accessory protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (231 aa)
rpoEProbable alternative sigma factor. Similar to Escherichia coli RNA polymerase sigma E factor RpoE SW:RPOE_ECOLI (P34086) (191 aa) fasta scores: E(): 0, 92.7% id in 191 aa, and to Salmonella typhimurium RNA polymerase sigma E factor RpoE SW:RPOE_SALTY (P37401) (191 aa) fasta scores: E(): 0, 93.2% id in 191 aa; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
fadLSimilar to Escherichia coli long-chain fatty acid transport protein precursor FadL SW:FADL_ECOLI (P10384) (448 aa) fasta scores: E(): 0, 63.7% id in 455 aa, and to Vibrio cholerae long-chain fatty acid transport protein VCA0862 TR:Q9KL84 (EMBL:AE004414) (412 aa) fasta scores: E(): 0, 43.9% id in 424 aa. (423 aa)
ybbNPutative thioredoxin; Similar to Escherichia coli hypothetical 33.1 kDa protein in ushA-tesA intergenic region YbbN SW:YBBN_ECOLI (P77395) (296 aa) fasta scores: E(): 0, 71.6% id in 289 aa,and to Vibrio cholerae hypothetical protein Vc0977 TR:Q9KTC5 (EMBL:AE004179) (306 aa) fasta scores: E(): 0,40.8% id in 292 aa. (289 aa)
htpGHeat shock protein HtpG; Molecular chaperone. Has ATPase activity. (624 aa)
ahpCSimilar to Campylobacter jejuni alkyl hydroperoxide reductase subunit C AhpC or Cj0334 TR:Q9ZI13 (EMBL:AF044271) (198 aa) fasta scores: E(): 0, 59.8% id in 199 aa, and to Vibrio cholerae antioxidant, AhpC/Tsa family Vc0731 TR:Q9KTZ9 (EMBL:AE004159) (207 aa) fasta scores: E(): 0, 71.5% id in 200 aa. (200 aa)
clpB-2Clp ATPase; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB family. (857 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
degPGlobal stress requirement protein GsrA; Similar to Yersinia enterocolitica GsrA protein TR:P74978 (EMBL:D78376) (478 aa) fasta scores: E(): 0,92.3% id in 481 aa, and to Escherichia coli protease Do precursor DegP or HtrA or Ptd SW:DEGP_ECOLI (P09376) (474 aa) fasta scores: E(): 0, 74.9% id in 482 aa. Similar to YPO3566 (58.0% identity in 483 aa overlap); Belongs to the peptidase S1C family. (481 aa)
pcnBpoly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (440 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (705 aa)
tufA-2Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
famRNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (285 aa)
cmrSimilar to Escherichia coli multidrug translocase MdfA SW:MDFA_ECOLI (Q46966) (410 aa) fasta scores: E(): 0,73.0% id in 400 aa, and to Escherichia coli hypothetical protein YjiO SW:YJIO_ECOLI (P39386) (410 aa) fasta scores: E(): 0, 43.2% id in 377 aa. (409 aa)
atpDATP synthase beta subunit protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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