Your Input: | |
| | nikR2 | Nickel responsive transcriptional regulator NikR2; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (131 aa) |
| | sfsA | Sugar fermentation stimulation protein SfsA; Belongs to the SfsA family. (257 aa) |
| | BRM9_0114 | TetR family transcriptional regulator. (179 aa) |
| | BRM9_0127 | Hypothetical protein. (186 aa) |
| | fwdH | Formylmethanofuran dehydrogenase subunit H FwdH. (154 aa) |
| | truD | tRNA pseudouridine synthase D TruD; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (396 aa) |
| | polD2 | DNA polymerase large subunit DP2 PolD2; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1108 aa) |
| | BRM9_0146 | Transcriptional regulator with CBS domains. (297 aa) |
| | BRM9_0149 | Hypothetical protein. (131 aa) |
| | lysS | lysyl-tRNA synthetase LysS; Belongs to the class-I aminoacyl-tRNA synthetase family. (525 aa) |
| | BRM9_0182 | TrmB family transcriptional regulator. (271 aa) |
| | BRM9_0184 | Transposase. (326 aa) |
| | nrpR | Transcriptional repressor of nif and glnA operons NrpR. (564 aa) |
| | BRM9_0249 | TetR family transcriptional regulator. (211 aa) |
| | mutM1 | formamidopyrimidine-DNA glycosylase MutM1. (270 aa) |
| | BRM9_0262 | Hypothetical protein. (125 aa) |
| | BRM9_0275 | Transcription elongation factor NusA-like protein. (166 aa) |
| | hsdR | Type I restriction-modification system R subunit HsdR. (900 aa) |
| | hsdM | Type I restriction-modification system M subunit HsdM. (514 aa) |
| | BRM9_0286 | Phage integrase family protein. (397 aa) |
| | hsdS | Type I restriction-modification system S ubunit HsdS. (424 aa) |
| | polB1 | DNA polymerase family B PolB1. (623 aa) |
| | flpA | Fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (225 aa) |
| | BRM9_0319 | pre-mRNA splicing ribonucleoprotein PRP31. (402 aa) |
| | hjc | Archaeal Holliday junction resolvase Hjc; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (135 aa) |
| | BRM9_0328 | CBS domain-containing protein. (267 aa) |
| | BRM9_0345 | RNA-metabolising metallo-beta-lactamase. (634 aa) |
| | BRM9_0350 | Transposase. (350 aa) |
| | rnj | RNA-metabolising metallo-beta-lactamase; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (449 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K RpoK; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (58 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N RpoN. (55 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D RpoD; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (266 aa) |
| | rps11p | Ribosomal protein S11P Rps11p; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (132 aa) |
| | rps4p | Ribosomal protein S4P Rps4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (193 aa) |
| | rps13 | Ribosomal protein S13P Rps13p; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (150 aa) |
| | cbf5p | H/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (320 aa) |
| | rpl15 | Ribosomal protein L15P Rpl15p; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (145 aa) |
| | rps5p | Ribosomal protein S5P Rps5p; With S4 and S12 plays an important role in translational accuracy. (215 aa) |
| | rpl18p | Ribosomal protein L18P Rpl18p; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (193 aa) |
| | rpl19e | Ribosomal protein L19e Rpl19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa) |
| | rpl6p | Ribosomal protein L6P Rpl6p; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa) |
| | rps8p | Ribosomal protein S8P Rps8p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rps14 | Ribosomal protein S14P Rps14p; Binds 16S rRNA, required for the assembly of 30S particles. (50 aa) |
| | rpl5p | Ribosomal protein L5P Rpl5p; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (173 aa) |
