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trpA trpA rpsS rpsS rpmJ rpmJ thiQ thiQ thiP thiP leuB leuB YPO0698 YPO0698 bioA bioA bioF bioF bioC bioC bioD bioD thiK thiK zwf zwf trpB trpB trpC trpC trpD trpD trpG trpG trpE trpE sohB sohB supX supX bioD-2 bioD-2 cspE cspE cof cof pyrG pyrG pgi pgi apk apk dapF dapF dnaA dnaA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rpmJSimilar to Escherichia coli 50S ribosomal protein L36 RpmJ SW:RL36_ECOLI (P21194) (38 aa) fasta scores: E(): 2.1e-15, 94.7% id in 38 aa; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
thiQThiamine transport ATP-binding protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. (227 aa)
thiPSimilar to Escherichia coli thiamine ABC transporter, permease protein ThiP SW:THIP_ECOLI (P31549) (536 aa) fasta scores: E(): 0, 74.0% id in 516 aa, and to Vibrio cholerae putative thiamine ABC transporter, permease protein VC2538 TR:Q9KP41 (EMBL:AE004323) (530 aa) fasta scores: E(): 0, 46.5% id in 512 aa. (519 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (365 aa)
YPO0698Similar to Escherichia coli outer membrane usher protein PapC SW:PAPC_ECOLI (P07110) (836 aa) fasta scores: E(): 0, 48.4% id in 834 aa, and to Proteus mirabilis outer membrane usher protein MrpC TR:Q51904 (EMBL:Z32686) (871 aa) fasta scores: E(): 0, 45.8% id in 825 aa. (826 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (422 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (383 aa)
bioCBiotin synthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (267 aa)
bioDDethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (240 aa)
thiKConserved hypothetical protein; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (268 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpCTryptophan biosynthesis protein TrpCF; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). (475 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (333 aa)
trpGAnthranilate synthase component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (192 aa)
trpESimilar to Escherichia coli anthranilate synthase component I TrpE SW:TRPE_ECOLI (P00895) (520 aa) fasta scores: E(): 0, 76.0% id in 520 aa, and to Salmonella typhimurium anthranilate synthase component I TrpE SW:TRPE_SALTY (P00898) (520 aa) fasta scores: E(): 0, 74.4% id in 520 aa. (521 aa)
sohBPeptidase family U7 protein; Similar to Escherichia coli possible protease SohB SW:SOHB_ECOLI (P24213) (349 aa) fasta scores: E(): 0, 64.8% id in 349 aa, and to Vibrio cholerae putative U7 family peptidase VC1060 TR:Q9KT45 (EMBL:AE004187) (356 aa) fasta scores: E(): 0, 58.6% id in 353 aa. (348 aa)
supXDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (871 aa)
bioD-2Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (222 aa)
cspESimilar to Escherichia coli probable cold shock protein CspE SW:CSPE_ECOLI (P36997) (68 aa) fasta scores: E(): 1e-25, 94.1% id in 68 aa, and to Vibrio cholerae hypothetical protein TR:AAC72388 (EMBL:AF098260) (69 aa) fasta scores: E(): 3.1e-26, 94.2% id in 69 aa. Similar to YPO1746 (84.1% identity in 69 aa overlap), YPO1655 (83.3% identity in 66 aa overlap), YPO3644 (73.6% identity in 72 aa overlap), YPO3643 (72.2% identity in 72 aa overlap),YPO2659 (63.9% identity in 72 aa overlap) and YPO1398 (53.6% identity in 69 aa overlap). (69 aa)
cofPutative haloacid dehalogenase-like hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). (273 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
pgiSimilar to Escherichia coli glucose-6-phosphate isomerase Pgi SW:G6PI_ECOLI (P11537) (549 aa) fasta scores: E(): 0, 87.2% id in 548 aa, and to Vibrio cholerae glucose-6-phosphate isomerase Vc0374 TR:Q9KUY4 (EMBL:AE004125) (550 aa) fasta scores: E(): 0, 76.5% id in 548 aa. (548 aa)
apkSimilar to Escherichia coli lysine-sensitive aspartokinase III LysC or Apk SW:AK3_ECOLI (P08660) (449 aa) fasta scores: E(): 0, 81.5% id in 448 aa, and to Vibrio cholerae aspartokinase III, lysine-sensitive Vc0391 TR:Q9KUW8 (EMBL:AE004127) (479 aa) fasta scores: E(): 0,55.2% id in 453 aa; Belongs to the aspartokinase family. (461 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa)
dnaAChromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (462 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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