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| | aksA | Homocitrate synthase AksA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | acsA1 | acetyl-CoA synthetase AcsA1. (635 aa) |
| | mtd | F420-dependent methylenetetrahydromethanopterin dehydrogenase Mtd; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa) |
| | fae-hps | Bifunctional formaldehyde-activating enzyme/3- hexulose-6-phosphate synthase Fae/Hps; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (406 aa) |
| | fwdH | Formylmethanofuran dehydrogenase subunit H FwdH. (154 aa) |
| | hxlB1 | 3-hexulose-6-phosphate isomerase HxlB1. (201 aa) |
| | fdhB | Formate dehydrogenase beta subunit FdhB; Catalyzes the oxidation of formate; Belongs to the FrhB family. (399 aa) |
| | fdhA | Formate dehydrogenase alpha subunit FdhA; Catalyzes the oxidation of formate. (684 aa) |
| | fwdF1 | Formylmethanofuran dehydrogenase subunit F FwdF1. (352 aa) |
| | fwdG | Formylmethanofuran dehydrogenase subunit G FwdG. (76 aa) |
| | fwdD | Formylmethanofuran dehydrogenase subunit D FwdD. (176 aa) |
| | fwdB | Formylmethanofuran dehydrogenase subunit B FwdB. (451 aa) |
| | fwdA | Formylmethanofuran dehydrogenase subunit A FwdA. (569 aa) |
| | fwdC | Formylmethanofuran dehydrogenase subunit C FwdC. (269 aa) |
| | fwdE1 | Formylmethanofuran dehydrogenase subunit E FwdE1. (189 aa) |
| | fwdE2 | Formylmethanofuran dehydrogenase subunit E FwdE2. (190 aa) |
| | fwdF2 | Formylmethanofuran dehydrogenase subunit FwdF2. (331 aa) |
| | ehbQ | Energy-converting hydrogenase B subunit Q EhbQ. (218 aa) |
| | BRM9_0333 | Nitroreductase family protein. (276 aa) |
| | BRM9_0334 | Nitroreductase family protein. (304 aa) |
| | comE | Sulfopyruvate decarboxylase subunit beta ComE. (183 aa) |
| | comD | Sulfopyruvate decarboxylase subunit alpha ComD. (163 aa) |
| | comC | L-sulfolactate dehydrogenase ComC. (344 aa) |
| | eno1 | Phosphopyruvate hydratase Eno1; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa) |
| | BRM9_0436 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (63 aa) |
| | hdrB1 | CoB--CoM heterodisulfide reductase subunit B HdrB1. (299 aa) |
| | hdrC1 | CoB--CoM heterodisulfide reductase subunit C HdrC1. (304 aa) |
| | BRM9_0525 | PadR-like family transcriptional regulator. (181 aa) |
| | mvhG1 | Methyl viologen-reducing hydrogenase gamma subunit MvhG1. (303 aa) |
| | mvhA1 | Methyl viologen-reducing hydrogenase alpha subunit MvhA1; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (482 aa) |
| | BRM9_0573 | Formylmethanofuran dehydrogenase subunit C. (310 aa) |
| | hxlB2 | 3-hexulose-6-phosphate isomerase HxlB2. (193 aa) |
| | fbp | Fructose 1,6-bisphosphatase Fbp; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (365 aa) |
| | aksF | Isohomocitrate dehydrogenase AksF. (339 aa) |
| | mdh | Malate dehydrogenase Mdh; Belongs to the LDH/MDH superfamily. (323 aa) |
| | BRM9_0648 | Glutamine amidotransferase. (305 aa) |
| | gltB1 | Glutamate synthase beta subunit GltB1. (230 aa) |
| | frhB2 | Coenzyme F420 hydrogenase beta subunit FrhB2. (366 aa) |
| | gltA1 | Glutamate synthase alpha subunit GltA1; Belongs to the glutamate synthase family. (499 aa) |
| | BRM9_0691 | Aminotransferase class V family. (381 aa) |
| | acsA2 | acetyl-CoA synthetase AcsA2. (620 aa) |
| | BRM9_0736 | Zinc finger CDGSH-type domain-containing protein. (241 aa) |
| | mer | 5,10-methylenetetrahydromethanopterin reductase Mer; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (321 aa) |
| | porC | Pyruvate ferredoxin oxidoreductase gamma subunit PorC. (174 aa) |
| | porD | Pyruvate ferredoxin oxidoreductase delta subunit PorD. (80 aa) |
| | porA | Pyruvate ferredoxin oxidoreductase alpha subunit PorA. (382 aa) |
| | porB | Pyruvate ferredoxin oxidoreductase beta subunit PorB. (287 aa) |
| | porE | Pyruvate ferredoxin oxidoreductase-associated PorE. (166 aa) |
| | porF | Pyruvate ferredoxin oxidoreductase-associated PorF. (142 aa) |