| | rps4e | Ribosomal protein S4e Rps4e; Belongs to the eukaryotic ribosomal protein eS4 family. (241 aa) |
| | rpl24 | Ribosomal protein L24P Rpl24p; Located at the polypeptide exit tunnel on the outside of the subunit. (117 aa) |
| | rpl14p | Ribosomal protein L14P Rpl14p; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa) |
| | rps17 | Ribosomal protein S17P Rps17p; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (107 aa) |
| | rnp1 | Ribonuclease P subunit P29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (94 aa) |
| | BRM9_0399 | Translation initiation factor aSUI1; Belongs to the SUI1 family. (101 aa) |
| | rps3p | Ribosomal protein S3P Rps3p; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (410 aa) |
| | rpl22p | Ribosomal protein L22P Rpl22p; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (154 aa) |
| | rps19 | Ribosomal protein S19P Rps19p; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa) |
| | rpl2p | Ribosomal protein L2P Rpl2p; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (241 aa) |
| | rpl23 | Ribosomal protein L23P Rpl23p; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa) |
| | rpl4p | Ribosomal protein L4p Rpl4p; Forms part of the polypeptide exit tunnel. (262 aa) |
| | rpl3p | Ribosomal protein L3P Rpl3p; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (336 aa) |
| | BRM9_0423 | TetR family transcriptional regulator. (214 aa) |
| | BRM9_0443 | RNA-binding protein. (673 aa) |
| | dam | DNA adenine methylase Dam. (314 aa) |
| | BRM9_0525 | PadR-like family transcriptional regulator. (181 aa) |
| | BRM9_0543 | RNA methyltransferase TrmH family. (230 aa) |
| | rfcS | Replication factor C small subunit RfcS; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (321 aa) |
| | BRM9_0569 | AsnC family transcriptional regulator. (145 aa) |
| | BRM9_0577 | Transposase. (330 aa) |
| | BRM9_0589 | PIN domain-containing protein. (622 aa) |
| | endA | tRNA intron endonuclease EndA. (170 aa) |
| | hfoB | Archaeal histone B HfoB; Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro). (67 aa) |
| | rpl7ae | Ribosomal protein L7Ae Rpl7ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa) |
| | rpl24e | Ribosomal protein L24e Rpl24e; Binds to the 23S rRNA. (53 aa) |
| | infB | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (592 aa) |
| | eif2g | Translation initiation factor aIF-2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (408 aa) |
| | rpoE1 | DNA-directed RNA polymerase subunit E' RpoE1. (194 aa) |
| | BRM9_0615 | Hypothetical protein. (64 aa) |
| | hfoA1 | Archaeal histone A1 HfoA1; Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro). (68 aa) |
| | BRM9_0628 | Transposase. (132 aa) |
| | BRM9_0629 | Transposase. (227 aa) |
| | radB | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (232 aa) |
| | BRM9_0632 | Sua5/YciO/YrdC/YwlC family translation factor. (206 aa) |
| | BRM9_0646 | Transposase. (350 aa) |
| | mutM2 | formamidopyrimidine-DNA glycosylase MutM2. (260 aa) |
| | rplX | Ribosomal protein LX RplX. (76 aa) |
| | eif6 | Translation initiation factor aIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (224 aa) |
| | BRM9_0708 | DNA-binding protein; Belongs to the PDCD5 family. (116 aa) |
| | BRM9_0710 | RNA-binding protein. (78 aa) |
| | BRM9_0717 | HTH domain-containing protein. (66 aa) |
| | topA | DNA topoisomerase I TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] (718 aa) |
| | mcm | Replicative DNA helicase Mcm; Belongs to the MCM family. (670 aa) |
| | eif2b | Translation initiation factor aIF-2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (135 aa) |
| | mutS2 | DNA mismatch repair ATPase MutS family; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (631 aa) |
| | BRM9_0753 | HxlR family transcriptional regulator. (130 aa) |
| | BRM9_0767 | PP-loop family protein. (309 aa) |
