STRINGSTRING
mtlD mtlD xylA xylA YPO3817 YPO3817 fbp fbp YPO3480 YPO3480 YPO3479 YPO3479 rpiB rpiB ydjJ ydjJ YPO3311 YPO3311 yqaB yqaB YPO3211 YPO3211 manC manC manB-2 manB-2 YPO2855 YPO2855 YPO2562 YPO2562 gutB gutB manB manB YPO2446 YPO2446 dalD dalD manA manA YPO1991 YPO1991 gptB-2 gptB-2 manY manY gptB gptB YPO1567 YPO1567 YPO1566 YPO1566 fruA fruA fpk fpk YPO1236 YPO1236 fba fba YPO0404 YPO0404 YPO0403 YPO0403 YPO0402 YPO0402 b3904 b3904 b3903 b3903 b3902 b3902 tpi tpi pfkA pfkA YPO4108 YPO4108 mtlA mtlA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtlDSimilar to Klebsiella pneumoniae mannitol-1-phosphate 5-dehydrogenase MtlD SW:MTLD_KLEPN (Q9XBM6) (382 aa) fasta scores: E(): 0, 76.6% id in 380 aa,and to Escherichia coli mannitol-1-phosphate 5-dehydrogenase MtlD SW:MTLD_ECOLI (P09424) (382 aa) fasta scores: E(): 0, 75.7% id in 382 aa. (387 aa)
xylAXylose isomerase; Similar to Escherichia coli xylose isomerase XylA SW:XYLA_ECOLI (P00944) (440 aa) fasta scores: E(): 0, 85.4% id in 438 aa, and to Klebsiella pneumoniae xylose isomerase XylA SW:XYLA_KLEPN (P29442) (440 aa) fasta scores: E(): 0,84.2% id in 438 aa. (439 aa)
YPO3817Putative membrane protein; Similar to Escherichia coli hypothetical protein YhhM SW:YHHM_ECOLI (P37615) (119 aa) fasta scores: E(): 2.5e-08, 35.8% id in 134 aa. CDS contains and insert,residues 86 to 103, relative to the E. coli protein. (139 aa)
fbpFructose-1,6-bisphosphatase; Similar to Escherichia coli fructose-1,6-bisphosphatase Fbp or Fdp SW:F16P_ECOLI (P09200) (332 aa) fasta scores: E(): 0, 84.1% id in 333 aa,and to Vibrio cholerae fructose-1,6-bisphosphatase Vc2544 TR:Q9KP35 (EMBL:AE004323) (336 aa) fasta scores: E(): 0,73.9% id in 333 aa. (337 aa)
YPO3480Similar to Escherichia coli hypothetical protein YhbV SW:YHBV_ECOLI (P45475) (298 aa) fasta scores: E(): 0,75.9% id in 290 aa, and to Vibrio cholerae hypothetical protein VC0651 TR:Q9KU72 (EMBL:AE004151) (321 aa) fasta scores: E(): 0, 66.7% id in 288 aa. (292 aa)
YPO3479Putative protease; Similar to Proteus mirabilis STM-protease A TR:Q9ZA85 (EMBL:AF088981) (334 aa) fasta scores: E(): 0,83.8% id in 334 aa, and to Escherichia coli putative protease precursor YhbU SW:YHBU_ECOLI (P45527) (331 aa) fasta scores: E(): 0, 88.5% id in 331 aa. (331 aa)
rpiBSimilar to Escherichia coli ribose 5-phosphate isomerase B RpiB SW:RPIB_ECOLI (P37351) (149 aa) fasta scores: E(): 1.7e-22, 44.2% id in 147 aa, and to Bacillus halodurans ribose 5-phosphate epimerase Bh3767 TR:Q9K6G2 (EMBL:AP001519) (145 aa) fasta scores: E(): 7.3e-24, 44.1% id in 145 aa. (151 aa)
ydjJPutative Zinc-binding dehydrogenase; Similar to Pseudomonas putida 2,3-butanediol dehydrogenase Adh TR:Q59696 (EMBL:L35343) (362 aa) fasta scores: E(): 0, 35.5% id in 358 aa, and to Escherichia coli hypothetical zinc-type alcohol dehydrogenase-like protein in ansA-gapA intergenic region YdjJ SW:YDJJ_ECOLI (P77280) (347 aa) fasta scores: E(): 5.8e-30, 30.7% id in 348 aa. Similar to YPO2502 (52.6% identity in 361 aa overlap). (371 aa)
YPO3311Similar to Thermotoga maritima hypothetical protein TM0951 TR:Q9X048 (EMBL:AE001758) (471 aa) fasta scores: E(): 0, 51.3% id in 466 aa. (474 aa)
