STRINGSTRING
Q5KK78_CRYNJ Q5KK78_CRYNJ COQ5 COQ5 Q5KP02_CRYNJ Q5KP02_CRYNJ Q5KNN2_CRYNJ Q5KNN2_CRYNJ Q5KN82_CRYNJ Q5KN82_CRYNJ Q5KN20_CRYNJ Q5KN20_CRYNJ Q5KML0_CRYNJ Q5KML0_CRYNJ Q5KMA7_CRYNJ Q5KMA7_CRYNJ Q5KLT9_CRYNJ Q5KLT9_CRYNJ Q5KLK7_CRYNJ Q5KLK7_CRYNJ Q5KLA9_CRYNJ Q5KLA9_CRYNJ Q5KL46_CRYNJ Q5KL46_CRYNJ Q5KKZ6_CRYNJ Q5KKZ6_CRYNJ Q5KKU8_CRYNJ Q5KKU8_CRYNJ Q5KKU4_CRYNJ Q5KKU4_CRYNJ Q5KKT5_CRYNJ Q5KKT5_CRYNJ Q5KKL6_CRYNJ Q5KKL6_CRYNJ Q5KKJ7_CRYNJ Q5KKJ7_CRYNJ Q5KK70_CRYNJ Q5KK70_CRYNJ Q5KK01_CRYNJ Q5KK01_CRYNJ Q5KJZ6_CRYNJ Q5KJZ6_CRYNJ Q5KJZ3_CRYNJ Q5KJZ3_CRYNJ Q5KJP0_CRYNJ Q5KJP0_CRYNJ Q5KJH5_CRYNJ Q5KJH5_CRYNJ Q5KJH4_CRYNJ Q5KJH4_CRYNJ Q5KJH3_CRYNJ Q5KJH3_CRYNJ Q5KJ65_CRYNJ Q5KJ65_CRYNJ NNRE_CRYNJ NNRE_CRYNJ UBA4 UBA4 COQ7 COQ7 Q5KIY3_CRYNJ Q5KIY3_CRYNJ Q5KIS7_CRYNJ Q5KIS7_CRYNJ Q5KI37_CRYNJ Q5KI37_CRYNJ Q5KHR6_CRYNJ Q5KHR6_CRYNJ Q5KHM2_CRYNJ Q5KHM2_CRYNJ Q5KGT6_CRYNJ Q5KGT6_CRYNJ Q5KGL6_CRYNJ Q5KGL6_CRYNJ Q5KFW8_CRYNJ Q5KFW8_CRYNJ Q5KFT2_CRYNJ Q5KFT2_CRYNJ Q5KFC9_CRYNJ Q5KFC9_CRYNJ Q5KF79_CRYNJ Q5KF79_CRYNJ Q5KEZ0_CRYNJ Q5KEZ0_CRYNJ Q5KEW3_CRYNJ Q5KEW3_CRYNJ Q5KEL6_CRYNJ Q5KEL6_CRYNJ Q5KEG6_CRYNJ Q5KEG6_CRYNJ Q5KE49_CRYNJ Q5KE49_CRYNJ Q5KE34_CRYNJ Q5KE34_CRYNJ Q5KDF7_CRYNJ Q5KDF7_CRYNJ Q5KDC3_CRYNJ Q5KDC3_CRYNJ Q5KD66_CRYNJ Q5KD66_CRYNJ Q5KCY2_CRYNJ Q5KCY2_CRYNJ Q5KCS0_CRYNJ Q5KCS0_CRYNJ Q5KCH8_CRYNJ Q5KCH8_CRYNJ Q5KCD7_CRYNJ Q5KCD7_CRYNJ Q5KBW1_CRYNJ Q5KBW1_CRYNJ Q5KBV8_CRYNJ Q5KBV8_CRYNJ Q5KBQ7_CRYNJ Q5KBQ7_CRYNJ Q5KBJ5_CRYNJ Q5KBJ5_CRYNJ Q5KBJ2_CRYNJ Q5KBJ2_CRYNJ COQ6 COQ6 Q5KAU8_CRYNJ Q5KAU8_CRYNJ Q5KAE7_CRYNJ Q5KAE7_CRYNJ COQ3 COQ3 Q5K9C8_CRYNJ Q5K9C8_CRYNJ Q5K9B2_CRYNJ Q5K9B2_CRYNJ Q5K909_CRYNJ Q5K909_CRYNJ Q5K8W6_CRYNJ Q5K8W6_CRYNJ Q5K8Q9_CRYNJ Q5K8Q9_CRYNJ Q5K8P0_CRYNJ Q5K8P0_CRYNJ NNRD_CRYNJ NNRD_CRYNJ Q5K8E9_CRYNJ Q5K8E9_CRYNJ Q5K7R6_CRYNJ Q5K7R6_CRYNJ DFR1 DFR1 A0A0S2M612 A0A0S2M612 A0A0S2M5Y1 A0A0S2M5Y1 A0A0S2LHZ7 A0A0S2LHZ7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q5KK78_CRYNJNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (301 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (323 aa)
Q5KP02_CRYNJExpressed protein. (427 aa)
Q5KNN2_CRYNJRIBOSOMAL_L9 domain-containing protein. (215 aa)
Q5KN82_CRYNJMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (633 aa)
Q5KN20_CRYNJTransporter, putative; Belongs to the mitochondrial carrier (TC 2.A.29) family. (386 aa)
Q5KML0_CRYNJExpressed protein. (248 aa)
Q5KMA7_CRYNJPantetheine-phosphate adenylyltransferase, putative. (362 aa)
Q5KLT9_CRYNJIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
Q5KLK7_CRYNJGTP cyclohydrolase I, putative. (435 aa)
Q5KLA9_CRYNJUncharacterized protein. (540 aa)
Q5KL46_CRYNJBiotin-[acetyl-CoA-carboxylase] ligase, putative. (789 aa)
Q5KKZ6_CRYNJExpressed protein. (540 aa)
Q5KKU8_CRYNJ4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (373 aa)
Q5KKU4_CRYNJAcetyl/propionyl CoA carboxylase, beta subunit, putative. (597 aa)
Q5KKT5_CRYNJMethylcrotonoyl-Coenzyme A carboxylase 1, putative. (733 aa)
Q5KKL6_CRYNJVacuolar membrane protein, putative; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (443 aa)
Q5KKJ7_CRYNJExpressed protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (319 aa)
Q5KK70_CRYNJDephospho-CoA kinase, putative. (283 aa)
Q5KK01_CRYNJNADH kinase, putative. (390 aa)
Q5KJZ6_CRYNJPantothenate kinase, putative. (526 aa)
Q5KJZ3_CRYNJFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (497 aa)
Q5KJP0_CRYNJRiboflavin kinase, putative. (242 aa)
Q5KJH5_CRYNJUncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (378 aa)
Q5KJH4_CRYNJFSH1 domain-containing protein. (301 aa)
Q5KJH3_CRYNJExpressed protein. (312 aa)
