node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DFR1 | Q5K7B2_CRYNJ | Q07801 | Q5K7B2 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.916 |
DFR1 | Q5K8Q9_CRYNJ | Q07801 | Q5K8Q9 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.621 |
DFR1 | Q5KAU8_CRYNJ | Q07801 | Q5KAU8 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.992 |
DFR1 | Q5KCY2_CRYNJ | Q07801 | Q5KCY2 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Dihydrofolate synthase, putative. | 0.988 |
DFR1 | Q5KEG6_CRYNJ | Q07801 | Q5KEG6 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Folic acid and derivative metabolism-related protein, putative. | 0.983 |
DFR1 | Q5KEZ0_CRYNJ | Q07801 | Q5KEZ0 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NAD+), putative. | 0.901 |
DFR1 | Q5KJH4_CRYNJ | Q07801 | Q5KJH4 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | FSH1 domain-containing protein. | 0.958 |
DFR1 | Q5KJZ3_CRYNJ | Q07801 | Q5KJZ3 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.988 |
DFR1 | Q5KK40_CRYNJ | Q07801 | Q5KK40 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.986 |
DFR1 | Q5KK71_CRYNJ | Q07801 | Q5KK71 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Folic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family. In the central section; belongs to the HPPK family. | 0.650 |
DFR1 | Q5KL19_CRYNJ | Q07801 | Q5KL19 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.916 |
DFR1 | Q5KN82_CRYNJ | Q07801 | Q5KN82 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.621 |
DFR1 | TMP1 | Q07801 | P0CS12 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | Thymidylate synthase. | 0.999 |
Q5K7B2_CRYNJ | DFR1 | Q5K7B2 | Q07801 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. | 0.916 |
Q5K7B2_CRYNJ | Q5K8Q9_CRYNJ | Q5K7B2 | Q5K8Q9 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.761 |
Q5K7B2_CRYNJ | Q5KAU8_CRYNJ | Q5K7B2 | Q5KAU8 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.992 |
Q5K7B2_CRYNJ | Q5KEG6_CRYNJ | Q5K7B2 | Q5KEG6 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Folic acid and derivative metabolism-related protein, putative. | 0.707 |
Q5K7B2_CRYNJ | Q5KEZ0_CRYNJ | Q5K7B2 | Q5KEZ0 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Methylenetetrahydrofolate dehydrogenase (NAD+), putative. | 0.904 |
Q5K7B2_CRYNJ | Q5KJH4_CRYNJ | Q5K7B2 | Q5KJH4 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | FSH1 domain-containing protein. | 0.722 |
Q5K7B2_CRYNJ | Q5KK40_CRYNJ | Q5K7B2 | Q5KK40 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.999 |