yqaBPutative hydrolase; Similar to Escherichia coli hypothetical 20.8 kDa protein in gshA-csrA intergenic region YqaB SW:YQAB_ECOLI (P77475) (188 aa) fasta scores: E(): 0, 67.0% id in 188 aa,and to Haemophilus influenzae hypothetical protein Hi0488 SW:YQAB_HAEIN (P44004) (200 aa) fasta scores: E(): 2.1e-31,46.8% id in 188 aa. (188 aa)
YPO3211Similar to Escherichia coli hypothetical protein YajF SW:YAJF_ECOLI (P23917) (302 aa) fasta scores: E(): 0,69.2% id in 299 aa, and to Vibrio cholerae ROK family protein Vc0270 TR:Q9KV86 (EMBL:AE004115) (326 aa) fasta scores: E(): 0, 46.3% id in 298 aa. (304 aa)
manCSimilar to Yersinia pseudotuberculosis mannose-1-phosphate guanylyltransferase ManC TR:Q9RCB1 (EMBL:AJ251712) (468 aa) fasta scores: E(): 0, 99.8% id in 468 aa, and to Yersinia enterocolitica mannose-1-phosphate guanylyltransferase RfbM or ManC TR:Q56874 (EMBL:U46859) (465 aa) fasta scores: E(): 0, 80.7% id in 462 aa, and identical to the previously sequenced Yersinia pestis mannose-1-phosphate guanylyltransferase ManC TR:Q9RCC5 (EMBL:AJ251713) (468 aa) fasta scores: E(): 0, 100.0% id in 468 aa; Belongs to the mannose-6-phosphate isomerase type 2 family. (470 aa)
manB-2Phosphomannomutase; Similar to Yersinia pseudotuberculosis phosphomannomutase ManB TR:Q9RCA9 (EMBL:AJ251712) (457 aa) fasta scores: E(): 0, 99.8% id in 457 aa, and to Yersinia enterocolitica phosphomannomutase RfbK or ManB TR:Q57439 (EMBL:U46859) (456 aa) fasta scores: E(): 0, 81.8% id in 456 aa. Identical to the previously sequenced Yersinia pestis phosphomannomutase ManB TR:Q9RCC3 (EMBL:AJ251713) (457 aa) fasta scores: E(): 0, 100.0% id in 457 aa. Similar to YPO2479 (61.4% identity in 461 aa overlap). (457 aa)
YPO2855Putative protease; Similar to Proteus mirabilis putative protease TR:Q9ZA85 (EMBL:AF088981) (334 aa) fasta scores: E(): 5.3e-19, 28.5% id in 316 aa, and to Escherichia coli putative protease YegQ SW:YEGQ_ECOLI (P76403) (453 aa) fasta scores: E(): 0, 83.4% id in 452 aa. (464 aa)
YPO2562Putative haloacid dehalogenase-like hydrolase; Similar to Saccharomyces cerevisiae DL-glycerol-3-phosphatase GPP2 SW:GPP2_YEAST (P40106) (250 aa) fasta scores: E(): 4.7e-15, 33.0% id in 212 aa, and to Escherichia coli hypothetical protein YfbT SW:YFBT_ECOLI (P77625) (222 aa) fasta scores: E(): 0, 72.4% id in 214 aa. (220 aa)
gutBPutative zinc-binding dehydrogenase; Similar to Bacillus subtilis sorbitol dehydrogenase GutB SW:DHSO_BACSU (Q06004) (352 aa) fasta scores: E(): 4.8e-31, 31.3% id in 355 aa, and to Pyrococcus horikoshii hypothetical dehydrogenase PH0655 TR:O58389 (EMBL:AP000003) (348 aa) fasta scores: E(): 1.8e-30, 34.6% id in 356 aa. (408 aa)
manBPhosphomannomutase; Similar to Escherichia coli phosphomannomutase ManB SW:RFK9_ECOLI (P37755) (456 aa) fasta scores: E(): 0, 61.5% id in 462 aa, to Salmonella montevideo phosphomannomutase ManB SW:MANB_SALMO (Q01411) (456 aa) fasta scores: E(): 0,61.4% id in 461 aa and to Yersinia pestis YPO3097 (457 aa) fasta scores: E(): 0, 61.4% identity in 461 aa overlap. (462 aa)
YPO2446Similar to Escherichia coli hypothetical protein YniC SW:YNIC_ECOLI (P77247) (222 aa) fasta scores: E(): 0,65.9% id in 220 aa. (221 aa)