| | phoU2 | Phosphate uptake regulator PhoU2. (300 aa) |
| | ef1b | Translation elongation factor aEF-1 beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (89 aa) |
| | BRM9_0817 | tRNA binding domain-containing protein. (240 aa) |
| | BRM9_0825 | HTH domain-containing protein. (318 aa) |
| | BRM9_0857 | Metallo-beta-lactamase superfamily protein. (453 aa) |
| | BRM9_0860 | Histidine kinase/PAS domain-containing protein. (577 aa) |
| | BRM9_0869 | Transcriptional regulator effector-binding domain protein. (152 aa) |
| | BRM9_0870 | PadR-like family transcriptional regulator. (182 aa) |
| | uspA1 | Universal stress protein UspA1. (143 aa) |
| | BRM9_0952 | TRAM domain-containing protein. (71 aa) |
| | BRM9_0956 | GTP-binding protein. (530 aa) |
| | BRM9_0957 | PP-loop family protein. (287 aa) |
| | trm1 | N2,N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (388 aa) |
| | BRM9_0969 | AsnC family transcriptional regulator. (160 aa) |
| | BRM9_0978 | Two component system histidine kinase. (672 aa) |
| | BRM9_0979 | Transposase. (350 aa) |
| | BRM9_0987 | Transposase. (322 aa) |
| | BRM9_1009 | Archaea-specific RecJ-like exonuclease. (724 aa) |
| | nth1 | Endonuclease III Nth1; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa) |
| | pheT | phenylalanyl-tRNA synthetase subunit beta PheT. (556 aa) |
| | BRM9_1019 | Transposase. (330 aa) |
| | BRM9_1031 | Transposase. (330 aa) |
| | nikR1 | Nickel responsive transcriptional regulator NikR1. (130 aa) |
| | uspA2 | Universal stress protein UspA2. (133 aa) |
| | tgtA2 | Archaeosine tRNA-ribosyltransferase TgtA2; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (672 aa) |
| | nac | Nascent polypeptide-associated complex protein; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family. (117 aa) |
| | BRM9_1123 | RNA-metabolising metallo-beta-lactamase. (502 aa) |
| | BRM9_1139 | Histidine kinase/PAS domain-containing protein. (674 aa) |
| | BRM9_1158 | ATP-dependent DNA helicase UvrD/REP family. (771 aa) |
| | BRM9_1162 | Virulence factor RhuM protein. (195 aa) |
| | BRM9_1167 | DEAD/DEAH box helicase domain-containing protein. (1579 aa) |
| | BRM9_1171 | Hypothetical protein. (197 aa) |
| | BRM9_1182 | ATP-dependent DNA helicase. (587 aa) |
| | BRM9_1185 | Hypothetical protein. (78 aa) |
| | BRM9_1197 | DEAD/DEAH box helicase domain-containing protein. (938 aa) |
| | rnc | Ribonuclease III Rnc. (219 aa) |
| | uspA3 | Universal stress protein UspA3. (152 aa) |
| | BRM9_1213 | AbrB family transcriptional regulator. (73 aa) |
| | BRM9_1216 | Transposase. (322 aa) |
| | BRM9_1219 | HxlR family transcriptional regulator. (126 aa) |
| | BRM9_1223 | Response regulator domain-containing protein. (288 aa) |
| | BRM9_1235 | Transposase. (350 aa) |
| | nucS | Hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (256 aa) |
| | BRM9_1251 | Iron-dependent repressor. (153 aa) |
| | aspS | aspartyl-tRNA synthetase AspS; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (439 aa) |
| | cca | tRNA nucleotidyltransferase Cca; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (466 aa) |
| | metG | methionyl-tRNA synthetase MetG; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (674 aa) |
| | BRM9_1282 | Hypothetical protein. (167 aa) |
| | BRM9_1289 | Transposase. (330 aa) |
| | BRM9_1292 | RNA-binding protein. (207 aa) |
| | thiI | Thiamine biosynthesis ATP pyrophosphatase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (384 aa) |
| | BRM9_1370 | HTH domain-containing protein. (125 aa) |
| | uvrC | Excinuclease ABC C subunit UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (622 aa) |
| | uvrB | Excinuclease ABC B subunit UvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissoc [...] (651 aa) |