| | BRM9_0795 | 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (156 aa) |
| | cdhE | CO dehydrogenase/acetyl-CoA synthase gamma subunit CdhE; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (463 aa) |
| | cdhD | CO dehydrogenase/acetyl-CoA synthase delta subunit CdhD; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (387 aa) |
| | cdhC | CO dehydrogenase/acetyl-CoA synthase beta subunit CdhC; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (466 aa) |
| | cdhB | CO dehydrogenase/acetyl-CoA synthase epsilon subunit CdhB; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family. (172 aa) |
| | cdhA | CO dehydrogenase/acetyl-CoA synthase alpha subunit CdhA; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (787 aa) |
| | BRM9_0808 | Amino acid kinase family protein. (214 aa) |
| | serA | Phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | atwA1 | Methyl-coenzyme M reductase component A2 AtwA1. (534 aa) |
| | BRM9_0870 | PadR-like family transcriptional regulator. (182 aa) |
| | mfnA | L-tyrosine decarboxylase MfnA; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (383 aa) |
| | ppsA1 | Phosphoenolpyruvate synthase PpsA1; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (764 aa) |
| | mvhA2 | Methyl viologen-reducing hydrogenase alpha subunit MvhA2; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (472 aa) |
| | mvhG2 | Methyl viologen-reducing hydrogenase gamma subunit MvhG2. (309 aa) |
| | mvhD | Methyl viologen-reducing hydrogenase delta subunit MvhD. (148 aa) |
| | fae | Formaldehyde-activating enzyme Fae. (163 aa) |
| | mtrH | Tetrahydromethanopterin S-methyltransferase subunit H MtrH. (317 aa) |
| | mtrG | Tetrahydromethanopterin S-methyltransferase subunit G MtrG; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (84 aa) |
| | mtrF | Tetrahydromethanopterin S-methyltransferase subunit F MtrF; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (69 aa) |
| | mtrA1 | Tetrahydromethanopterin S-methyltransferase subunit A MtrA1; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (239 aa) |
| | mtrB | Tetrahydromethanopterin S-methyltransferase subunit B MtrB; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (100 aa) |
| | mtrC | Tetrahydromethanopterin S-methyltransferase subunit C MtrC; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (270 aa) |
| | mtrD | Tetrahydromethanopterin S-methyltransferase subunit D MtrD; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (241 aa) |
| | mtrE | Tetrahydromethanopterin S-methyltransferase subunit E MtrE; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (295 aa) |
| | mcrA | Methyl-coenzyme M reductase alpha subunit McrA; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa) |
| | mcrG | Methyl-coenzyme M reductase gamma subunit McrG. (249 aa) |
| | mcrC | Methyl-coenzyme M reductase C subunit McrC. (198 aa) |
| | mcrD | Methyl-coenzyme M reductase D subunit McrD. (144 aa) |
| | mcrB | Methyl-coenzyme M reductase beta subunit McrB. (443 aa) |
| | comB | 2-phosphosulfolactate phosphatase ComB. (222 aa) |
| | gltA2 | Glutamate synthase alpha subunit GltA2; Belongs to the glutamate synthase family. (620 aa) |
| | gltB2 | Glutamate synthase beta subunit GltB2. (211 aa) |
| | cofG | FO synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (354 aa) |
| | BRM9_1050 | Phosphoenolpyruvate synthase/pyruvate phosphate dikinase. (898 aa) |
| | nikR1 | Nickel responsive transcriptional regulator NikR1. (130 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (223 aa) |
| | atwA2 | Methyl-coenzyme M reductase component A2 AtwA2. (577 aa) |
| | mfnB | Hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (237 aa) |
| | eno2 | Phosphopyruvate hydratase Eno2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (413 aa) |
| | cofH1 | FO synthase subunit 2 CofH1; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (349 aa) |
| | acsA3 | acetyl-CoA synthetase AcsA3. (634 aa) |