dalDPutative mannitol dehydrogenase; Similar to Klebsiella pneumoniae D-arabinitol dehydrogenase DalD TR:O52720 (EMBL:AF045245) (455 aa) fasta scores: E(): 0, 64.4% id in 449 aa, and to Rhodobacter sphaeroides mannitol 2-dehydrogenase MtlK SW:MTLK_RHOSH (P33216) (476 aa) fasta scores: E(): 0, 34.0% id in 438 aa. (463 aa)
manASimilar to Escherichia coli mannose-6-phosphate isomerase ManA SW:MANA_ECOLI (P00946) (391 aa) fasta scores: E(): 0, 71.0% id in 389 aa, and to Salmonella typhimurium mannose-6-phosphate isomerase ManA SW:MANA_SALTY (P25081) (391 aa) fasta scores: E(): 0, 70.2% id in 389 aa. (391 aa)
YPO1991Putative sugar-phosphate isomerase; Similar to Escherichia coli ribose 5-phosphate isomerase B RpiB SW:RPIB_ECOLI (P37351) (149 aa) fasta scores: E(): 1.6, 28.3% id in 145 aa, and to Thermotoga maritima sugar-phosphate isomerase Tm1080 TR:Q9X0G9 (EMBL:AE001768) (143 aa) fasta scores: E(): 0.15, 32.0% id in 125 aa. (212 aa)
gptB-2Similar to Escherichia coli PTS system,mannose-specific IIAB component ManX or PtsL or GptB SW:PTNA_ECOLI (P08186) (322 aa) fasta scores: E(): 0, 81.4% id in 323 aa, and to Streptococcus salivarius mannose-specific phosphotransferase system component iiab manL TR:Q9S4L5 (EMBL:AF130465) (330 aa) fasta scores: E(): 0, 42.5% id in 332 aa. (324 aa)
manYSimilar to Escherichia coli PTS system,mannose-specific IIC component ManY or PtsP or Pel SW:PTNC_ECOLI (P08187) (266 aa) fasta scores: E(): 0, 87.7% id in 269 aa, and to Klebsiella pneumoniae PTS system,sorbose-specific IIC component SorA SW:PTRC_KLEPN (P37082) (266 aa) fasta scores: E(): 0, 61.3% id in 266 aa. (265 aa)
gptBSimilar to Escherichia coli PTS system,mannose-specific IID component ManZ or PtsM or GptB SW:PTND_ECOLI (P08188) (286 aa) fasta scores: E(): 0, 86.6% id in 291 aa, and to Bacillus subtilis PTS system,fructose-specific IID component LevG SW:PTFD_BACSU (P26382) (275 aa) fasta scores: E(): 0, 60.4% id in 273 aa. This CDS has a small insertion at the N-terminal end relative to that of E.coli. (295 aa)
YPO1567Similar to several racemases from Homo sapiens associated with quorum sensing functions in human cells e.g. RTS beta TR:Q15407 (EMBL:X89602) (416 aa) fasta scores: E(): 0, 53.1% id in 401 aa, and to Homo sapiens RTS alpha TR:AAG29536 (EMBL:AF305057) (361 aa) fasta scores: E(): 0, 54.1% id in 331 aa; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (400 aa)
YPO1566Putative hydrolase; Similar to many proposed: 2-hydroxyhepta-2,4-diene-1, 7-dioate isomerase/5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioatedecarb oxylase e.g. Rhodobacter capsulatus TR:O68122 (EMBL:AF010496) (280 aa) fasta scores: E(): 0, 56.1% id in 280 aa, and to Streptomyces coelicolor Sce20.24C TR:Q9RDA1 (EMBL:AL136058) (285 aa) fasta scores: E(): 0, 53.7% id in 285 aa. (280 aa)
fruASimilar to Escherichia coli PTS system,fructose-specific IIBC component FruA or PtsF SW:PTFB_ECOLI (P20966) (563 aa) fasta scores: E(): 0, 77.2% id in 569 aa,and to Vibrio cholerae PTS system, fructose-specific IIBC component VCA0516 TR:Q9KM72 (EMBL:AE004382) (580 aa) fasta scores: E(): 0, 65.7% id in 531 aa. (566 aa)