| | uvrA | Excinuclease ABC A subunit UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (977 aa) |
| | BRM9_1406 | Histidine kinase/PAS domain-containing protein. (588 aa) |
| | BRM9_1407 | Response regulator domain-containing protein. (296 aa) |
| | nth2 | Endonuclease III Nth2. (231 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha subunit PheS; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (514 aa) |
| | BRM9_1421 | DEAD/DEAH box helicase domain-containing protein. (859 aa) |
| | cas1-2 | CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (321 aa) |
| | BRM9_1438 | CRISPR-associated helicase Cas3. (813 aa) |
| | BRM9_1440 | CRISPR-associated protein Cas5. (216 aa) |
| | BRM9_1441 | CRISPR-associated regulatory protein DevR family. (311 aa) |
| | BRM9_1445 | Exonuclease-like protein. (319 aa) |
| | BRM9_1446 | PHP domain-containing protein. (568 aa) |
| | BRM9_1453 | Rhodanese domain-containing protein. (117 aa) |
| | BRM9_1458 | TetR family transcriptional regulator. (211 aa) |
| | hel308 | DEAD/DEAH box helicase domain-containing protein; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (693 aa) |
| | BRM9_1482 | TetR family transcriptional regulator. (195 aa) |
| | BRM9_1485 | Histone acetyltransferase ELP3 family. (541 aa) |
| | hfoA2 | Archaeal histone A2 HfoA2; Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro). (96 aa) |
| | BRM9_1498 | Hypothetical protein. (208 aa) |
| | truA | tRNA pseudouridine synthase A TruA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (270 aa) |
| | BRM9_1532 | TRAM domain-containing protein. (74 aa) |
| | BRM9_1533 | TRAM domain-containing protein. (74 aa) |
| | BRM9_1537 | Transcriptional regulator with CBS domains. (293 aa) |
| | BRM9_1542 | Phage integrase family protein. (375 aa) |
| | BRM9_1549 | Hypothetical protein. (324 aa) |
| | BRM9_1556 | Transposase. (330 aa) |
| | ligD | DNA ligase LigD. (295 aa) |
| | BRM9_1589 | Ku protein. (255 aa) |
| | BRM9_1603 | RNA-binding protein. (304 aa) |
| | BRM9_1606 | DEAD/DEAH box helicase domain-containing protein. (829 aa) |
| | BRM9_1610 | HTH and cupin domain-containing protein. (194 aa) |
| | srp19 | Signal recognition particle SRP19 protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (97 aa) |
| | recJ2 | ssDNA exonuclease RecJ2. (465 aa) |
| | BRM9_1620 | MarR family transcriptional regulator. (266 aa) |
| | polB2 | DNA polymerase family B PolB2. (218 aa) |
| | BRM9_1642 | Phage integrase. (400 aa) |
| | lon | ATP-dependent protease S16 family; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (792 aa) |
| | BRM9_1732 | Ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome. (171 aa) |
| | BRM9_1733 | DNA-directed RNA polymerase subunit P RpoP. (43 aa) |
| | rpl37ae | Ribosomal protein L37Ae Rpl37ae; Binds to the 23S rRNA. (89 aa) |
| | rrp4 | Exosome complex RNA-binding protein Rrp4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (244 aa) |
| | BRM9_1742 | Exosome subunit. (140 aa) |
| | cshA | DEAD/DEAH box helicase domain-containing protein; Belongs to the DEAD box helicase family. (526 aa) |
| | uspA4 | Universal stress protein UspA4. (149 aa) |
| | nikR3 | Nickel responsive transcriptional regulator NikR3; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (134 aa) |
| | BRM9_1787 | HTH domain-containing protein. (156 aa) |
| | BRM9_1796 | Transposase. (350 aa) |
| | uspA5 | Universal stress protein UspA5. (148 aa) |
| | tfe | Transcription initiation factor TFIIE alpha subunit Tfe; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabili [...] (161 aa) |
| | spt5 | Ribosomal protein L24 family; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (147 aa) |
| | rpl11p | Ribosomal protein L11P Rpl11p; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (162 aa) |
| | rpl1p | Ribosomal protein L1P Rpl1p; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa) |