| | aroA-2 | Phospho-2-dehydro-3-deoxyheptonate aldolase/fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | ehaP | Energy-converting hydrogenase A subunit P EhaP. (347 aa) |
| | ehaQ | Energy-converting hydrogenase A subunit Q EhaQ. (456 aa) |
| | ftr | Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr. (305 aa) |
| | hdrC2 | CoB--CoM heterodisulfide reductase subunit C HdrC2. (195 aa) |
| | hdrB3 | CoB--CoM heterodisulfide reductase subunit B HdrB3. (326 aa) |
| | hdrA1 | CoB--CoM heterodisulfide reductase subunit A HdrA1; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (794 aa) |
| | apgM1 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApgM1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (423 aa) |
| | cofH2 | FO synthase subunit 2 CofH2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (371 aa) |
| | aksE | Homoaconitase small subunit AksE; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD family. LeuD [...] (163 aa) |
| | BRM9_1504 | H4MPT-linked C1 transfer pathway protein. (346 aa) |
| | BRM9_1505 | ATP-grasp domain-containing protein. (337 aa) |
| | ppsA2 | Phosphoenolpyruvate synthase PpsA2. (411 aa) |
| | nikR2 | Nickel responsive transcriptional regulator NikR2; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (131 aa) |
| | gltA3 | Glutamate synthase alpha subunit GltA3; Belongs to the glutamate synthase family. (501 aa) |
| | cbiO2 | Cobalt ABC transporter ATP-binding protein CbiO2. (604 aa) |
| | mtrA2 | Tetrahydromethanopterin S-methyltransferase subunit A MtrA2; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (204 aa) |
| | mch | Methenyltetrahydromethanopterin cyclohydrolase Mch; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (320 aa) |
| | nikR3 | Nickel responsive transcriptional regulator NikR3; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (134 aa) |
| | hycI | Hydrogenase maturation protease HycI. (134 aa) |
| | comA | Phosphosulfolactate synthase ComA. (258 aa) |
| | apgM2 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase ApgM2; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (415 aa) |
| | BRM9_1874 | Demethylmenaquinone methyltransferase. (222 aa) |
| | serB | Phosphoserine phosphatase SerB. (496 aa) |
| | aksD | Homoaconitase large subunit AksD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa) |
| | trpY | Tryptophan-binding regulator TrpY. (167 aa) |
| | mtrA3 | Tetrahydromethanopterin S-methyltransferase subunit A MtrA3; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (181 aa) |
| | cofE | F420-0:gamma-glutamyl ligase CofE; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (256 aa) |
| | cofD | LPPG:FO 2-phospho-L-lactate transferase CofD; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (301 aa) |
| | atwA3 | Methyl-coenzyme M reductase component A2 AtwA3. (531 aa) |
| | acsA4 | acetyl-CoA synthetase AcsA4. (556 aa) |
| | mrtB | Methyl-coenzyme M reductase II beta subunit MrtB. (443 aa) |
| | mrtD | Methyl-coenzyme M reductase II D subunit MrtD. (162 aa) |
| | mrtG | Methyl-coenzyme M reductase II gamma subunit MrtG. (266 aa) |
| | mrtA | Methyl-coenzyme M reductase II alpha subunit MrtA; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (550 aa) |
| | ftr2 | Formylmethanofuran-tetrahydromethanopterin formyltransferase Ftr2; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa) |
| | BRM9_2220 | PadR-like family transcriptional regulator. (173 aa) |
| | frhB | Coenzyme F420 hydrogenase beta subunit FrhB. (294 aa) |
| | frhG | Coenzyme F420 hydrogenase gamma subunit FrhG. (264 aa) |
| | frhD | Coenzyme F420 hydrogenase delta subunit FrhD. (156 aa) |
| | frhA | Coenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (405 aa) |
| | hdrA2 | CoB--CoM heterodisulfide reductase subunit A HdrA2; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (658 aa) |
| | glyA | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (422 aa) |
| | fwdE3 | Formylmethanofuran dehydrogenase subunit E FwdE3. (201 aa) |
| | fwdE4 | Formylmethanofuran dehydrogenase subunit E FwdE4. (205 aa) |