fpk1-phosphofructokinase; Similar to Escherichia coli 1-phosphofructokinase FruK or Fpk SW:K1PF_ECOLI (P23539) (312 aa) fasta scores: E(): 0, 92.0% id in 312 aa, and to Haemophilus influenzae 1-phosphofructokinase FruK SW:K1PF_HAEIN (P44330) (313 aa) fasta scores: E(): 0, 55.4% id in 305 aa; Belongs to the carbohydrate kinase PfkB family. (312 aa)
YPO1236Putative class II aldolase-family protein; Similar to Escherichia coli hypothetical protein YgbL SW:YGBL_ECOLI (Q46890) (212 aa) fasta scores: E(): 0,57.1% id in 168 aa, and to Escherichia coli L-fuculose phosphate aldolase FucA or FucC or Prd SW:FUCA_ECOLI (P11550) (215 aa) fasta scores: E(): 2.6e-07, 32.7% id in 159 aa. (203 aa)
fbaFructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
YPO0404PTS system, IIC component; Similar to many carbohydrate phosphotransferase IIC components e.g. part of Escherichia coli PTS system,fructose-specific IIBC component FruA SW:PTFB_ECOLI (P20966) (563 aa) fasta scores: E(): 0, 40.7% id in 329 aa and to Escherichia coli PTS system, fructose-like-2 IIC component FrwC SW:PTWC_ECOLI (P32672) (359 aa) fasta scores: E(): 0, 76.5% id in 358 aa. (361 aa)
YPO0403PTS system, IIB component; Similar to many carbohydrate phosphotransferase IIB components e.g. Escherichia coli PTS system,fructose-like-2 IIB component 1 FrwB, SW:PTWB_ECOLI (P32673) (106 aa) fasta scores: E(): 0, 82.7% id in 104 aa. Similar to part of Rhodobacter capsulatus PTS system,fructose-specific IIBC component FruA SW:PTFB_RHOCA (P23387) (578 aa) fasta scores: E(): 6.3e-16, 47.4% id in 97 aa and to Escherichia coli PTS system, fructose-specific IIBC component FruA, PtsF, SW:PTFB_ECOLI (P20966) (563 aa) fasta scores: E(): 1e-15, 49.5% id in 97 aa. (106 aa)
YPO0402PTS system, IIB component; Similar to many carbohydrate phosphotransferase system IIB components e.g. Escherichia coli PTS system,fructose-like-2 IIB component 2 FrwD SW:PTWX_ECOLI (P32676) (113 aa) fasta scores: E(): 3.2e-23, 52.7% id in 110 aa. (114 aa)
b3904Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Belongs to the rhamnulokinase family. (485 aa)
b3903Similar to Escherichia coli L-rhamnose isomerase RhaA SW:RHAA_ECOLI (P32170) (419 aa) fasta scores: E(): 0,85.2% id in 418 aa. (418 aa)
b3902Rhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Belongs to the aldolase class II family. RhaD subfamily. (274 aa)
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
YPO4108Putative haloacid dehalogenase-like hydrolase; Similar to Escherichia coli hypothetical protein YieH SW:YIEH_ECOLI (P31467) (221 aa) fasta scores: E(): 0,62.3% id in 220 aa, and to Vibrio cholerae CbbY family protein VCA0798 TR:Q9KLE8 (EMBL:AE004407) (226 aa) fasta scores: E(): 3e-26, 35.1% id in 211 aa. (222 aa)
mtlASimilar to Escherichia coli PTS system,mannitol-specific IIABC component MtlA SW:PTMA_ECOLI (P00550) (637 aa) fasta scores: E(): 0, 81.7% id in 638 aa,and to Klebsiella pneumoniae PTS system, mannitol-specific IIABC component MtlA SW:PTMA_KLEPN (Q9XBM7) (635 aa) fasta scores: E(): 0, 81.1% id in 635 aa. (643 aa)
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.