| | rplP0 | Acidic ribosomal protein P0 RplPO; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (335 aa) |
| | alaS | alanyl-tRNA synthetase AlaS; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (909 aa) |
| | BRM9_1843 | HTH domain-containing protein. (65 aa) |
| | phrB | Deoxyribodipyrimidine photolyase PhrB. (453 aa) |
| | BRM9_1868 | PadR-like family transcriptional regulator. (100 aa) |
| | xerA | Phage integrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Belongs to the 'phage' integrase family. XerA subfamily. (331 aa) |
| | dnaG | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (387 aa) |
| | BRM9_1898 | CRISPR-associated protein Cas5. (278 aa) |
| | BRM9_1899 | CRISPR-associated helicase Cas3. (939 aa) |
| | cas1 | CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (277 aa) |
| | prf1 | Peptide chain release factor aRF1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (409 aa) |
| | eif5a | Translation initiation factor aIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (130 aa) |
| | BRM9_1925 | Histidine kinase/PAS domain-containing protein. (564 aa) |
| | trmG10 | RNA methylase. (344 aa) |
| | eif1a | Translation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (103 aa) |
| | BRM9_1939 | RNA-binding protein. (187 aa) |
| | top6B | DNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (526 aa) |
| | top6A | DNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (351 aa) |
| | BRM9_1952 | RNA-binding protein. (158 aa) |
| | BRM9_1953 | Small nuclear ribonucleoprotein; Belongs to the snRNP Sm proteins family. (100 aa) |
| | rpl37e | Ribosomal protein L37e Rpl37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (60 aa) |
| | BRM9_1971 | Staphylococcal nuclease domain-containing protein. (163 aa) |
| | mre11 | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (381 aa) |
| | mftR | TetR family transcriptional regulator. (202 aa) |
| | tbp | TATA-box binding protein Tbp; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (181 aa) |
| | fen | Flap endonuclease Fen; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. [...] (328 aa) |
| | BRM9_2001 | TrmB family transcriptional regulator. (270 aa) |
| | BRM9_2021 | Transcriptional regulator effector-binding domain protein. (154 aa) |
| | BRM9_2023 | Transcriptional regulator effector-binding domain protein. (153 aa) |
| | BRM9_2038 | Signal transduction histidine kinase. (402 aa) |
| | BRM9_2048 | TetR family transcriptional regulator. (186 aa) |
| | BRM9_2056 | TetR family transcriptional regulator. (222 aa) |
| | rps10 | Ribosomal protein S10P Rps10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | tuf | Translation elongation factor aEF-1 alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (413 aa) |
| | fusA | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (724 aa) |
| | rps7p | Ribosomal protein S7P Rps7p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (187 aa) |
| | rps12 | Ribosomal protein S12P Rps12p; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (141 aa) |
| | nusA | Transcription elongation factor NusA-like protein; Participates in transcription termination. Belongs to the NusA family. (143 aa) |
| | rpl30e | Ribosomal protein L30e Rpl30e; Belongs to the eukaryotic ribosomal protein eL30 family. (98 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A'' RpoA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (383 aa) |
| | rpoA1 | DNA-directed RNA polymerase subunit A' RpoA1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (871 aa) |
| | rpoB1 | DNA-directed RNA polymerase subunit B' RpoB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (603 aa) |
