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mrtB mrtB sucC sucC mtrA3 mtrA3 BRM9_1841 BRM9_1841 mch mch mtrA2 mtrA2 hdrA1 hdrA1 hdrB3 hdrB3 hdrC2 hdrC2 hdrB2 hdrB2 mcrB mcrB mcrD mcrD mcrC mcrC mcrG mcrG mcrA mcrA sucD sucD mdh mdh mer mer cbiX cbiX BRM9_0786 BRM9_0786 cdhB cdhB BRM9_0830 BRM9_0830 mvhA2 mvhA2 mtrH mtrH mtd mtd BRM9_0099 BRM9_0099 fwdG fwdG fwdD fwdD fwdB fwdB fwdC fwdC mtrE mtrE mtrD mtrD mtrC mtrC mtrB mtrB mtrG mtrG mtrA1 mtrA1 mtrF mtrF cbiA1 cbiA1 acs acs BRM9_0487 BRM9_0487 hdrB1 hdrB1 hdrC1 hdrC1 mvhA1 mvhA1 sdhB sdhB ehbL ehbL ehbF ehbF hdrA2 hdrA2 cbiX-2 cbiX-2 frhA frhA mrtA mrtA ftr2 ftr2 mrtG mrtG mrtD mrtD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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mrtBMethyl-coenzyme M reductase II beta subunit MrtB. (443 aa)
sucCsuccinyl-CoA synthetase beta subunit SucC; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (368 aa)
mtrA3Tetrahydromethanopterin S-methyltransferase subunit A MtrA3; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (181 aa)
BRM9_1841Hypothetical protein. (233 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase Mch; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (320 aa)
mtrA2Tetrahydromethanopterin S-methyltransferase subunit A MtrA2; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (204 aa)
hdrA1CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (794 aa)
hdrB3CoB--CoM heterodisulfide reductase subunit B HdrB3. (326 aa)
hdrC2CoB--CoM heterodisulfide reductase subunit C HdrC2. (195 aa)
hdrB2CoB--CoM heterodisulfide reductase subunit B HdrB2. (238 aa)
mcrBMethyl-coenzyme M reductase beta subunit McrB. (443 aa)
mcrDMethyl-coenzyme M reductase D subunit McrD. (144 aa)
mcrCMethyl-coenzyme M reductase C subunit McrC. (198 aa)
mcrGMethyl-coenzyme M reductase gamma subunit McrG. (249 aa)
mcrAMethyl-coenzyme M reductase alpha subunit McrA; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa)
sucDsuccinate-CoA ligase alpha subunit SucD; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (286 aa)
mdhMalate dehydrogenase Mdh; Belongs to the LDH/MDH superfamily. (323 aa)
mer5,10-methylenetetrahydromethanopterin reductase Mer; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa)
cbiXSirohydrochlorin cobaltochelatase CbiX; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (141 aa)
BRM9_0786Citrate synthase. (289 aa)
cdhBCO dehydrogenase/acetyl-CoA synthase epsilon subunit CdhB; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family. (172 aa)
BRM9_08302-methylcitrate synthase/citrate synthase II PrpC/CitZ. (287 aa)
mvhA2Methyl viologen-reducing hydrogenase alpha subunit MvhA2; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (472 aa)
mtrHTetrahydromethanopterin S-methyltransferase subunit H MtrH. (317 aa)
mtdF420-dependent methylenetetrahydromethanopterin dehydrogenase Mtd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa)
BRM9_0099Methanogenesis marker protein 13. (364 aa)
fwdGFormylmethanofuran dehydrogenase subunit G FwdG. (76 aa)
fwdDFormylmethanofuran dehydrogenase subunit D FwdD. (176 aa)
fwdBFormylmethanofuran dehydrogenase subunit B FwdB. (451 aa)
fwdCFormylmethanofuran dehydrogenase subunit C FwdC. (269 aa)
mtrETetrahydromethanopterin S-methyltransferase subunit E MtrE; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (295 aa)
mtrDTetrahydromethanopterin S-methyltransferase subunit D MtrD; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (241 aa)
mtrCTetrahydromethanopterin S-methyltransferase subunit C MtrC; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (270 aa)
mtrBTetrahydromethanopterin S-methyltransferase subunit B MtrB; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (100 aa)
mtrGTetrahydromethanopterin S-methyltransferase subunit G MtrG; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (84 aa)
mtrA1Tetrahydromethanopterin S-methyltransferase subunit A MtrA1; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (239 aa)
mtrFTetrahydromethanopterin S-methyltransferase subunit F MtrF; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (69 aa)
cbiA1Cobyrinic acid a,c-diamide synthase CbiA1; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (450 aa)
acsADP-dependent acetyl-CoA synthetase Acs. (714 aa)
BRM9_0487Metallophosphoesterase. (222 aa)
hdrB1CoB--CoM heterodisulfide reductase subunit B HdrB1. (299 aa)
hdrC1CoB--CoM heterodisulfide reductase subunit C HdrC1. (304 aa)
mvhA1Methyl viologen-reducing hydrogenase alpha subunit MvhA1; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (482 aa)
sdhBSuccinate dehydrogenase/fumarate reductase iron-sulfur protein SdhB. (501 aa)
ehbLEnergy-converting hydrogenase B subunit L EhbL. (162 aa)
ehbFEnergy-converting hydrogenase B subunit F EhbF. (501 aa)
hdrA2CoB--CoM heterodisulfide reductase subunit A HdrA2; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (658 aa)
cbiX-2Cobalamin biosynthesis protein CbiX; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (152 aa)
frhACoenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (405 aa)
mrtAMethyl-coenzyme M reductase II alpha subunit MrtA; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa)
ftr2Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr2; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa)
mrtGMethyl-coenzyme M reductase II gamma subunit MrtG. (266 aa)
mrtDMethyl-coenzyme M reductase II D subunit MrtD. (162 aa)
Your Current Organism:
Methanobacterium formicicum
NCBI taxonomy Id: 2162
Other names: ATCC 33274, JCM 10132, M. formicicum, Methanobacterium sp. BRM9, NBRC 100475, OCM 55, strain MF
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