Q5KJ65_CRYNJProtein phosphatase inhibitor, putative. (368 aa)
NNRE_CRYNJNAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (249 aa)
UBA4Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] (415 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (251 aa)
Q5KIY3_CRYNJNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (741 aa)
Q5KIS7_CRYNJVacuolar membrane protein, putative; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (455 aa)
Q5KI37_CRYNJVacuolar protein, putative. (605 aa)
Q5KHR6_CRYNJCysteine desulfhydrase, putative. (502 aa)
Q5KHM2_CRYNJNucleoside transporter. (618 aa)
Q5KGT6_CRYNJMoCF_biosynth domain-containing protein. (337 aa)
Q5KGL6_CRYNJPhosphopantothenate-cysteine ligase, putative. (367 aa)
Q5KFW8_CRYNJNicotinate-nucleotide adenylyltransferase, putative. (544 aa)
Q5KFT2_CRYNJPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1103 aa)
Q5KFC9_CRYNJAcetyl-CoA carboxylase, putative. (2237 aa)
Q5KF79_CRYNJExpressed protein. (311 aa)
Q5KEZ0_CRYNJMethylenetetrahydrofolate dehydrogenase (NAD+), putative. (367 aa)
Q5KEW3_CRYNJUncharacterized protein. (788 aa)
Q5KEL6_CRYNJExpressed protein. (331 aa)
Q5KEG6_CRYNJFolic acid and derivative metabolism-related protein, putative. (1021 aa)
Q5KE49_CRYNJCytoplasm protein, putative. (261 aa)
Q5KE34_CRYNJNAD+ diphosphatase, putative. (474 aa)
Q5KDF7_CRYNJFlavin-adenine dinucleotide transporter, putative; Belongs to the mitochondrial carrier (TC 2.A.29) family. (339 aa)
Q5KDC3_CRYNJExpressed protein. (967 aa)
Q5KD66_CRYNJCoenzyme A transporter, putative; Belongs to the mitochondrial carrier (TC 2.A.29) family. (381 aa)
Q5KCY2_CRYNJDihydrofolate synthase, putative. (536 aa)
Q5KCS0_CRYNJCytochrome b5, putative; Belongs to the cytochrome b5 family. (158 aa)
Q5KCH8_CRYNJPyridoxamine-phosphate oxidase, putative. (268 aa)
Q5KCD7_CRYNJMacro domain-containing protein. (252 aa)
Q5KBW1_CRYNJThiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (229 aa)
Q5KBV8_CRYNJPRK domain-containing protein. (267 aa)
Q5KBQ7_CRYNJTrans-hexaprenyltranstransferase, putative; Belongs to the FPP/GGPP synthase family. (483 aa)
Q5KBJ5_CRYNJNAD+ kinase, putative. (926 aa)
Q5KBJ2_CRYNJUncharacterized protein. (545 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (605 aa)
Q5KAU8_CRYNJSerine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (499 aa)
Q5KAE7_CRYNJExpressed protein. (965 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (344 aa)
Q5K9C8_CRYNJNudix hydrolase domain-containing protein. (357 aa)
Q5K9B2_CRYNJGlutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (713 aa)
Q5K909_CRYNJFMN adenylyltransferase, putative. (302 aa)
Q5K8W6_CRYNJBud site selection-related protein, putative. (402 aa)
Q5K8Q9_CRYNJMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (617 aa)
Q5K8P0_CRYNJNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (453 aa)
NNRD_CRYNJATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (363 aa)
Q5K8E9_CRYNJUncharacterized protein. (141 aa)
Q5K7R6_CRYNJChaperone, putative. (700 aa)
DFR1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family. (229 aa)
A0A0S2M612Nudix hydrolase domain-containing protein. (384 aa)
A0A0S2M5Y1Uncharacterized protein. (240 aa)
A0A0S2LHZ7Uncharacterized protein. (251 aa)
Your Current Organism:
Cryptococcus neoformans
NCBI taxonomy Id: 214684
Other names: C. neoformans var. neoformans JEC21, Cryptococcus neoformans JEC21, Cryptococcus neoformans var. neoformans JEC21, Cryptococcus neoformans var. neoformans serotype D JEC21, Cryptococcus neoformans var. neoformans strain JEC21, Filobasidiella neoformans var. neoformans strain JEC21
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