| | rpoB2 | DNA-directed RNA polymerase subunit B'' RpoB2; Belongs to the RNA polymerase beta chain family. (496 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H RpoH; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (78 aa) |
| | rnhB | Ribonuclease HII RnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (206 aa) |
| | BRM9_2115 | Endonuclease IV. (287 aa) |
| | xth | Exodeoxyribonuclease III Xth. (258 aa) |
| | BRM9_2127 | HTH and cupin domain-containing protein. (184 aa) |
| | BRM9_2136 | OB fold nucleic acid binding domain-containing protein. (133 aa) |
| | dnl1 | ATP-dependent DNA ligase DnlI; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (557 aa) |
| | BRM9_2138 | Histidine kinase/response regulator hybrid protein. (472 aa) |
| | BRM9_2152 | TetR family transcriptional regulator. (234 aa) |
| | BRM9_2159 | TetR family transcriptional regulator. (219 aa) |
| | BRM9_2196 | PadR-like family transcriptional regulator. (116 aa) |
| | BRM9_2220 | PadR-like family transcriptional regulator. (173 aa) |
| | polB3 | DNA polymerase family B PolB3. (590 aa) |
| | polD1 | DNA polymerase small subunit DP1 PolD1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (487 aa) |
| | ogg | 8-oxoguanine DNA glycosylase Ogg. (324 aa) |
| | BRM9_2357 | Rhodanese domain-containing protein. (110 aa) |
| | BRM9_2356 | Transposase. (322 aa) |
| | BRM9_2345 | Transposase. (350 aa) |
| | BRM9_2334 | Rhodanese domain-containing protein. (121 aa) |
| | BRM9_2332 | ATP-dependent DNA helicase. (582 aa) |
| | BRM9_2313 | HTH domain-containing protein. (71 aa) |
| | ileS | isoleucyl-tRNA synthetase IleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1048 aa) |
| | radA | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (311 aa) |
| | BRM9_2296 | Replication factor A. (791 aa) |
| | BRM9_2289 | Methanogenesis marker protein 11. (310 aa) |
| | ksgA | Dimethyladenosine transferase KsgA; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (279 aa) |
| | pus10 | Pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (406 aa) |
| | srp54 | Signal recognition particle SRP54 protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (442 aa) |
| | csl4 | Exosome complex RNA-binding protein Csl4; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (189 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L RpoL. (110 aa) |
| | tfs | Transcription factor S Tfs; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (104 aa) |
| | pcn | DNA polymerase sliding clamp subunit PCNA family Pcn; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (244 aa) |
| | rpl44e | Ribosomal protein L44e Rpl44e; Binds to the 23S rRNA. (93 aa) |
| | eif2a | Translation initiation factor aIF-2 alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (259 aa) |
| | nop10 | H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (56 aa) |
| | hypF | Hydrogenase maturation factor HypF. (772 aa) |
| | BRM9_2232 | HxlR family transcriptional regulator. (111 aa) |
| | cdc6-1 | Cdc6 family replication initiation protein Cdc6-1; Involved in regulation of DNA replication. (382 aa) |
| | BRM9_0004 | Hef nuclease. (794 aa) |
| | recJ1 | ssDNA exonuclease RecJ1. (451 aa) |
| | BRM9_0018 | Type II restriction endonuclease. (271 aa) |
| | BRM9_0027 | TetR family transcriptional regulator. (182 aa) |
| | thrS | threonyl-tRNA synthetase ThrS; Belongs to the class-II aminoacyl-tRNA synthetase family. (611 aa) |
| | BRM9_0037 | Radical SAM domain-containing protein. (373 aa) |
| | BRM9_0043 | TetR family transcriptional regulator. (178 aa) |
| | BRM9_0056 | TetR family transcriptional regulator. (208 aa) |
| | albA | DNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (93 aa) |
| | BRM9_0074 | PadR-like family transcriptional regulator. (169 aa) |
| | sepS | O-phosphoseryl-tRNA(Cys) synthetase SepS; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys). (552 aa) |
