(20 nodes) MAPK cascade, and Phosphorelay signal transduction system network (Cryptococcus neoformans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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Your Input:
	A0A0S2M685	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. (297 aa)
	CPK1	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets. (366 aa)
	Q5K7A9_CRYNJ	Expressed protein. (614 aa)
	Q5K7R5_CRYNJ	Transferase, putative. (209 aa)
	Q5K8I5_CRYNJ	MAP kinase kinase kinase. (1486 aa)
	Q5K8S3_CRYNJ	Protein-tyrosine-phosphatase, putative. (1212 aa)
	Q5KAF9_CRYNJ	Map kinase kinase kinase mkh1, putative. (1791 aa)
	Q5KBG0_CRYNJ	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (807 aa)
	Q5KC34_CRYNJ	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (426 aa)
	Q5KGY3_CRYNJ	Mitogen-activated protein kinase kinase, putative. (621 aa)
	Q5KHE5_CRYNJ	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (401 aa)
	Q5KHP1_CRYNJ	Uncharacterized protein. (874 aa)
	Q5KHP6_CRYNJ	Ste11alpha protein. (1230 aa)
	Q5KHZ8_CRYNJ	Uncharacterized protein. (324 aa)
	Q5KJP5_CRYNJ	Protein kinase regulator, putative. (700 aa)
	Q5KKP1_CRYNJ	MAP kinase kinase, putative. (462 aa)
	Q5KLL7_CRYNJ	Transcriptional activator, putative. (548 aa)
	Q5KM40_CRYNJ	Two-component response regulator, putative. (1337 aa)
	Q5KN75_CRYNJ	MAP kinase kinase, putative. (609 aa)
	Q5KQ00_CRYNJ	Two-component sensor molecule, putative. (1211 aa)

Your Current Organism:

Cryptococcus neoformans

NCBI taxonomy Id: 214684
Other names: C. neoformans var. neoformans JEC21, Cryptococcus neoformans JEC21, Cryptococcus neoformans var. neoformans JEC21, Cryptococcus neoformans var. neoformans serotype D JEC21, Cryptococcus neoformans var. neoformans strain JEC21, Filobasidiella neoformans var. neoformans strain JEC21

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0S2M685	Q5K7A9_CRYNJ	A0A0S2M685	Q5K7A9	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Expressed protein.	0.665
A0A0S2M685	Q5K7R5_CRYNJ	A0A0S2M685	Q5K7R5	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Transferase, putative.	0.535
A0A0S2M685	Q5K8I5_CRYNJ	A0A0S2M685	Q5K8I5	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	MAP kinase kinase kinase.	0.583
A0A0S2M685	Q5K8S3_CRYNJ	A0A0S2M685	Q5K8S3	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Protein-tyrosine-phosphatase, putative.	0.434
A0A0S2M685	Q5KAF9_CRYNJ	A0A0S2M685	Q5KAF9	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Map kinase kinase kinase mkh1, putative.	0.459
A0A0S2M685	Q5KGY3_CRYNJ	A0A0S2M685	Q5KGY3	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Mitogen-activated protein kinase kinase, putative.	0.528
A0A0S2M685	Q5KHP6_CRYNJ	A0A0S2M685	Q5KHP6	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Ste11alpha protein.	0.969
A0A0S2M685	Q5KJP5_CRYNJ	A0A0S2M685	Q5KJP5	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Protein kinase regulator, putative.	0.965
A0A0S2M685	Q5KKP1_CRYNJ	A0A0S2M685	Q5KKP1	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	MAP kinase kinase, putative.	0.698
A0A0S2M685	Q5KM40_CRYNJ	A0A0S2M685	Q5KM40	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Two-component response regulator, putative.	0.765
A0A0S2M685	Q5KN75_CRYNJ	A0A0S2M685	Q5KN75	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	MAP kinase kinase, putative.	0.995
A0A0S2M685	Q5KQ00_CRYNJ	A0A0S2M685	Q5KQ00	SH3 domain-containing protein; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.	Two-component sensor molecule, putative.	0.639
CPK1	Q5K8I5_CRYNJ	P0CP66	Q5K8I5	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	MAP kinase kinase kinase.	0.432
CPK1	Q5K8S3_CRYNJ	P0CP66	Q5K8S3	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	Protein-tyrosine-phosphatase, putative.	0.957
CPK1	Q5KAF9_CRYNJ	P0CP66	Q5KAF9	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	Map kinase kinase kinase mkh1, putative.	0.491
CPK1	Q5KGY3_CRYNJ	P0CP66	Q5KGY3	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	Mitogen-activated protein kinase kinase, putative.	0.668
CPK1	Q5KHE5_CRYNJ	P0CP66	Q5KHE5	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.901
CPK1	Q5KHP1_CRYNJ	P0CP66	Q5KHP1	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	Uncharacterized protein.	0.974
CPK1	Q5KHP6_CRYNJ	P0CP66	Q5KHP6	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	Ste11alpha protein.	0.670
CPK1	Q5KHZ8_CRYNJ	P0CP66	Q5KHZ8	Mitogen-activated protein kinase CPK1; Responds to activation by environmental stress by phosphorylating downstream targets.	Uncharacterized protein.	0.703

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